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  4. Cxcl11 Antibody

Cxcl11 Antibody

  • 中文名稱：
    Cxcl11兔多克隆抗體
  • 貨號：
    CSB-PA09289A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA09289A0Rb at dilution of 1:100
  • 其他：

產品詳情

  • 產品描述：

    The rabbit IgG polyclonal antibody was raised against the recombinant C-X-C motif chemokine 11 protein (22-98aa) expressed in mouse. The rabbit anti-serum collected antibody was affinity purified using Protein G, resulting in a purity of over 95%.

    This rabbit anti-mouse Cxcl11 polyclonal antibody is capable of recognizing the mouse Cxcl11 protein and has been validated for use in ELISA and IHC. It can be utilized to detect the presence, quantify the level, or visualize the distribution of Cxcl11 protein in experimental settings.

  • 產品名稱：
    Rabbit anti-Mus musculus (Mouse) Cxcl11 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cxcl11 antibody; Scyb11C-X-C motif chemokine 11 antibody; Interferon-inducible T-cell alpha chemoattractant antibody; I-TAC antibody; Small-inducible cytokine B11 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse C-X-C motif chemokine 11 protein (22-98AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，Cxcl11 Antibody (CSB-PA09289A0Rb)，的標記方式是Non-conjugated。對于Cxcl11 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA09289B0Rb Cxcl11 Antibody, HRP conjugated ELISA
    FITC CSB-PA09289C0Rb Cxcl11 Antibody, FITC conjugated
    Biotin CSB-PA09289D0Rb Cxcl11 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
  • 基因功能參考文獻：
    1. although the expression of CXCL9 and CXCL11 are increased after spinal nerve ligation, they may not contribute to the maintenance of neuropathic pain. PMID: 29712506
    2. These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis PMID: 25713416
    3. very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11. PMID: 24713654
    4. Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process. PMID: 24398292
    5. Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11. PMID: 24566892
    6. Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development. PMID: 22277947
    7. the CXCL11-heparin interaction has two different affinities for glycosaminoglycans PMID: 20363748
    8. I-TAC can have an important role during virus infections and vaccinia virus has evolved ways to avoid inducing I-TAC expression. PMID: 15030574
    9. I-TAC acts as an antagonist for CCR5. I-TAC inhibited the binding of macrophage-inflammatory protein-1alpha (MIP-1alpha)/CC chemokine ligand 3 (CCL3) to cells transfected with CCR5 and to monocytes. PMID: 15178708
    10. Acute ethanol intoxication impairs lung expression of Cxcl11, interfering with pulmonary response to bacterial challenge. PMID: 17889309
    11. homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis PMID: 11500837

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 數據庫鏈接：

    KEGG: mmu:56066

    UniGene: Mm.131723



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