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CYP4B1 Antibody

  • 中文名稱：
    CYP4B1兔多克隆抗體
  • 貨號：
    CSB-PA006448ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA006448ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA006448ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CYP4B1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CYP4B1
  • 別名：
    CP4B1_HUMAN antibody; CYP4B1 antibody; CYPIVB1 antibody; Cytochrome P450 4B1 antibody; Cytochrome P450 family 4 subfamily B polypeptide 1 antibody; Cytochrome P450 subfamily IVB polypeptide 1 antibody; Cytochrome P450-HP antibody; Microsomal monooxygenase antibody; P450HP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cytochrome P450 4B1 protein (30-250AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
  • 基因功能參考文獻(xiàn)：
    1. the Ser207 insertion does not rescue the P450 functional activity of human CYP4B1 that has been lost during evolution. PMID: 26355749
    2. A proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-ipomeanol bioactivation. PMID: 25247810
    3. polymorphism in humans: evidence for a non-functional allelic variant PMID: 12142726
    4. CYP4B1 is a senescene-associated gene in normal human oral keratinocytes. PMID: 12837283
    5. Results demostrated an increased risk of bladder cancer associated with the CYP4B1*1/*2 and *2/*2 genotypes. PMID: 18713828

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 組織特異性：
    Detected in the liver and lung (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2644

    OMIM: 124075

    KEGG: hsa:1580

    STRING: 9606.ENSP00000360991

    UniGene: Hs.436317



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