在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DMC1 Antibody, Biotin conjugated

  • 中文名稱:
    DMC1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA617920LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) DMC1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DMC1
  • 別名:
    Disrupted meiotic cDNA 1 homolog antibody; Disrupted meiotic cDNA 1; yeast; homolog of antibody; dJ199H16.1 antibody; DMC 1 antibody; DMC1 antibody; DMC1 dosage suppressor of mck1 homolog antibody; DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast) antibody; DMC1 homologue antibody; DMC1_HUMAN antibody; DMC1H antibody; DNA meiotic recombinase 1 antibody; HsLim15 antibody; LIM15 antibody; Meiotic recombination protein DMC1/LIM15 homolog antibody; MGC150472 antibody; MGC150473 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Meiotic recombination protein DMC1/LIM15 homolog protein (5-153AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
  • 基因功能參考文獻(xiàn):
    1. Data indicate that ahomologous pairing by DMC1 protein or RAD51 recombinase in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions. PMID: 27052786
    2. BRCA2 protein stimulates DMC1-mediated DNA strand exchange between RPA-ssDNA complexes and duplex DNA, thus identifying BRCA2 as a mediator of DMC1 recombination function. PMID: 26976601
    3. Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence. PMID: 26709229
    4. In contrast to RAD51, stabilization of the presynaptic filament via ATP hydrolysis attenuation is insufficient for enhancement of the DMC1-catalyzed recombination reaction. PMID: 26088134
    5. truncated DMC1 octamers further stack with alternate polarity into a filament PMID: 23545642
    6. results suggested mutations in the coding sequence of DMC1 are not associated with premature ovarian failure in Chinese women PMID: 23265958
    7. conserved lysine in the Walker A motif of hDMC1 is critical for ATP binding. PMID: 23182424
    8. The results suggested that PSF may function as an activator for the meiosis-specific recombinase DMC1. PMID: 22156371
    9. D-loops in a human DMC1-driven reaction are substantially more resistant to dissociation by branch-migration proteins such as RAD54 than those formed by RAD51. PMID: 21151113
    10. the Dmc1 filament formed on single-stranded DNA has a mass per unit length expected from approximately 6.5 subunits per turn PMID: 20600108
    11. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells PMID: 14764457
    12. The monomeric structure of the Dmc1 protein closely resembled those of the human and archaeal Rad51 proteins. We found another hydrogen bonding interaction at the polymer interface. PMID: 15125839
    13. hDmc1-mediated DNA recombination initiates through the nucleation of hDmc1 onto ssDNA to form a helical nucleoprotein filament PMID: 15164066
    14. N-terminal domain of DMC1 is required for the formation of the octamer, which may support the proper DNA binding activity of the DMC1 protein. PMID: 15917243
    15. activation of hDmc1 is mediated through conformational changes induced by free Ca2+ ion binding to a protein site that is distinct from the Mg2+.ATP-binding center PMID: 15917244
    16. BRCA2 binds the meiosis-specific recombinase DMC1 and define the primary DMC1 interaction site to a 26 amino-acid region PMID: 17541404
    17. Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs PMID: 17639081
    18. Data show that DMC1 mutations may be one explanation for premature ovarian failure. PMID: 18166824
    19. The interaction of DMC1 and the homologue of the large subunit of CAF-1 is reported. PMID: 18355319
    20. Results indicate that Rad51 and Dmc1 filaments are essentially identical with respect to several structural parameters, including persistence length, helical pitch, filament diameter, DNA base pairs per helical turn and helical handedness. PMID: 18535008
    21. Biochemical analyses revealed that the human DMC1-M200V variant had reduced stability, and was moderately defective in catalyzing in vitro recombination reactions. PMID: 18566005
    22. Reversibility, equilibration, and fidelity of strand exchange reaction between short oligonucleotides promoted by RecA protein from escherichia coli and human Rad51 and Dmc1 proteins. PMID: 19004837
    23. DMC1-I37N polymorphism may be a source of improper meiotic recombination, causing meiotic defects in humans PMID: 19076215

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    RecA family, DMC1 subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2927

    OMIM: 602721

    KEGG: hsa:11144

    STRING: 9606.ENSP00000216024

    UniGene: Hs.339396



主站蜘蛛池模板: 国产精品对白交换视频| 99久re热视频这里只有精品6| 欧美日产国产新一区| 国产美女午夜福利视频| 国产山东熟女48嗷嗷叫| 亚洲人成色77777在线观看大战p| 欧美牲交a欧美牲交aⅴ免费真 | 欧美牲交a欧美牲交aⅴ另类| 午夜婷婷精品午夜无码a片影院| 真实国产乱子伦在线视频| 国产精品视频二区不卡| 亚洲日韩国产av无码无码精品| 婷婷五月深深久久精品| 久久久综合九色综合鬼色| 欧美精品久久96人妻无码| 国产二级一片内射视频插放| 好爽…又高潮了免费毛片| 真实国产精品vr专区| 久久天堂av综合合色| 爽爽影院免费观看视频| 成人网站免费观看入口| 中国熟妇毛多多裸交视频| 又紧又黄的免费视频网站| 久久狠狠高潮亚洲精品| 成人无遮羞视频在线观看| 国产av国片精品一区二区| 无码国产成人午夜电影在线观看| 午夜精品一区二区三区的区别| 久久亚洲一区二区三区四区五区 | 影音先锋无码aⅴ男人资源站| 骚片av蜜桃精品一区| 人妻无码vs中文字幕久久av爆| av一区二区国产在线视频| 337p日本欧洲亚洲大胆| 国产成人综合欧美精品久久| 亚洲国产成人精品无码一区二区| 久久中文骚妇内射| 亚洲国产成人一区二区精品区| 国产毛片精品av一区二区| 亚洲一卡2卡3卡4卡5卡精品| 久久精品国产99精品国产亚洲性色 |