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DMGDH Antibody

  • 中文名稱:
    DMGDH兔多克隆抗體
  • 貨號:
    CSB-PA002163
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of A549 cells using DMGDH Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DMGDH
  • 別名:
    Dimethylglycine dehydrogenase antibody; Dimethylglycine dehydrogenase; mitochondrial antibody; Dmgdh antibody; M2GD_HUMAN antibody; ME2GLYDH antibody; mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human DMGDH.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro.
  • 基因功能參考文獻:
    1. In nonalcoholic fatty liver disease patient, the missense variant p.Ser646Pro (rs1805074) in DMGDH gene was significantly associated with disease severity and circulating levels of dimethylglycine. PMID: 27614103
    2. The structure-based analysis provided new insights into the kinetic properties of dimethylglycine dehydrogenase in particular with respect to oxygen reactivity. PMID: 27486859
    3. In agreement with previous studies, we show that the genetic variant rs921943 in DMGDH is significantly associated with selenium status in United Kingdom pregnant women. PMID: 26675765
    4. Genetic variation of DMGDH was associated with higher plasma insulin, increased insulin resistance and increased risk of incident diabetes. PMID: 25795213
    5. analysis of dimethylglycine dehydrogenase deficiency associated with pathogenic variant H109R PMID: 18937046

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  • 相關疾病:
    DMGDH deficiency (DMGDHD)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    GcvT family
  • 數據庫鏈接:

    HGNC: 24475

    OMIM: 605849

    KEGG: hsa:29958

    STRING: 9606.ENSP00000255189

    UniGene: Hs.655653



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