在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DNMT3L Antibody

DNMT3L Antibody

  • 中文名稱：
    DNMT3L兔多克隆抗體
  • 貨號：
    CSB-PA007086GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DNMT3L
  • 別名：
    Cytosine 5 methyltransferase 3 like protein antibody; DNA (cytosine 5 ) methyltransferase 3 like antibody; DNA (cytosine-5)-methyltransferase 3-like antibody; DNA cytosine 5 methyltransferase 3 like protein antibody; DNA methyltransferase 3 like protein antibody; DNM3L_HUMAN antibody; Dnmt 3L antibody; Dnmt3l antibody; Human cytosine 5 methyltransferase 3 like protein antibody; MGC1090 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human DNMT3L
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context. Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain. Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3. Plays a key role in embryonic stem cells and germ cells. In germ cells, required for the methylation of imprinted loci together with DNMT3A. In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization. Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation. While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes. Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes. Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression.
  • 基因功能參考文獻：
    1. DNMT3L overexpression is associated with Down syndrome. PMID: 26911678
    2. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility. PMID: 26647998
    3. DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history. PMID: 24859147
    4. crystal structures of DNMT3A-DNMT3L (autoinhibitory form) and DNMT3A-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively PMID: 25383530
    5. DNMT3L can address DNMT3A/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A/B PMID: 24952347
    6. CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element PMID: 24743422
    7. DNMT3L is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review) PMID: 22671959
    8. SNP rs2070565, as well as haplotypes AAA and GAA, may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans PMID: 22116073
    9. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis. PMID: 22401780
    10. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages. PMID: 21126912
    11. This study offers insights into the manner by which DNA methylation patterns are deposited and reveals a new level of interplay between members of the de novo DNMT family. PMID: 20838592
    12. Processive methylation is enhanced 3-fold in the presence of DNMT3L, an inactive homolog of DNMT3A, therefore providing a mechanism for the previously described DNMT3L activation of DNMT3A. PMID: 20630873
    13. We have identified loss of methylation at the DNMT3L promoter in ocular surface squamous neoplasia cases. PMID: 20670142
    14. DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma. PMID: 20460473
    15. DNMT3L exerts a major effect on the transcriptional regulation of a specific target gene, such as thymine DNA glycosylase PMID: 20428781
    16. CG dinucleotide recognized by the Dnmt3a and Dnmt3L complex are distinctive at retroelements and imprinted domains. PMID: 19921333
    17. DNMT3L stimulates de novo methylation by Dnmt3a. PMID: 12481029
    18. The carboxyl-terminal half of DNMT3L was found to be responsible for the stimulation of the DNA methylation activity of Dnmt3a and Dnmt3b. PMID: 15105426
    19. Regulates germ cell-specific gene expression and intracisternal A-particle suppression, which are critical for male germ cell proliferation and meiosis. PMID: 16211598
    20. Dnmt3L-Dnmt3b interactions play an important role in the regulation of DNA methylation during mammalian development. PMID: 16543361
    21. The acquisition of DNMT3L by a common ancestor of eutherians and marsupials might have been closely related to the evolution of imprinting. PMID: 16575165
    22. Data show that binding of DNMT3L to DNMT3A2 promotes reorganization of DNMT3A2 subunits and leads to formation of specific complexes with enhanced DNA methyltransferase activity and increased S-adenosyl-L-methionine binding. PMID: 16829525
    23. Crystallographic studies of human DNMT3L showed that the protein has a carboxy-terminal methyltransferase-like domain and an N-terminal cysteine-rich domain PMID: 17687327
    24. the carboxy-terminal domain of human Dnmt3L interacts with the catalytic domain of Dnmt3a, demonstrating that Dnmt3L has dual functions of binding the unmethylated histone tail and activating DNA methyltransferase PMID: 17713477
    25. Importance of DNA methylation profile at DNMT3L promoter not only as a promising biomarker for cervical cancer but also provides insight into the possible role of DNMT3L in cancer development. PMID: 17965599
    26. DNMT3L(R271Q) is impaired in its ability to stimulate de novo DNA methylation by DNMT3A. PMID: 19246518
    27. Overexpression of DNMT3L, which functions by regulating the activity of DNMT3A and DNMT3B, increased cellular proliferation and anchorage-independent growth. PMID: 19625766

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed at low levels in several tissues including testis, ovary, and thymus.
  • 數據庫鏈接：

    HGNC: 2980

    OMIM: 606588

    KEGG: hsa:29947

    STRING: 9606.ENSP00000270172

    UniGene: Hs.592165



主站蜘蛛池模板： 男男女女爽爽爽免费视频| 亚洲最大的熟女水蜜桃av网站| 成人a片产无码免费视频在线观看| 欧美大片欧美激情性色a∨在线| 欧美写真视频在线观看| 国产麻豆剧传媒精品国产av| 国产欧美精品aaaaaa片| 狠狠久久噜噜熟女| 少妇被爽到高潮在线观看| 精品视频在线观自拍自拍| 内射爽无广熟女亚洲| 人妻无码久久精品| 人妻aⅴ中文字幕| 国产亚洲福利在线视频| 无码精品人妻一区二区三区av| 琪琪午夜伦埋影院77| 女人与拘做受全过程免费视频| 人妻夜夜爽天天爽三区麻豆av网站| 天堂а√中文最新版在线| 中国做爰国产精品视频| 欧美日韩亚洲国产欧美电影| 中文无码一区二区不卡αv| 欧美黑人粗大xxxxbbbb| 免费两性的视频网站| 亚洲人成网站在小说| 又粗又大内射免费视频小说| 无码人妻一区二区三区在线视频| 国产玉足脚交极品在线播放| 秋霞午夜鲁丝片午夜精品| 99久久人人爽亚洲精品美女| 亚洲日韩乱码一区二区三区四区 | 高h纯肉无码视频在线观看| 国产精品99久久免费| 日本19禁啪啪吃奶大尺度| 免费无码又爽又刺激软件下载直播| 99久久久国产精品无码免费| 天天综合亚洲色在线精品| 精品四虎国产在免费观看| 亚洲性夜色噜噜噜网站2258kk| 在线a视频网站| 亚洲国产成人久久综合人|