在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DNAJB11 Antibody

DNAJB11 Antibody

  • 中文名稱：
    DNAJB11兔多克隆抗體
  • 貨號(hào)：
    CSB-PA890663LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA890663LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA890663LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DNAJB11 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ABBP-2 antibody; ABBP2 antibody; APOBEC1 binding protein 2 antibody; APOBEC1-binding protein 2 antibody; DJ9 antibody; DJB11_HUMAN antibody; DnaJ (Hsp40) homolog subfamily B member 11 antibody; DnaJ homolog subfamily B member 11 antibody; DnaJ protein homolog 9 antibody; DNAJB11 antibody; EDJ antibody; ER associated DNAJ antibody; ER associated dnaJ protein 3 antibody; ER associated Hsp40 co chaperone antibody; ER-associated DNAJ antibody; ER-associated dnaJ protein 3 antibody; ER-associated Hsp40 co-chaperone antibody; ERdj3 antibody; ERJ3 antibody; ERj3p antibody; hDj-9 antibody; hDj9 antibody; HEDJ antibody; Human DnaJ protein 9 antibody; PWP1 interacting protein 4 antibody; PWP1-interacting protein 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human DnaJ homolog subfamily B member 11 protein (53-238AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，DNAJB11 Antibody (CSB-PA890663LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于DNAJB11 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA890663LB01HU DNAJB11 Antibody, HRP conjugated ELISA
    FITC CSB-PA890663LC01HU DNAJB11 Antibody, FITC conjugated
    Biotin CSB-PA890663LD01HU DNAJB11 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.
  • 基因功能參考文獻(xiàn)：
    1. DNAJB11-associated disease is a phenotypic hybrid of Autosomal-dominant polycystic kidney disease and autosomal-dominant tubulointerstitial diseases. PMID: 29706351
    2. ZAAT ER clearance resulted from enhancing ERdj3-mediated ZAAT degradation by silencing ERdj3 while simultaneously enhancing autophagy. In this context, ERdj3 suppression may eliminate the toxic gain of function associated with polymerization of ZAAT PMID: 28419579
    3. These results reveal ERdj3 tetramerization as an important structural framework for ERdj3 functions involved in coordinating endplasmic reticulum and extracellular proteostasis in the presence and absence of endplasmic reticulum stress. PMID: 28655754
    4. BiP facilitates Sec61 channel closure (i.e. limits ER Ca(2+) leakage) via the Sec61 channel with the help of ERj3 and ERj6 PMID: 26085089
    5. Depleting ERdj3 reduced the rate of mutant GCase degradation in patient-derived fibroblasts, while increasing folding, trafficking, and function by directing GCase to the profolding ER calnexin pathway. PMID: 25126989
    6. regulated co-secretion of ERdj3 with misfolded clients directly links ER and extracellular proteostasis during conditions of ER stress. PMID: 25361606
    7. ERdj3 mutant bound to unfolded endoplasmic reticulum proteins under steady state conditions in much greater amounts than wild-type. PMID: 25143379
    8. ERdjs appear to play the dual roles of increasing BiP affinity for clients and regulating delivery of clients to BiP. PMID: 23378021
    9. These data identify ERdj3 as a host protein involved with the cholera toxin intoxication process and provide new molecular details regarding cholera toxin A1-chaperone interactions. PMID: 21844235
    10. In addition, BiP formed a complex with SV40 capsids in the endoplasmic reticulum in a DNAJB11-dependent fashion. PMID: 21673190
    11. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    12. Hsp90 and Hsp40/Erdj3 were essential for K1's anti-apoptotic function. PMID: 20418907
    13. The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3. PMID: 20335166
    14. This protein was identified as true homolog of yeast Scj1p. PMID: 15195998
    15. ERdj3 is a stress-inducible endoplasmic reticulum DnaJ homologue which serves as a cofactor for BiP's interactions with unfolded substrates PMID: 15525676
    16. These data suggest that ERdj3 might have diverse roles in the ER, including that of the molecular cochaperone of BiP and an as yet unknown protective action against vero toxin.(ERDJ3) PMID: 15544163
    17. These findings suggest that the Cys-rich region of HEDJ and its oxidation state are important in maintaining the substrate interaction domain in a binding-competent conformation. PMID: 17976514
    18. Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions PMID: 19748898

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum lumen. Note=Associated with the ER membrane in a C-terminally epitope-tagged construct.
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14889

    OMIM: 611341

    KEGG: hsa:51726

    STRING: 9606.ENSP00000265028

    UniGene: Hs.317192



主站蜘蛛池模板： 日本猛少妇色xxxxx猛叫| 亚洲制服丝袜av一区二区三区| 日本大肚子孕妇交xxx| 欧美人与动牲交zooz男人| 亚洲国产精品成人午夜在线观看| 中文字字幕在线乱码视频| 人妻在客厅被c的呻吟| 男人猛吃奶女人爽视频| 精品无码一区在线观看| 亚洲最大的成人网站| 亚洲精品一线二线三线无人区| 免费无码成人av在线播放不卡| 丰满人妻被公侵犯高清版| 日韩一欧美内射在线观看| 蜜桃少妇av久久久久久久| 一本之道av不卡精品| 一区二区乱子伦在线播放| 国产国产精品人在线视| 久久性色欲av免费精品观看| 亚洲日韩va无码中文字幕| 亚洲精品久久久久久中文传媒| 亚洲国产精品无码专区成人| 国产蝌蚪视频一区二区三区| 成年性午夜免费视频网站| 亚洲精品中文字幕一区二区三区| 国产成人av片无码免费| 大肉大捧一进一出好爽动态图| 欧美牲交a欧牲交aⅴ久久| 人妻少妇精品久久| 欧美国产日韩a欧美在线观看 | 亚洲免费观看在线视频| 日本少妇自慰免费完整版| 狠狠色噜噜狠狠狠狠蜜桃| 国产精品久久自在自线青柠| 国产乱码精品一品二品| 国产精品国产精品国产专区不卡| 国内精品自在自线视频| 97性无码区免费| 天堂官网在线资源网| 久久久久人妻精品一区三寸| 国内精品国产三级国产av|