在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DPYS Antibody

  • 中文名稱:
    DPYS兔多克隆抗體
  • 貨號:
    CSB-PA007169ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: DPYS antibody at 1.34μg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 57 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA007169ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007169ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DPYS Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DPYS
  • 別名:
    DHP antibody; DHPase antibody; Dihydropyrimidinase antibody; Dihydropyrimidine amidohydrolase antibody; Dpys antibody; DPYS_HUMAN antibody; Hydantoinase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Dihydropyrimidinase protein (250-519AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
  • 基因功能參考文獻:
    1. 4 newly identified DHP deficient patients presented with strongly elevated levels of 5,6-dihydrouracil and 5,6-dihydrothymine in urine and a highly variable clinical presentation, ranging from asymptomatic to infantile spasm and reduced white matter and brain atrophy. Analysis of the DHP gene (DPYS) showed the presence of 8 variants including 4 novel/rare missense variants and one novel deletion. PMID: 29054612
    2. Two unrelated pediatric DPYS deficiency cases are being described as compound heterozygotes for a novel intronic mutation c.1443+5G>A in intron 8 and a previously described missense mutation c.1001A>G (p.Q334R) in exon 6. PMID: 26771602
    3. Stepwise Cox regression modelling suggested that the methylation of genes HSPB1, CCND2 and DPYS contributed objective prognostic information to Gleason score and PSA with respect to prostate cancer-related death. PMID: 25193387
    4. The p.S379R and p.L7V mutations were likely to cause structural destabilization and protein misfolding. Four mutations were identified in multiple unrelated DHP patients, indicating that DHP deficiency may be more common than anticipated. PMID: 20362666
    5. Results indicate that missense and nonsense variants in DPYS are infrequent, however, the development of serious primarily gastrointestinal toxicity could be influenced by non-coding DPYS sequence variants c.-1T>C and IVS1-58T>C. PMID: 19649633
    6. clinical, biochemical & genetic findings of two newly identified patients with a complete DHP deficiency; both patients were compound heterozygous for the missense mutation 1078T>C (W360R) in exon 6 and a novel missense mutation 1235G>T (R412M) in exon 7 PMID: 17383919
    7. data presented in this study offers evidence for the possible genetic regulation of the DPYS gene and its possible influence on uracil catabolic pathway PMID: 18075467

    顯示更多

    收起更多

  • 相關疾病:
    Dihydropyrimidinase deficiency (DPYSD)
  • 蛋白家族:
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 組織特異性:
    Liver and kidney.
  • 數據庫鏈接:

    HGNC: 3013

    OMIM: 222748

    KEGG: hsa:1807

    STRING: 9606.ENSP00000276651

    UniGene: Hs.443161



主站蜘蛛池模板: 亚洲精品字幕| 欧美老肥熟妇多毛xxxxx| 伊人中文字幕无码专区| 无码一区二区三区av在线播放 | 国产成人精品优优av| 国产xxxx做受性欧美88| 在线v片免费观看视频| 中国美女牲交视频| 国产精品爽爽久久久久久| 国产精品国产三级在线专区| 亚洲电影天堂av2017| 日本熟妇厨房xxxxx乱| 国产午夜福利精品久久2021| 亚在线观看免费视频入口| 久久久欧美精品激情| 国产女人叫床高潮大片| 又色又爽又黄18禁美女裸身无遮挡| 亚洲一区av无码少妇电影| 成人一区二区免费中文字幕视频| 好吊射视频988gaocom| 国产一区二区三区内射高清| 麻豆一区二区三区蜜桃免费| 欧美黑人性暴力猛交喷水黑人巨大| 最近高清中文在线字幕在线观看1| a三级三级成人网站在线视频| 少妇性饥渴无码a区免费| 2017亚洲天堂最新地址| 午夜性色吃奶添下面69影院 | 国产无套粉嫩白浆在线观看| 国产av一区二区三区| 8天堂资源在线| 亚洲龙腾成小说人网| 男人女人做爽爽18禁网站| 高中生自慰www网站| 国产激情大臿免费视频| 92精品成人国产在线观看| 国产网红无码精品视频| 亚洲国产综合无码一区| 18勿入网站免费永久| 久久香蕉国产线看观看猫咪av| 蜜桃网站入口在线进入|