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  4. Cd68 Antibody, FITC conjugated

Cd68 Antibody, FITC conjugated

  • 中文名稱：
    Cd68兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA004951LC01MO
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Mus musculus (Mouse) Cd68 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cd68 antibody; Macrosialin antibody; CD antigen CD68 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Macrosialin protein (21-291AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
  • 基因功能參考文獻：
    1. Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities. PMID: 27869795
    2. Myeloid osteoclast precursors do not express CD68. PMID: 28173622
    3. CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver. PMID: 26216124
    4. Results showed that activated microglia in Alzheimer's disease-like mice showed two-step transition: a CD68-negative activated form at 6-9 months and a CD68-positive form from 12 months of age PMID: 25352454
    5. Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 / CD68 emigration pathway in macrophages PMID: 22163030
    6. These findings demonstrate a role for CD68 in the function of osteoclasts. PMID: 21991369
    7. CD68-null mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4+ T cells, indicating that CD68 may function to negatively regulate antigen uptake, loading, or major histocompatibility complex class II trafficking. PMID: 21572087
    8. Atherogenic diet-induced reduction in lipid levels of Reversa model mouse leads to decreased monocyte-derived CD68-positive cells in advanced atherosclerotic plaques and is associated with emigration of these cells from the atherosclerotic plaques. PMID: 21339485
    9. Macrosialin does not function as an oxLDL receptor on the cell surface. PMID: 12562841
    10. Data show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice. PMID: 16157452

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  • 亞細胞定位：
    [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.; [Isoform Short]: Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    LAMP family
  • 組織特異性：
    Expressed in tissue macrophages and to a lesser extent in dendritic cells.
  • 數據庫鏈接：


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