在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DBF4 Antibody

  • 中文名稱:
    DBF4兔多克隆抗體
  • 貨號:
    CSB-PA887010LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA887010LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DBF4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Activator of S phase kinase antibody; ASK antibody; CHIF antibody; Chiffon homolog A antibody; DBF4 antibody; DBF4 homolog (S. cerevisiae) antibody; DBF4 homolog antibody; DBF4 type zinc finger containing protein 1 antibody; DBF4 zinc finger A antibody; DBF4 zinc finger antibody; DBF4; S. cerevisiae; homolog of antibody; DBF4-type zinc finger-containing protein 1 antibody; DBF4A antibody; DBF4A_HUMAN antibody; Dumbbell former 4; S. cerevisiae; homolog of antibody; OTTHUMP00000161661 antibody; Protein DBF4 homolog A antibody; ZDBF1 antibody; Zinc finger; DBF-type containing 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein DBF4 homolog A protein (101-281AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,DBF4 Antibody (CSB-PA887010LA01HU),的標記方式是Non-conjugated。對于DBF4 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA887010LB01HU DBF4 Antibody, HRP conjugated ELISA
    FITC CSB-PA887010LC01HU DBF4 Antibody, FITC conjugated
    Biotin CSB-PA887010LD01HU DBF4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
  • 基因功能參考文獻:
    1. Both CDC7 and DBF4 promoters bind E2F, suggesting that increased E2F activity in RB1 mutant cancers promotes increased DDK expression. Surprisingly, increased DDK expression levels are also correlated with both increased chemoresistance and genome-wide mutation frequencies. PMID: 28448802
    2. Histone H3 lysine 9 (H3K9) acetylation was most prevalent when the Dbf4 transcription level was highest whereas the H3K9me3 level was greatest during and just after replication. PMID: 27341472
    3. we propose that phosphorylation of TOP2A by CDC7/DBF4 in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A function could be relevant to prevent premature separation of centromeric DNA. PMID: 27407105
    4. The anti-invasive and cell cycle arrest-inducing effects of nitrogen-containing bisphosphonates are not DBF4 mediated in human breast cancer cells. PMID: 24287290
    5. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. PMID: 22123827
    6. bipartite interaction between Cdc7 and Dbf4/ASK subunits facilitates ATP binding and substrate recognition by the Cdc7 kinase. PMID: 21536671
    7. Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction PMID: 21036905
    8. Data document the role of DBF4 as a key player in nitrogen-containing bisphosphonate-induced cytotoxicity, thus explaining the effects on the cell-cycle. PMID: 19744312
    9. The interaction with LEDGF relieves autoinhibition of Cdc7-ASK kinase, imposed by the C terminus of ASK. PMID: 19864417
    10. results suggest that E2F regulates the ASK promoter through an atypical mode of recognition of the target site PMID: 12015319
    11. The HuDbf4 gene has of 12 exons over a 33-kb region. The MluI cell-cycle box is needed for core promoter activation. The Sp1 upregulator & HES-1 repressor coordinately determine promoter efficiency. Transcription initiations occur at -220, -235 and -245. PMID: 12420215
    12. Results demonstrate a DNA damage checkpoint that targets Cdc7/Dbf4 protein kinase. PMID: 12535533
    13. Cdc7-Dbf4 kinase efficiently phosphorylates p150. PMID: 16826239
    14. Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. PMID: 16899510
    15. Overexpression of Dbf4 abrogates the S checkpoint response to ultraviolet radiation but not ionizing radiation. PMID: 17276990
    16. There is the differential regulation of a novel gene, namely ASK/Dbf4, in melanoma and suggest that up-regulation of ASK/Dbf4 is a novel molecular determinant with prognostic relevance that confers a proliferative advantage in cutaneous melanoma. PMID: 17768177
    17. Cdc7/Dbf4 kinase activity inhibition affects specific phosphorylation sites on MCM2 in cancer cells PMID: 18286467
    18. ASK/Dbf4, a novel cell survival gene in melanoma is transcriptionally regulated by E2F1. PMID: 18503552
    19. A strong origin of replication at the DBF4 promoter locus, which contains two initiation zones, two origin recognition complex (ORC) binding sites and two DNase I-hypersensitive regions, is identified. PMID: 18536724
    20. increased Cdc7-Dbf4 abundance may be a common occurrence in human malignancies PMID: 18714392
    21. These results indicate that Ddk functions as an upstream regulator to monitor S-phase checkpoint signaling. PMID: 19111665

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
  • 數據庫鏈接:

    HGNC: 17364

    OMIM: 604281

    KEGG: hsa:10926

    STRING: 9606.ENSP00000265728

    UniGene: Hs.485380



主站蜘蛛池模板: 亚洲中文字幕无码不卡电影| 东京一本一道一二三区| 99精品视频在线观看免费蜜桃| 精品无码久久久久国产app| 男人j桶进女人p无遮挡免费观看| 天天av天天爽无码中文| 色综合网天天综合色中文| 久久男人av资源网站| 国色天香在线视频www| 亚洲精品夜夜夜| а√天堂资源中文在线官网| 一本一道久久综合久久| 99热精国产这里只有精品| 精品久久久久久人妻无码中文字幕| 亚洲精品一区中文字幕乱码| 日韩亚洲中字无码一区二区三区 | 新国产三级视频在线播放| 男女超爽视频免费播放| 亚洲亚洲人成无码网www| 亚洲旡码欧美大片| 亚洲日韩成人无码| 久久国内精品自在自线| 国产精品国产对白熟妇| 亚洲人色婷婷成人网站在线观看 | 日韩在线不卡免费视频一区| 国内精品伊人久久久久777| av狼友无码国产在线观看| 亚洲精品国男人在线视频| 日韩欧美在线综合网| 寂寞骚妇被后入式爆草抓爆| 麻豆丰满少妇chinese| 亚洲一区二区三区中文字幕在线| 99久久婷婷国产综合精品青草免费| 综合图区亚洲另类偷窥| 日本少妇浓毛bbwbbwbbw| 夫妻免费无码v看片| 精品亚洲成a人片在线观看少妇| 午夜福利一区二区三区高清视频 | 日韩不卡1卡2卡三卡2021精品推荐| 久久久日韩精品一区二区 | 好了av第四综合无码久久|