在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DBF4 Antibody

  • 中文名稱:
    DBF4兔多克隆抗體
  • 貨號:
    CSB-PA113425
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from NIH-3T3 cells treated with H2O2 (100uM, 30mins) and COS-7 cells treated with PMA (125mg/ml, 30mins), using DBF4 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DBF4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human DBF4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
  • 基因功能參考文獻:
    1. Both CDC7 and DBF4 promoters bind E2F, suggesting that increased E2F activity in RB1 mutant cancers promotes increased DDK expression. Surprisingly, increased DDK expression levels are also correlated with both increased chemoresistance and genome-wide mutation frequencies. PMID: 28448802
    2. Histone H3 lysine 9 (H3K9) acetylation was most prevalent when the Dbf4 transcription level was highest whereas the H3K9me3 level was greatest during and just after replication. PMID: 27341472
    3. we propose that phosphorylation of TOP2A by CDC7/DBF4 in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A function could be relevant to prevent premature separation of centromeric DNA. PMID: 27407105
    4. The anti-invasive and cell cycle arrest-inducing effects of nitrogen-containing bisphosphonates are not DBF4 mediated in human breast cancer cells. PMID: 24287290
    5. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. PMID: 22123827
    6. bipartite interaction between Cdc7 and Dbf4/ASK subunits facilitates ATP binding and substrate recognition by the Cdc7 kinase. PMID: 21536671
    7. Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction PMID: 21036905
    8. Data document the role of DBF4 as a key player in nitrogen-containing bisphosphonate-induced cytotoxicity, thus explaining the effects on the cell-cycle. PMID: 19744312
    9. The interaction with LEDGF relieves autoinhibition of Cdc7-ASK kinase, imposed by the C terminus of ASK. PMID: 19864417
    10. results suggest that E2F regulates the ASK promoter through an atypical mode of recognition of the target site PMID: 12015319
    11. The HuDbf4 gene has of 12 exons over a 33-kb region. The MluI cell-cycle box is needed for core promoter activation. The Sp1 upregulator & HES-1 repressor coordinately determine promoter efficiency. Transcription initiations occur at -220, -235 and -245. PMID: 12420215
    12. Results demonstrate a DNA damage checkpoint that targets Cdc7/Dbf4 protein kinase. PMID: 12535533
    13. Cdc7-Dbf4 kinase efficiently phosphorylates p150. PMID: 16826239
    14. Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. PMID: 16899510
    15. Overexpression of Dbf4 abrogates the S checkpoint response to ultraviolet radiation but not ionizing radiation. PMID: 17276990
    16. There is the differential regulation of a novel gene, namely ASK/Dbf4, in melanoma and suggest that up-regulation of ASK/Dbf4 is a novel molecular determinant with prognostic relevance that confers a proliferative advantage in cutaneous melanoma. PMID: 17768177
    17. Cdc7/Dbf4 kinase activity inhibition affects specific phosphorylation sites on MCM2 in cancer cells PMID: 18286467
    18. ASK/Dbf4, a novel cell survival gene in melanoma is transcriptionally regulated by E2F1. PMID: 18503552
    19. A strong origin of replication at the DBF4 promoter locus, which contains two initiation zones, two origin recognition complex (ORC) binding sites and two DNase I-hypersensitive regions, is identified. PMID: 18536724
    20. increased Cdc7-Dbf4 abundance may be a common occurrence in human malignancies PMID: 18714392
    21. These results indicate that Ddk functions as an upstream regulator to monitor S-phase checkpoint signaling. PMID: 19111665

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
  • 數據庫鏈接:

    HGNC: 17364

    OMIM: 604281

    KEGG: hsa:10926

    STRING: 9606.ENSP00000265728

    UniGene: Hs.485380



主站蜘蛛池模板: 亚洲国产欧美在线人成aaaa| 欧美99久久无码一区人妻a片| 在线观看国产午夜福利片| 高潮迭起av乳颜射后入| 免费人成自慰网站| 亚洲永久网址在线观看| 日韩亚洲中字无码一区二区三区| 高清无码爆乳潮喷在线观看| 野花社区视频www官网| 日本护士毛茸茸高潮| 欧美熟妇与小伙性欧美交| 人摸人人人澡人人超碰97| 国产亚洲产品影市在线产品| 国产午夜伦鲁鲁| 免费全部高h视频无码| 色哟哟最新在线观看入口| 国产又色又爽又高潮免费| 在线 | 一区二区三区| 99日本精品永久免费久久| 亚洲一区二区av在线观看| 中文字幕人乱码中文字幕 | 午夜福利视频合集1000| 国产巨大爆乳在线观看| 免费无码又爽又刺激激情视频软件| 欧美老妇与zozoz0交| 曰本丰满熟妇xxxx性| 亚洲欧美成人久久一区| 无码精品黑人一区二区三区| 色综合久久久久久久久久| 国产成人综合久久精品推最新| 久久久久亚洲精品天堂| 99热在线精品国产观看| 亚洲永久无码7777kkk| 毛色毛片免费观看| 亚洲欧美日韩国产另类电影| 久久精品无码av| 国产对白老熟女正在播放| 久久99精品国产自在现线小黄鸭| 亚洲国产精品无码中文lv| 国产精品人成视频免费999| 国产亚洲精品a在线|