在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DMC1 Antibody

  • 中文名稱:
    DMC1兔多克隆抗體
  • 貨號:
    CSB-PA006962GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DMC1
  • 別名:
    Disrupted meiotic cDNA 1 homolog antibody; Disrupted meiotic cDNA 1; yeast; homolog of antibody; dJ199H16.1 antibody; DMC 1 antibody; DMC1 antibody; DMC1 dosage suppressor of mck1 homolog antibody; DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast) antibody; DMC1 homologue antibody; DMC1_HUMAN antibody; DMC1H antibody; DNA meiotic recombinase 1 antibody; HsLim15 antibody; LIM15 antibody; Meiotic recombination protein DMC1/LIM15 homolog antibody; MGC150472 antibody; MGC150473 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DMC1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
  • 基因功能參考文獻:
    1. Data indicate that ahomologous pairing by DMC1 protein or RAD51 recombinase in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions. PMID: 27052786
    2. BRCA2 protein stimulates DMC1-mediated DNA strand exchange between RPA-ssDNA complexes and duplex DNA, thus identifying BRCA2 as a mediator of DMC1 recombination function. PMID: 26976601
    3. Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence. PMID: 26709229
    4. In contrast to RAD51, stabilization of the presynaptic filament via ATP hydrolysis attenuation is insufficient for enhancement of the DMC1-catalyzed recombination reaction. PMID: 26088134
    5. truncated DMC1 octamers further stack with alternate polarity into a filament PMID: 23545642
    6. results suggested mutations in the coding sequence of DMC1 are not associated with premature ovarian failure in Chinese women PMID: 23265958
    7. conserved lysine in the Walker A motif of hDMC1 is critical for ATP binding. PMID: 23182424
    8. The results suggested that PSF may function as an activator for the meiosis-specific recombinase DMC1. PMID: 22156371
    9. D-loops in a human DMC1-driven reaction are substantially more resistant to dissociation by branch-migration proteins such as RAD54 than those formed by RAD51. PMID: 21151113
    10. the Dmc1 filament formed on single-stranded DNA has a mass per unit length expected from approximately 6.5 subunits per turn PMID: 20600108
    11. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells PMID: 14764457
    12. The monomeric structure of the Dmc1 protein closely resembled those of the human and archaeal Rad51 proteins. We found another hydrogen bonding interaction at the polymer interface. PMID: 15125839
    13. hDmc1-mediated DNA recombination initiates through the nucleation of hDmc1 onto ssDNA to form a helical nucleoprotein filament PMID: 15164066
    14. N-terminal domain of DMC1 is required for the formation of the octamer, which may support the proper DNA binding activity of the DMC1 protein. PMID: 15917243
    15. activation of hDmc1 is mediated through conformational changes induced by free Ca2+ ion binding to a protein site that is distinct from the Mg2+.ATP-binding center PMID: 15917244
    16. BRCA2 binds the meiosis-specific recombinase DMC1 and define the primary DMC1 interaction site to a 26 amino-acid region PMID: 17541404
    17. Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs PMID: 17639081
    18. Data show that DMC1 mutations may be one explanation for premature ovarian failure. PMID: 18166824
    19. The interaction of DMC1 and the homologue of the large subunit of CAF-1 is reported. PMID: 18355319
    20. Results indicate that Rad51 and Dmc1 filaments are essentially identical with respect to several structural parameters, including persistence length, helical pitch, filament diameter, DNA base pairs per helical turn and helical handedness. PMID: 18535008
    21. Biochemical analyses revealed that the human DMC1-M200V variant had reduced stability, and was moderately defective in catalyzing in vitro recombination reactions. PMID: 18566005
    22. Reversibility, equilibration, and fidelity of strand exchange reaction between short oligonucleotides promoted by RecA protein from escherichia coli and human Rad51 and Dmc1 proteins. PMID: 19004837
    23. DMC1-I37N polymorphism may be a source of improper meiotic recombination, causing meiotic defects in humans PMID: 19076215

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    RecA family, DMC1 subfamily
  • 數據庫鏈接:

    HGNC: 2927

    OMIM: 602721

    KEGG: hsa:11144

    STRING: 9606.ENSP00000216024

    UniGene: Hs.339396



主站蜘蛛池模板: 国外亚洲成av人片在线观看 | 久久精品国产网红主播| 成人区人妻精品一熟女| 免费男人下部进女人下部视频 | 乌克兰美女浓毛bbw| 在线精品国产一区二区三区| 成人免费看片又大又黄| 欧美成人免费全部观看国产| 国产一区二区不卡在线看| 国产无遮挡又黄又爽高潮| 久久亚洲精品11p| 久艹视频免费看| 免费毛片在线看片免费丝瓜视频| 国产日韩在线视看第一页 | 自慰无码一区二区三区| 亚洲精品无码久久久久久久| 亚洲最新无码成av人| 久久国产亚洲精选av| 欧美激情视频一区二区三区免费 | 国产激情久久久久久熟女老人| 亚洲成a人片在线观看无码下载| 国产国拍亚洲精品av| 欧美日韩不卡合集视频| 无尺码精品产品日韩| 中文字幕丰满伦子无码| 亚洲第一a在线观看网站| 强行糟蹋人妻hd中文字幕 | 亚洲一区二区三区国产精华液| 人人做人人爽国产视| 亚洲国产丝袜精品一区| 无码粉嫩虎白一线天在线观看| 亚洲这里只有久热精品伊人| 免费国产午夜视频在线观看 | 国产成人午夜福利在线观看视频| 777米奇色狠狠俺去啦| 国产精品久久久久无码av色戒| 中文字幕亚洲乱码熟女一区二区| 久久久女人与动物群交毛片 | 日韩久久久久久中文人妻| 国产乱码精品一区二区三区中文| 欧美大片18禁aaa免费视频|