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  4. DOCK7 Antibody, HRP conjugated

DOCK7 Antibody, HRP conjugated

  • 中文名稱：
    DOCK7兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA836266LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DOCK7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DOCK7
  • 別名：
    DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dedicator of cytokinesis protein 7 protein (1440-1671AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3.
  • 基因功能參考文獻：
    1. these results suggest that the DOCK-ANGPTL3 SNPs and their haplotypes were associated with the angiographic severity to coronary artery atherosclerosis and the risk of coronary artery disease (CAD) and ischemic stroke in the Southern Chinese Han population. PMID: 29454388
    2. Possible inter-locus interactions among the DOCK7, PCSK9 and GALNT2 SNPs were also noted. PMID: 26493351
    3. Differences in lipid profiles between the Jing and Han populations might partially attribute to the DOCK7, PCSK9 and GALNT2 gene polymorphisms and their haplotypes determining different risk for the development of cardiovascular diseases. PMID: 26744084
    4. Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. PMID: 27018747
    5. These observations suggest that loss of DOCK7 function causes a syndromic form of epileptic encephalopathy by affecting multiple neuronal processes. PMID: 24814191
    6. Dock7 mediates serum- and HGF-induced glioblastoma cell invasion. PMID: 24518591
    7. DOCK7 functions as an essential and downstream regulator of RAGE-mediated cellular migration through the formation of dendritic pseudopodia. PMID: 23254359
    8. The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex. PMID: 23718289
    9. Dock7 functions as an intracellular substrate for ErbB2 to promote Schwann cell migration. PMID: 18426980

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  • 相關(guān)疾病：
    Epileptic encephalopathy, early infantile, 23 (EIEE23)
  • 亞細胞定位：
    Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.
  • 蛋白家族：
    DOCK family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19190

    OMIM: 615730

    KEGG: hsa:85440

    STRING: 9606.ENSP00000340742

    UniGene: Hs.744927



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