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  4. DNASE2 Antibody

DNASE2 Antibody

  • 中文名稱：
    DNASE2兔多克隆抗體
  • 貨號：
    CSB-PA007053LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, PC-3 whole cell lysate
      All lanes: DNASE2 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 40, 34 kDa
      Observed band size: 40 kDa
    • IHC image of CSB-PA007053LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DNASE2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DNASE2
  • 別名：
    Acid DNase antibody; Deoxyribonuclease 2 alpha antibody; Deoxyribonuclease 2 antibody; Deoxyribonuclease II alpha antibody; Deoxyribonuclease II antibody; Deoxyribonuclease II lysosomal antibody; Deoxyribonuclease-2-alpha antibody; Deoxyribonuclease2 antibody; DeoxyribonucleaseII antibody; DNASE 2 antibody; DNASE 2A antibody; DNase II alpha antibody; DNase II lysosomal antibody; DNASE2 antibody; DNASE2A antibody; DNaseII antibody; DNL 2 antibody; DNL antibody; DNL2 antibody; DNS2A_HUMAN antibody; Lysosomal DNase II antibody; R31240 2 antibody; R31240_2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Deoxyribonuclease-2-alpha protein (19-152AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，DNASE2 Antibody (CSB-PA007053LA01HU)，的標記方式是Non-conjugated。對于DNASE2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA007053LB01HU DNASE2 Antibody, HRP conjugated ELISA
    FITC CSB-PA007053LC01HU DNASE2 Antibody, FITC conjugated
    Biotin CSB-PA007053LD01HU DNASE2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
  • 基因功能參考文獻：
    1. Study identifies biallelic mutations in DNASE2, associated with a loss of DNase II endonuclease activity causing type I interferonopathy in three patients from two unrelated families. PMID: 29259162
    2. 15 nonsynonymous human DNase II SNPs were genotyped in three ethnic groups including 16 different populations using the PCR-restriction fragment length polymorphism technique. PMID: 24242851
    3. study demonstrated the relationship of genotypes/haplotypes with the in vivo DNase II and promoter activities; significant correlations between genotype in each rheumatoid arthritis (RA)-related SNP and enzymatic activity levels were found; alleles associated with RA exhibited a reduction in serum DNase II activity. PMID: 23019102
    4. upregulation of expression during myelomonocytic differentiation of HL-60 and THP-1 cells PMID: 12147225
    5. Sp1 and Sp3 are involved in up-regulation of this enzyme's transcriptoin during cell differentiation of hl-60 cells. PMID: 12694199
    6. the enzyme is a monomeric phospholipase D-family member with a pseudodimeric protein fold PMID: 17192590
    7. The association of SNPs in the 5'-regulatory region of the DNA degrading enzyme DNASE2 with Rheumatoid Arthritis implies a role for this enzyme in the pathogenesis of this autoimmune disease. PMID: 18812394

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  • 亞細胞定位：
    Lysosome.
  • 蛋白家族：
    DNase II family
  • 數據庫鏈接：

    HGNC: 2960

    OMIM: 126350

    KEGG: hsa:1777

    STRING: 9606.ENSP00000222219

    UniGene: Hs.118243



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