在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DNAJB11 Antibody, Biotin conjugated

  • 中文名稱:
    DNAJB11兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA890663LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DNAJB11 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ABBP-2 antibody; ABBP2 antibody; APOBEC1 binding protein 2 antibody; APOBEC1-binding protein 2 antibody; DJ9 antibody; DJB11_HUMAN antibody; DnaJ (Hsp40) homolog subfamily B member 11 antibody; DnaJ homolog subfamily B member 11 antibody; DnaJ protein homolog 9 antibody; DNAJB11 antibody; EDJ antibody; ER associated DNAJ antibody; ER associated dnaJ protein 3 antibody; ER associated Hsp40 co chaperone antibody; ER-associated DNAJ antibody; ER-associated dnaJ protein 3 antibody; ER-associated Hsp40 co-chaperone antibody; ERdj3 antibody; ERJ3 antibody; ERj3p antibody; hDj-9 antibody; hDj9 antibody; HEDJ antibody; Human DnaJ protein 9 antibody; PWP1 interacting protein 4 antibody; PWP1-interacting protein 4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DnaJ homolog subfamily B member 11 protein (53-238AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.
  • 基因功能參考文獻:
    1. DNAJB11-associated disease is a phenotypic hybrid of Autosomal-dominant polycystic kidney disease and autosomal-dominant tubulointerstitial diseases. PMID: 29706351
    2. ZAAT ER clearance resulted from enhancing ERdj3-mediated ZAAT degradation by silencing ERdj3 while simultaneously enhancing autophagy. In this context, ERdj3 suppression may eliminate the toxic gain of function associated with polymerization of ZAAT PMID: 28419579
    3. These results reveal ERdj3 tetramerization as an important structural framework for ERdj3 functions involved in coordinating endplasmic reticulum and extracellular proteostasis in the presence and absence of endplasmic reticulum stress. PMID: 28655754
    4. BiP facilitates Sec61 channel closure (i.e. limits ER Ca(2+) leakage) via the Sec61 channel with the help of ERj3 and ERj6 PMID: 26085089
    5. Depleting ERdj3 reduced the rate of mutant GCase degradation in patient-derived fibroblasts, while increasing folding, trafficking, and function by directing GCase to the profolding ER calnexin pathway. PMID: 25126989
    6. regulated co-secretion of ERdj3 with misfolded clients directly links ER and extracellular proteostasis during conditions of ER stress. PMID: 25361606
    7. ERdj3 mutant bound to unfolded endoplasmic reticulum proteins under steady state conditions in much greater amounts than wild-type. PMID: 25143379
    8. ERdjs appear to play the dual roles of increasing BiP affinity for clients and regulating delivery of clients to BiP. PMID: 23378021
    9. These data identify ERdj3 as a host protein involved with the cholera toxin intoxication process and provide new molecular details regarding cholera toxin A1-chaperone interactions. PMID: 21844235
    10. In addition, BiP formed a complex with SV40 capsids in the endoplasmic reticulum in a DNAJB11-dependent fashion. PMID: 21673190
    11. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    12. Hsp90 and Hsp40/Erdj3 were essential for K1's anti-apoptotic function. PMID: 20418907
    13. The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3. PMID: 20335166
    14. This protein was identified as true homolog of yeast Scj1p. PMID: 15195998
    15. ERdj3 is a stress-inducible endoplasmic reticulum DnaJ homologue which serves as a cofactor for BiP's interactions with unfolded substrates PMID: 15525676
    16. These data suggest that ERdj3 might have diverse roles in the ER, including that of the molecular cochaperone of BiP and an as yet unknown protective action against vero toxin.(ERDJ3) PMID: 15544163
    17. These findings suggest that the Cys-rich region of HEDJ and its oxidation state are important in maintaining the substrate interaction domain in a binding-competent conformation. PMID: 17976514
    18. Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions PMID: 19748898

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum lumen. Note=Associated with the ER membrane in a C-terminally epitope-tagged construct.
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 14889

    OMIM: 611341

    KEGG: hsa:51726

    STRING: 9606.ENSP00000265028

    UniGene: Hs.317192



主站蜘蛛池模板: 日韩精品人涩人| 国产无遮挡又黄又爽免费网站| a国产在线v的不卡视频| 亚洲精品无码不卡在线播放he| 狠狠色噜噜狠狠狠狠五月婷| 色老板精品视频在线观看| 久久久www成人免费精品| 精品久久久久久777米琪桃花| 国产成人精品手机在线观看| 欧美成人猛片aaaaaaa| 亚洲欧美日韩中文无线码| 日本真人边吃奶边做爽动态图| 欧美亚洲高清国产| 久久久精品午夜免费不卡| 久久精品国产一区二区三区| 日本成本人三级在线观看| 伊人久久大香线蕉综合中文字幕| 久久躁狠狠躁夜夜av| 亚洲中文在线播放一区| 亚洲最大无码中文字幕网站| 精品乱人伦一区二区三区| 欧美性大战久久久久久| 精品高朝久久久久9999| 玩弄人妻少妇老师美妇厨房| 任我爽精品视频在线播放| 精品人妻一区二区三区四区在线| 久久午夜色播影院| 国产色无码精品视频免费| 亚洲 精品 综合 精品 自拍| 国产日韩另类综合11页| 强制高潮18xxxxhd日韩| 国产精品.xx视频.xxtv| 亚洲这里只有久热精品伊人| 久久久久久九九精品久| 少妇人妻偷人精品视频| 国产99久久久久久免费看| 日韩人妻无码精品系列| 又大又紧又粉嫩18p少妇| 久久久久se色偷偷亚洲精品av| 免费看美女部位隐私网站| 中文字幕亚洲综合久久蜜桃|