在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DNMT3L Antibody

DNMT3L Antibody

  • 中文名稱：
    DNMT3L兔多克隆抗體
  • 貨號：
    CSB-PA891717LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescent analysis of Hela cells using CSB-PA891717LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
      All lanes: DNMT3L antibody at 3.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 44 kDa
      Observed band size: 44 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DNMT3L Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DNMT3L
  • 別名：
    Cytosine 5 methyltransferase 3 like protein antibody; DNA (cytosine 5 ) methyltransferase 3 like antibody; DNA (cytosine-5)-methyltransferase 3-like antibody; DNA cytosine 5 methyltransferase 3 like protein antibody; DNA methyltransferase 3 like protein antibody; DNM3L_HUMAN antibody; Dnmt 3L antibody; Dnmt3l antibody; Human cytosine 5 methyltransferase 3 like protein antibody; MGC1090 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DNA (cytosine-5)-methyltransferase 3-like protein (1-234AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，DNMT3L Antibody (CSB-PA891717LA01HU)，的標記方式是Non-conjugated。對于DNMT3L Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA891717LB01HU DNMT3L Antibody, HRP conjugated ELISA
    FITC CSB-PA891717LC01HU DNMT3L Antibody, FITC conjugated
    Biotin CSB-PA891717LD01HU DNMT3L Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context. Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain. Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3. Plays a key role in embryonic stem cells and germ cells. In germ cells, required for the methylation of imprinted loci together with DNMT3A. In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization. Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation. While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes. Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes. Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression.
  • 基因功能參考文獻：
    1. DNMT3L overexpression is associated with Down syndrome. PMID: 26911678
    2. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility. PMID: 26647998
    3. DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history. PMID: 24859147
    4. crystal structures of DNMT3A-DNMT3L (autoinhibitory form) and DNMT3A-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively PMID: 25383530
    5. DNMT3L can address DNMT3A/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A/B PMID: 24952347
    6. CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element PMID: 24743422
    7. DNMT3L is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review) PMID: 22671959
    8. SNP rs2070565, as well as haplotypes AAA and GAA, may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans PMID: 22116073
    9. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis. PMID: 22401780
    10. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages. PMID: 21126912
    11. This study offers insights into the manner by which DNA methylation patterns are deposited and reveals a new level of interplay between members of the de novo DNMT family. PMID: 20838592
    12. Processive methylation is enhanced 3-fold in the presence of DNMT3L, an inactive homolog of DNMT3A, therefore providing a mechanism for the previously described DNMT3L activation of DNMT3A. PMID: 20630873
    13. We have identified loss of methylation at the DNMT3L promoter in ocular surface squamous neoplasia cases. PMID: 20670142
    14. DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma. PMID: 20460473
    15. DNMT3L exerts a major effect on the transcriptional regulation of a specific target gene, such as thymine DNA glycosylase PMID: 20428781
    16. CG dinucleotide recognized by the Dnmt3a and Dnmt3L complex are distinctive at retroelements and imprinted domains. PMID: 19921333
    17. DNMT3L stimulates de novo methylation by Dnmt3a. PMID: 12481029
    18. The carboxyl-terminal half of DNMT3L was found to be responsible for the stimulation of the DNA methylation activity of Dnmt3a and Dnmt3b. PMID: 15105426
    19. Regulates germ cell-specific gene expression and intracisternal A-particle suppression, which are critical for male germ cell proliferation and meiosis. PMID: 16211598
    20. Dnmt3L-Dnmt3b interactions play an important role in the regulation of DNA methylation during mammalian development. PMID: 16543361
    21. The acquisition of DNMT3L by a common ancestor of eutherians and marsupials might have been closely related to the evolution of imprinting. PMID: 16575165
    22. Data show that binding of DNMT3L to DNMT3A2 promotes reorganization of DNMT3A2 subunits and leads to formation of specific complexes with enhanced DNA methyltransferase activity and increased S-adenosyl-L-methionine binding. PMID: 16829525
    23. Crystallographic studies of human DNMT3L showed that the protein has a carboxy-terminal methyltransferase-like domain and an N-terminal cysteine-rich domain PMID: 17687327
    24. the carboxy-terminal domain of human Dnmt3L interacts with the catalytic domain of Dnmt3a, demonstrating that Dnmt3L has dual functions of binding the unmethylated histone tail and activating DNA methyltransferase PMID: 17713477
    25. Importance of DNA methylation profile at DNMT3L promoter not only as a promising biomarker for cervical cancer but also provides insight into the possible role of DNMT3L in cancer development. PMID: 17965599
    26. DNMT3L(R271Q) is impaired in its ability to stimulate de novo DNA methylation by DNMT3A. PMID: 19246518
    27. Overexpression of DNMT3L, which functions by regulating the activity of DNMT3A and DNMT3B, increased cellular proliferation and anchorage-independent growth. PMID: 19625766

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed at low levels in several tissues including testis, ovary, and thymus.
  • 數據庫鏈接：

    HGNC: 2980

    OMIM: 606588

    KEGG: hsa:29947

    STRING: 9606.ENSP00000270172

    UniGene: Hs.592165



主站蜘蛛池模板： 国产精品久久久久久av| 成人免费无码大片a毛片户外| 三级网站视频在在线播放| 成人免费毛片aaaaaa片| 婷婷五月深深久久精品 | 亚洲国产美国国产综合一区| 爆乳喷奶水无码正在播放| 三上悠亚久久精品| 国产sm主人调教女m视频| 成人精品动漫一区二区| 在线看午夜福利片国产| 两口子交换真实刺激高潮| 日本特黄特色特爽大片| 成在人线av无码免费高潮喷水| 久久www色情成人免费观看| 第九色区av天堂| 久久久久人妻精品一区三寸| 女学生14毛片视频片二毛| 国产色秀视频在线播放| 国产精品亚洲αv天堂无码| 日韩av无码成人无码免费| 欧美国产日韩亚洲中文| 国产成年无码久久久久毛片 | 免费人成又黄又爽的视频| 国产伦精品一区二区三区免.费| 黄a无码片内射无码视频| 国产人妻精品一区二区三区| 动漫人妻h无码中文字幕| 在线播放免费播放av片| 成年女人免费视频播放体验区| 日韩精品无码视频一区二区蜜桃| 免费无遮挡很爽很污很黄的网站| 国产午夜高潮熟女精品av软件 | 久久精品中文字幕一区二区三区| 国产精品人成在线播放新网站| 中国猛少妇色xxxxx| 国产女人被狂躁到高潮小说| 真人做人试看60分钟免费视频| 国产精品天干在线观看| 中文字幕高清免费日韩视频在线 | 污污污污污污污网站污|