在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DKK2 Antibody

  • 中文名稱:
    DKK2兔多克隆抗體
  • 貨號:
    CSB-PA284301
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse lung tissue, Primary antibody: CSB-PA284301(DKK2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Dickkopf 2 antibody; Dickkopf gene 2 antibody; Dickkopf homolog 2 antibody; Dickkopf related protein 2 antibody; Dickkopf WNT signaling pathway inhibitor 2 antibody; Dickkopf-2 antibody; Dickkopf-related protein 2 antibody; Dickkopf2 antibody; DKK 2 antibody; Dkk-2 antibody; Dkk2 antibody; DKK2_HUMAN antibody; hDkk 2 antibody; hDkk-2 antibody; hDkk2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human DKK2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 基因功能參考文獻:
    1. our findings demonstrate that DKK2 functions as a tumor suppressor through inhibiting cell proliferation and inducing apoptosis via regulating Wnt signaling during breast tumorigenesis. PMID: 28467796
    2. Knock down of the dickkopf WNT signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11 and HOXD13 while over-expression of DKK2 and stimulation with factors of the WNT signaling pathway. PMID: 27363011
    3. epigenetic silencing of Wnt antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 could be a potential marker for a prognosis of poor overall survival. PMID: 28152305
    4. the genotyping and functional findings are consistent with the hypothesis that DKK2 is a tumor suppressor; by selectively retaining a transcriptionally inactive DKK2 allele, the reduction of DKK2 function results in unchecked Wnt/beta-catenin signaling, contributing to hepatocellular carcinoma oncogenesis. PMID: 27203079
    5. The present report suggested that DKK2 downregulation suppressed the proliferation and invasion of prostate cancer cells by inhibiting the Wnt/betacatenin signaling pathway. PMID: 27431620
    6. these findings reveal that the miR-187-5p-DKK2 pathway regulates Wnt/beta-catenin signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR-187-5p in promotion of B-cell ALL. PMID: 27296949
    7. Genetic variant in DKK2 gene is associated with gallbladder cancer. PMID: 26715268
    8. targeting of DKK2 by miR-154 leads to upregulation of beta-catenin expression and activation of the classical Wnt signaling pathway and cardiac fibroblasts. PMID: 27542661
    9. MiR-21 overexpression was significantly correlated with the DKK2-/beta-catenin- immunohistochemical phenotype. PMID: 23999978
    10. Data indicate that inhibiting dickkopf-related protein 2 (DKK2)with siDKK2 reduced the expression of DKK2, but had no effect on leptin expression. PMID: 25312721
    11. We found 1 DKK2 SNP to be significantly associated with alcohol-related harm in alcoholic subjects PMID: 24117450
    12. a new regulatory mechanism of miR-222 PMID: 23587485
    13. Our results provide strong evidence that DKK2 is a key player in Ewing sarcoma invasion and osteolysis and also in the differential phenotype of Ewing sarcoma cells. PMID: 23204234
    14. DKK2 may contribute to tumorigenesis in epithelial ovarian cancer(EOC) through the Wnt/beta-catenin signaling mechanisms. PMID: 22964660
    15. Elevated TGF-beta1 levels in osteoarthritic osteoblasts can stimulate DKK2 expression. PMID: 21312269
    16. In the study of the genetics of alcoholism, three SNPs in DKK2 (rs427983; rs419558; rs399087) demonstrated empirical significance. PMID: 20332099
    17. DKK2 is epigenetically silenced by methylation in higher grades and stages of renal cell carcinoma; results suggest that DKK2 inhibits renal cancer progression through apoptotic and cell cycle pathways PMID: 19755393
    18. Analysis of individual Dkk domains and chimeric Dkks shows that the carboxy-terminal domains of both Dkk1 & 2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. PMID: 12167704
    19. analysis of the structural basis of the interaction between Dkk and low density lipoprotein receptor-related protein (LRP) 5/6 PMID: 18524778

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Dickkopf family
  • 組織特異性:
    Expressed in heart, brain, skeletal muscle and lung.
  • 數據庫鏈接:

    HGNC: 2892

    OMIM: 605415

    KEGG: hsa:27123

    STRING: 9606.ENSP00000285311

    UniGene: Hs.211869



主站蜘蛛池模板: 欧美日韩人成视频在线播放| 精品无人区一区二区三区| 一本大道一卡2卡三卡4卡国产| 麻豆国产丝袜白领秘书在线观看| 日本高清视频wwww色| 特黄大片又粗又大又暴| 亚洲日韩精品一区二区三区无码| 国产精品美女久久久浪潮av| 国产精品无码专区第一页| 韩国精品一区二区无码视频| 女人18毛片水真多免费看| 欧美激烈精交gif动态图| 国产综合色在线精品| 97人妻人人揉人人躁人人| 久久亚洲人成综合网| 国产性夜夜春夜夜爽免费下载| 亚洲成在人线在线播放无码| 内射毛片内射国产夫妻| 麻豆果冻精东九一传媒mv| 国产精品无码翘臀在线看| 少妇太爽了在线观看| 西西人体大胆午夜啪啪| 女人夜夜春高潮爽a∨片传媒| 国产精品无码午夜免费影院| 脱了美女内裤猛烈进入gif| 国产精品美女乱子伦高| 日韩免费无砖专区2020狼 | 亚洲欧洲中文日韩久久av乱码| 国内揄拍国内精品少妇国语| 国产精品高潮呻吟av久久小说| 伊人婷婷六月狠狠狠去| 麻豆av福利av久久av| 重口sm一区二区三区视频| 2018av无码视频在线播放| 日韩人妻无码精品久久久不卡| 亚洲综合国产一区二区三区| 高潮爽死抽搐白浆gif视频| 欧美性猛交xxxx黑人猛交| 欧美成人一区二免费视频软件 | 日本精品人妻无码77777| 国语精品福利自产拍在线观看|