在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DPYS Antibody

  • 中文名稱:
    DPYS兔多克隆抗體
  • 貨號:
    CSB-PA007169GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DPYS
  • 別名:
    DHP antibody; DHPase antibody; Dihydropyrimidinase antibody; Dihydropyrimidine amidohydrolase antibody; Dpys antibody; DPYS_HUMAN antibody; Hydantoinase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DPYS
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
  • 基因功能參考文獻:
    1. 4 newly identified DHP deficient patients presented with strongly elevated levels of 5,6-dihydrouracil and 5,6-dihydrothymine in urine and a highly variable clinical presentation, ranging from asymptomatic to infantile spasm and reduced white matter and brain atrophy. Analysis of the DHP gene (DPYS) showed the presence of 8 variants including 4 novel/rare missense variants and one novel deletion. PMID: 29054612
    2. Two unrelated pediatric DPYS deficiency cases are being described as compound heterozygotes for a novel intronic mutation c.1443+5G>A in intron 8 and a previously described missense mutation c.1001A>G (p.Q334R) in exon 6. PMID: 26771602
    3. Stepwise Cox regression modelling suggested that the methylation of genes HSPB1, CCND2 and DPYS contributed objective prognostic information to Gleason score and PSA with respect to prostate cancer-related death. PMID: 25193387
    4. The p.S379R and p.L7V mutations were likely to cause structural destabilization and protein misfolding. Four mutations were identified in multiple unrelated DHP patients, indicating that DHP deficiency may be more common than anticipated. PMID: 20362666
    5. Results indicate that missense and nonsense variants in DPYS are infrequent, however, the development of serious primarily gastrointestinal toxicity could be influenced by non-coding DPYS sequence variants c.-1T>C and IVS1-58T>C. PMID: 19649633
    6. clinical, biochemical & genetic findings of two newly identified patients with a complete DHP deficiency; both patients were compound heterozygous for the missense mutation 1078T>C (W360R) in exon 6 and a novel missense mutation 1235G>T (R412M) in exon 7 PMID: 17383919
    7. data presented in this study offers evidence for the possible genetic regulation of the DPYS gene and its possible influence on uracil catabolic pathway PMID: 18075467

    顯示更多

    收起更多

  • 相關疾病:
    Dihydropyrimidinase deficiency (DPYSD)
  • 蛋白家族:
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 組織特異性:
    Liver and kidney.
  • 數據庫鏈接:

    HGNC: 3013

    OMIM: 222748

    KEGG: hsa:1807

    STRING: 9606.ENSP00000276651

    UniGene: Hs.443161



主站蜘蛛池模板: 国产精品久久久久9999高清| 在线观看国产精品av| 九九综合va免费看| 人妻熟女一区二区三区app下载 | 无码人妻丰满熟妇奶水区码| 久久精品国产精品亚洲| 国产激情大臿免费视频| 久久久久久无码精品人妻a片软件| 国产精品香蕉视频在线| 亚洲国产精品久久久久久久| 综合无码一区二区三区| 久久精品农村毛片| av天堂中av世界中文在线播放| 国产成人综合日韩精品无码不卡| 极品少妇xxxx精品少妇偷拍| 国产乱子伦精品视频| 成年奭片免费观看视频天天看| 国产偷国产偷亚洲清高网站| 亚洲国产精品va在线看黑人| 伊人色综合久久天天五月婷| 人妻系列无码专区av在线| 999国内精品永久免费观看| 色噜噜狠狠狠综合曰曰曰| 日本十八禁视频无遮挡| 华人在线亚洲欧美精品| 无码人妻日韩一区日韩二区| 午夜不卡av免费| 好爽毛片一区二区三区四| 12裸体自慰免费观看网站| 玩两个丰满老熟女久久网| 免费人成视频x8x8| 亚洲国产精品久久久久久| 久久毛片免费看一区二区三区| 欧美中日韩免费观看网站| 日本最新免费二区三区| 七七久久成人影院网站| 亚洲aⅴ综合av国产八av| 国产欧美在线观看不卡| 日韩av高清在线观看| 无码免费无线观看在线视| 久久久日韩精品一区二区三区|