在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DNAH1 Antibody, Biotin conjugated

  • 中文名稱:
    DNAH1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA878961LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) DNAH1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DNAH1 antibody; DHC7 antibody; DNAHC1 antibody; KIAA1410 antibody; Dynein heavy chain 1 antibody; axonemal antibody; Axonemal beta dynein heavy chain 1 antibody; Ciliary dynein heavy chain 1 antibody; Heat shock regulated protein 1 antibody; HSRF-1 antibody; hDHC7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dynein heavy chain 1, axonemal protein (2225-2407AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme.
  • 基因功能參考文獻:
    1. DNAH1 variations were identified in 6 of 287 patients, including 8 heterozygous variations in exons and a splicing site. 4 variations (g.52400764G>C, g.52409336C>T, g.52430999_52431000del, g.52412624C>A) had already been registered in the 1000 Genomes and Exome Aggregation Consortium databases. The other novel variations (g.52418050del, g.52404762T>G, g.52430536del, g.52412620del) were all predicted to be pathogenic. PMID: 30544445
    2. Pedigree analysis supported the notion that the combination of DNAH1 gene mutations 52430998CCT>C and 52409336C>T and 52428484G>T alone were associated with MMAF. CONCLUSION(S): These DNAH1 gene mutations may be associated with DFS and infertility in the Han population. PMID: 28577616
    3. This mutation was distinct from previously reported DNAH1 mutations associated with MMAF and only affected the East Asian group. Furthermore, the variant DNAH1 protein could not be detected in spermatozoa by Western blot or immunofluorescence staining although DNAH1 mRNA was expressed in the spermatozoa. PMID: 27573432
    4. variation in DNAH1 may play a role in primary ciliary dyskinesia PMID: 25927852
    5. Although DNAH1 is expressed in other ciliated cells, infertility was the only symptom of primary ciliary dyskinesia observed in affected subjects, suggesting that DNAH1 function in cilium is not as critical as in sperm flagellum. PMID: 24360805
    6. Male carriers of the mutations always exhibit asthenozoospermia, whereas female carriers manifest no alterations in either fertility or pulmonary clearance. PMID: 18492703
    7. Dynein motor function is important for regulating Gag and viral RNA egress on endosomal membranes in the cytoplasm to directly impact on viral production. PMID: 19286658
    8. clathrin serving as a regulator of SNX4-dependent transport; upon clathrin release, dynein may bind SNX4 and mediate retrograde movement PMID: 19529763

    顯示更多

    收起更多

  • 相關疾病:
    Spermatogenic failure 18 (SPGF18); Ciliary dyskinesia, primary, 37 (CILD37)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum.
  • 蛋白家族:
    Dynein heavy chain family
  • 組織特異性:
    Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2940

    OMIM: 603332

    KEGG: hsa:25981

    STRING: 9606.ENSP00000401514

    UniGene: Hs.655469



主站蜘蛛池模板: 国产精品高潮呻吟av久久小说| 7777久久亚洲中文字幕| 久久久亚洲精品无码| 狠狠色老熟妇老熟女| 久久国产av影片| 伦埋琪琪电影院久久| 高清情侣国语自产拍| 欧美成人综合久久精品| 丰满人妻被黑人中出849| 欧美18videosex性欧美黑吊| 奇米影视第四色首页| 国产a三级久久精品| 亚洲国产成人高清影视| 国内精品久久久久影院日本| 美女高潮黄又色高清视频免费| 好了av在线第四综合网站| 艳妇乳肉豪妇荡乳在线观看 | 中文字幕无码乱人伦| 青娱乐极品视觉盛宴av| 久久99国产综合精品女同| 国产末成年女av片一区二区| 野外做受又硬又粗又大视频| 色欲色香天天天综合无码| 国产精品亚洲mnbav网站| 欧美怡红院免费全部视频| 久久久久久av无码免费网站下载 | 亚洲国产精品无码中文lv| 人人妻人人玩人人澡人人爽| 国产又爽又黄无码无遮挡在线观看 | 欧美精品无码久久久久久| 99精品电影一区二区免费看| 亚洲熟女乱综合一区二区在线| 99久久九九社区精品| 亚洲国产精品久久久久久无码| 久久九九av免费精品| 亚洲欧洲成人a∨在线观看 | 日本免费人成在线观看网站| 中国无码人妻丰满熟妇啪啪软件| 国产精品亚洲一区二区无码| 国产饥渴孕妇在线播放| 无码毛片内射白浆视频|