在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DPYS Antibody

  • 中文名稱:
    DPYS兔多克隆抗體
  • 貨號:
    CSB-PA007169GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DPYS
  • 別名:
    DHP antibody; DHPase antibody; Dihydropyrimidinase antibody; Dihydropyrimidine amidohydrolase antibody; Dpys antibody; DPYS_HUMAN antibody; Hydantoinase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DPYS
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
  • 基因功能參考文獻:
    1. 4 newly identified DHP deficient patients presented with strongly elevated levels of 5,6-dihydrouracil and 5,6-dihydrothymine in urine and a highly variable clinical presentation, ranging from asymptomatic to infantile spasm and reduced white matter and brain atrophy. Analysis of the DHP gene (DPYS) showed the presence of 8 variants including 4 novel/rare missense variants and one novel deletion. PMID: 29054612
    2. Two unrelated pediatric DPYS deficiency cases are being described as compound heterozygotes for a novel intronic mutation c.1443+5G>A in intron 8 and a previously described missense mutation c.1001A>G (p.Q334R) in exon 6. PMID: 26771602
    3. Stepwise Cox regression modelling suggested that the methylation of genes HSPB1, CCND2 and DPYS contributed objective prognostic information to Gleason score and PSA with respect to prostate cancer-related death. PMID: 25193387
    4. The p.S379R and p.L7V mutations were likely to cause structural destabilization and protein misfolding. Four mutations were identified in multiple unrelated DHP patients, indicating that DHP deficiency may be more common than anticipated. PMID: 20362666
    5. Results indicate that missense and nonsense variants in DPYS are infrequent, however, the development of serious primarily gastrointestinal toxicity could be influenced by non-coding DPYS sequence variants c.-1T>C and IVS1-58T>C. PMID: 19649633
    6. clinical, biochemical & genetic findings of two newly identified patients with a complete DHP deficiency; both patients were compound heterozygous for the missense mutation 1078T>C (W360R) in exon 6 and a novel missense mutation 1235G>T (R412M) in exon 7 PMID: 17383919
    7. data presented in this study offers evidence for the possible genetic regulation of the DPYS gene and its possible influence on uracil catabolic pathway PMID: 18075467

    顯示更多

    收起更多

  • 相關疾病:
    Dihydropyrimidinase deficiency (DPYSD)
  • 蛋白家族:
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 組織特異性:
    Liver and kidney.
  • 數據庫鏈接:

    HGNC: 3013

    OMIM: 222748

    KEGG: hsa:1807

    STRING: 9606.ENSP00000276651

    UniGene: Hs.443161



主站蜘蛛池模板: 午夜时刻免费入口| 亚洲色www永久网站| 少妇荡乳情欲办公室456视频| 国产l精品国产亚洲区久久| 国精产品一区一区三区有限在线| 男女车车的车车网站w98免费| 女人裸露免费视频无遮挡网站 | 久久国语露脸国产精品电影| 成av人电影在线观看| 久久精品国产99久久6动漫| 少妇mm被擦出白浆液视频| 中文字幕亚洲综合久久蜜桃| 夜夜添无码一区二区三区| 少妇无码太爽了不卡视频在线看 | 2020精品国产视| 人妻无码av中文系列久| 午夜理论片yy6080私人影院| 亚洲精品久久7777777| 少妇夜夜春夜夜爽试看视频| 亚洲精品无码鲁网中文电影| 亚洲中文字幕无码久久2017| 日本乱偷互换人妻中文字幕 | 成人综合网亚洲伊人| 永久免费观看国产裸体美女| 玩弄人妻少妇精品视频| 精品麻豆国产色欲色欲色欲www| 99久久精品国产一区二区| 精品国偷自产在线视频| 成人国产精品一区二区网站公司| 亚欧无线一线二线三线区别| 久久国产免费福利永久| 99精品人妻少妇一区二区| 97se亚洲国产综合在线| 国产天堂久久天堂av色综合| 蜜臀精品国产高清在线观看| 久久视热这里只有精品| 少妇被爽到高潮喷水久久欧美精品| 久久人妻无码一区二区| 久久久精品2019免费观看| 国产精品系列无码专区| 国产女人被狂躁到高潮小说|