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  4. Cleaved-CTSV (L114) Antibody

Cleaved-CTSV (L114) Antibody

  • 中文名稱：
    Cleaved-CTSV (L114)兔多克隆抗體
  • 貨號：
    CSB-PA000037
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using Cleaved-Cathepsin L2 (L114) Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CAT L2 antibody; Cathepsin L2 antibody; Cathepsin U antibody; Cathepsin V antibody; CathepsinL2 antibody; CathepsinU antibody; CathepsinV antibody; CATL 2 antibody; CATL2 antibody; CATL2_HUMAN antibody; CTS L2 antibody; CTS U antibody; CTS V antibody; CTSL 2 antibody; CTSL2 antibody; CTSU antibody; CTSV antibody; MGC125957 antibody; PRO305 antibody; UNQ268 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Cathepsin L2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cysteine protease. May have an important role in corneal physiology.
  • 基因功能參考文獻：
    1. CTSV is involved in melanosome degradation. PMID: 29654760
    2. exogenous CTSV inhibited Ang -induced hypertrophy in HCM cells by inhibiting PI3K/Akt/mTOR PMID: 28522343
    3. Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors. PMID: 27771373
    4. E2F1 directly binds to CTSL2 promoter and regulates CTSL2 gene expression. PMID: 23542171
    5. using cathepsin V and cathepsin L as model enzymes, a series of chimeras were generated to identify noncatalytic regions that are responsible for the potent elastolytic activity of cathepsin V PMID: 24121514
    6. Cathepsin V expression contributes to the development of dermal fibrosis and vasculopathy in systemic sclerosis. PMID: 23287360
    7. functions of cathepsin V are controlled by N-glycosylation PMID: 22967898
    8. Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases. PMID: 22393040
    9. CTSL2 might be involved in progression of endometrial cancer. PMID: 22452389
    10. A proteolytically active variant of cathepsin V is localized to cell nucleus (in peri-nucleolar pattern) in thyroid carcinoma cells. PMID: 20536394
    11. stratum corneum thiol protease is identical with the recently described cathepsin L2 protease. PMID: 12648222
    12. Cathepsin V is involved in the degradation of invariant chain in human thymus PMID: 12925692
    13. Cathepsin V has an elastolytic activity and is expressed in activated macrophages PMID: 15192101
    14. Human cathepsin V compensates for murine cathepsin L in mouse epidermis and hair follicles. PMID: 15679121
    15. propeptide was found to behave as a tight-binding inhibitor against CatV PMID: 17516850
    16. Associated with type 1 diabetes and early-onset myasthenia gravis. PMID: 17869649
    17. angiogenesis inhibition activity on endothelial cells caused by plasminogen processing by cathepsin V PMID: 18163891

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  • 亞細胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase C1 family
  • 組織特異性：
    Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
  • 數據庫鏈接：

    HGNC: 2538

    OMIM: 603308

    KEGG: hsa:1515

    STRING: 9606.ENSP00000259470

    UniGene: Hs.610096



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