在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DNAJC10 Antibody

DNAJC10 Antibody

  • 中文名稱：
    DNAJC10兔多克隆抗體
  • 貨號：
    CSB-PA048817
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA048817(DNAJC10 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA048817(DNAJC10 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DNAJC10 antibody; ERDJ5 antibody; UNQ495/PRO1012DnaJ homolog subfamily C member 10 antibody; EC 1.8.4.- antibody; Endoplasmic reticulum DNA J domain-containing protein 5 antibody; ER-resident protein ERdj5 antibody; ERdj5 antibody; Macrothioredoxin antibody; MTHr antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human DNAJC10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
  • 基因功能參考文獻：
    1. Role of ERdj5 conformational dynamics in endoplasmic reticulum associated degradation PMID: 28479060
    2. ERdj5 is a member of the proteostasis network that regulates rod opsin biogenesis and supports a role for disulfide bond formation/reduction in rod opsin biogenesis and disease. PMID: 25055872
    3. ERdj5, by binding to Sel1L, triggers BiP-Cholera toxin interaction proximal to the Hrd1 complex; postulate this scenario enables the Hrd1-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP PMID: 23363602
    4. ERdj5 acts as the endoplasmic reticulum reductase, both preparing misfolded proteins for degradation and catalyzing the folding of proteins that form obligatory non-native disulfides. PMID: 23769672
    5. ERdj5 is a ubiquitous protein localized in the ER and is particularly abundant in secretory cells. Its transcription is induced during ER stress, suggesting potential roles for ERdj5 in protein folding and translocation across the ER membrane. PMID: 12411443
    6. JPDI may have roles in folding of some proteins in the ER, chaperoning by BiP and formation of proper disulfide bonds PMID: 12446677
    7. The organization of the functional motifs of hMTHr suggests that the protein might be a member of a molecular chaperone family. PMID: 14587667
    8. ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity. PMID: 18400946
    9. study found that an endoplasmic reticulum (ER) protein ERdj5 had a reductase activity, cleaved the disulfide bonds of misfolded proteins & accelerated ER-associated degradation through its physical and functional associations with EDEM & BiP PMID: 18653895
    10. ERdj5 decreases neuroblastoma cell survival by down-regulating the UPR, raising the possibility that this protein could be a target for anti-tumor approaches. PMID: 19122239

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 數據庫鏈接：

    HGNC: 24637

    OMIM: 607987

    KEGG: hsa:54431

    STRING: 9606.ENSP00000264065

    UniGene: Hs.516632



主站蜘蛛池模板： 久久不见久久见免费影院www| 久久免费午夜福利院| 国产午夜精品理论片| 欧美综合自拍亚洲综合图片区| 中文字幕人妻a片免费看| 久热这里在线精品| 亚洲国产成人无码电影| 青青草免费公开视频| 一本一本久久a久久精品综合| 日韩国产高清一区二区| 92午夜少妇极品福利无码电影| 亚洲中文久久精品无码1| 国产精品午夜无码av天美传媒| 精品黑人一区二区三区久久| 男人用嘴添女人私密视频| 亚洲欧美日韩国产综合点击进入| 欧美激性欧美激情在线| 四虎永久在线精品免费一区二区| 99久热在线精品996热是什么| 国产98在线 | 日韩| 国产做爰xxxⅹ久久久小说| 欧美日韩国产中文高清视频| 性一交一乱一乱一视频| 欧美成人在线视频| 国产三区在线成人av| 久热这里只有精品99在线观看| 国产熟睡乱子伦午夜视频麻豆| 人妻少妇精品视频二区| 四虎国产精品亚洲一区久久特色| 久久精品成人免费观看| 正在播放国产剧情亂倫| 欧美s码亚洲码精品m码| 日韩乱码人妻无码中文字幕视频 | 亚洲另类成人小说综合网 | 污污污污污污污网站污| 国产精品水嫩水嫩| 国产成人精品.视频| 青青草国产免费国产是公开| √天堂8资源中文在线| 日日摸日日添日日碰9学生露脸| 午夜福利电影网站鲁片大全|