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  4. DMXL2 Antibody, Biotin conjugated

DMXL2 Antibody, Biotin conjugated

  • 中文名稱：
    DMXL2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA819469LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DMXL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DMXL2
  • 別名：
    DmX-like protein 2 antibody; Dmxl2 antibody; DMXL2_HUMAN antibody; KIAA0856 antibody; Rabconnectin-3 antibody; RC3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DmX-like protein 2 protein (2471-2657AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes.
  • 基因功能參考文獻：
    1. Data indicated that the p.Arg2417His variant in DMXL2 is associated with dominant, nonsyndromic hearing loss and suggested an important role of DMXL2 in inner ear function. PMID: 27657680
    2. authors demonstrate that DMXL2 is a transmembrane protein with a potential extra-cellular domain. These findings identify DMXL2 as a novel, functional biomarker for ERalpha positive breast cancer. PMID: 26093085
    3. Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice. PMID: 25248098
    4. an important role for Rabconnectin-3 and V-ATPase activity in the Notch signaling pathway in mammalian cells. PMID: 20810660
  • 相關疾病：
    Polyendocrine-polyneuropathy syndrome (PEPNS); Deafness, autosomal dominant, 71 (DFNA71)
  • 亞細胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
  • 數據庫鏈接：

    HGNC: 2938

    OMIM: 612186

    KEGG: hsa:23312

    STRING: 9606.ENSP00000441858

    UniGene: Hs.511386



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