在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DNAJC10 Antibody, HRP conjugated

  • 中文名稱:
    DNAJC10兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA809006LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DNAJC10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DNAJC10 antibody; ERDJ5 antibody; UNQ495/PRO1012DnaJ homolog subfamily C member 10 antibody; EC 1.8.4.- antibody; Endoplasmic reticulum DNA J domain-containing protein 5 antibody; ER-resident protein ERdj5 antibody; ERdj5 antibody; Macrothioredoxin antibody; MTHr antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DnaJ homolog subfamily C member 10 protein (521-793AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
  • 基因功能參考文獻:
    1. Role of ERdj5 conformational dynamics in endoplasmic reticulum associated degradation PMID: 28479060
    2. ERdj5 is a member of the proteostasis network that regulates rod opsin biogenesis and supports a role for disulfide bond formation/reduction in rod opsin biogenesis and disease. PMID: 25055872
    3. ERdj5, by binding to Sel1L, triggers BiP-Cholera toxin interaction proximal to the Hrd1 complex; postulate this scenario enables the Hrd1-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP PMID: 23363602
    4. ERdj5 acts as the endoplasmic reticulum reductase, both preparing misfolded proteins for degradation and catalyzing the folding of proteins that form obligatory non-native disulfides. PMID: 23769672
    5. ERdj5 is a ubiquitous protein localized in the ER and is particularly abundant in secretory cells. Its transcription is induced during ER stress, suggesting potential roles for ERdj5 in protein folding and translocation across the ER membrane. PMID: 12411443
    6. JPDI may have roles in folding of some proteins in the ER, chaperoning by BiP and formation of proper disulfide bonds PMID: 12446677
    7. The organization of the functional motifs of hMTHr suggests that the protein might be a member of a molecular chaperone family. PMID: 14587667
    8. ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity. PMID: 18400946
    9. study found that an endoplasmic reticulum (ER) protein ERdj5 had a reductase activity, cleaved the disulfide bonds of misfolded proteins & accelerated ER-associated degradation through its physical and functional associations with EDEM & BiP PMID: 18653895
    10. ERdj5 decreases neuroblastoma cell survival by down-regulating the UPR, raising the possibility that this protein could be a target for anti-tumor approaches. PMID: 19122239

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum lumen.
  • 數據庫鏈接:

    HGNC: 24637

    OMIM: 607987

    KEGG: hsa:54431

    STRING: 9606.ENSP00000264065

    UniGene: Hs.516632



主站蜘蛛池模板: 中文字幕精品一区二区2021年| 日韩精品国产另类专区| 国语对白刺激精品视频| 国产精品久久久久久久久鸭| 激情五月综合色婷婷一区二区| 欧美大黑帍在线播放| 国产按头口爆吞精在线视频| 国产免费极品av吧在线观看| 奇米影视第4色| 中文字幕日本特黄aa毛片| 亚洲中文字幕人成乱码| 国产成人无码a区在线观看视频 | 国产第一页浮力影院草草| 好吊色欧美一区二区三区视频| 男人扒开女人内裤强吻桶进去 | 亚洲国产高清在线一区二区三区| 秋霞国产精品一区二区| 亚洲欧美色中文字幕在线| 人妻内射一区二区在线视频| 久天啪天天久久99久久| 97久久人人超碰国产精品| 免费国偷自产拍精品视频| 国产精品成人久久电影| 免费人成网站在线观看视频| 日韩一区精品视频一区二区| 人人妻人人澡人人爽超污| 国产成人亚洲高清一区| 国产精品亚洲a∨天堂不卡| 久久精品国产99精品国产2021 | 精品国产乱码久久久久乱码| 亚洲成a∧人片在线播放调教| 国产麻豆一精品一av一免费| 亚洲欧美中文日韩v日本| 国产日韩欧美亚欧在线观看| 亚洲天天做日日做天天谢日日欢| 国产人妻aⅴ色偷| 亚洲大码熟女在线观看| 狠狠色婷婷久久综合频道毛片 | 色欲色香天天天综合网www | 国产在线一区二区在线视频| 亚洲愉拍99热成人精品热久久|