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  4. DHX15 Antibody

DHX15 Antibody

  • 中文名稱：
    DHX15兔多克隆抗體
  • 貨號：
    CSB-PA006870GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DHX15
  • 別名：
    ATP dependent RNA helicase #46 antibody; ATP-dependent RNA helicase #46 antibody; DBP1 antibody; DDX15 antibody; DEADH box 15 antibody; DEAH (Asp Glu Ala His) box polypeptide 15 antibody; DEAH box polypeptide 15 antibody; DEAH box protein 15 antibody; DHX15 antibody; DHX15_HUMAN antibody; HRH2 antibody; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 antibody; PRP43 antibody; PrPp43p antibody; RNA helicase 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DHX15
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.
  • 基因功能參考文獻：
    1. DHX15 regulates androgen receptor (AR) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression. PMID: 28991234
    2. The crystal structure of human DHX15 reveals a domain organization of the mammalian DEAH/RHA family. PMID: 28580923
    3. Loss of DHX15 expression is associated with glioma. PMID: 28829764
    4. depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. PMID: 28115624
    5. Mutation in DHX15 is associated with core-binding factor acute myeloid leukemia. PMID: 27798625
    6. Data indicate that DEAH-box RNA helicase DHX15/PRP43 stimulates the NF-kappaB and MAPK pathways downstream of virus-induced signaling adapter protein MAVS and contributes to MAVS-mediated cytokine production and apoptosis. PMID: 24782566
    7. The results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. PMID: 24823796
    8. Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner. PMID: 22569250

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  • 亞細胞定位：
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily, DDX15/PRP43 sub-subfamily
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 2738

    OMIM: 603403

    KEGG: hsa:1665

    STRING: 9606.ENSP00000336741

    UniGene: Hs.696074



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