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CXXC1 Antibody

  • 中文名稱:
    CXXC1兔多克隆抗體
  • 貨號:
    CSB-PA868380DSR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: CXXC-type zinc finger protein 1 antibody at 2μg/ml
      Lane 1: THP-1 whole cell lysate
      Lane 2: Mouse liver tissue
      Lane 2: Mouse spleen tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 76, 77 kDa
      Observed band size: 76 kDa
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA868380DSR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CXXC1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CXXC1
  • 別名:
    2410002I16Rik antibody; 5830420C16Rik antibody; AI426635 antibody; CFP 1 antibody; CFP1 antibody; CpG binding protein antibody; CpG-binding protein antibody; CXXC 1 antibody; CXXC finger 1 antibody; CXXC finger 1 PHD domain antibody; CXXC finger protein 1 antibody; CXXC type zinc finger protein 1 antibody; CXXC-type zinc finger protein 1 antibody; CXXC1 antibody; CXXC1_HUMAN antibody; DNA binding protein with PHD finger and CXXC domain antibody; hCGBP antibody; HsT2645 antibody; PCCX 1 antibody; PCCX1 antibody; PHD finger and CXXC domain containing protein 1 antibody; PHD finger and CXXC domain-containing protein 1 antibody; PHF 18 antibody; PHF18 antibody; Protein containing CXXC domain 1 antibody; SPP 1 antibody; SPP1 antibody; ZCGPC 1 antibody; ZCGPC1 antibody; Zinc finger; CpG binding type containing 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human CXXC-type zinc finger protein 1 protein (1-210AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
  • 基因功能參考文獻:
    1. CFP1 binds open chromatin regions of active genes, including enhancers and non-CpG islands. PMID: 30292235
    2. directly controls the expression of key genes important for thymocyte survival, such as RORgammat, and for T-cell receptor signaling, including Zap70 and CD8, through maintaining the appropriate H3K4me3 on their promoters PMID: 27210293
    3. NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB and sustained by E2A. PMID: 23851690
    4. The crescent-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA. PMID: 21407193
    5. CXXC finger protein 1 is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex PMID: 16253997
    6. CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line. PMID: 17328666
    7. CGBP interacts with MLL1, MLL2 as well as Set1 H3-Lysine 4 (H3K4) specific methyl-transferases and plays critical roles in regulations of MLL target genes. PMID: 18082152
    8. study shows endogenous DNMT1 & CFP1 interact in vivo; CFP1 interaction with Setd1A or Setd1B not required for its interaction with DNMT1; result indicates CFP1 intersects cytosine methylation machinery independently of its association with Setd1 complexes PMID: 18680430
    9. expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1 PMID: 19433449

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  • 亞細胞定位:
    Nucleus speckle. Nucleus. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 24343

    OMIM: 609150

    KEGG: hsa:30827

    STRING: 9606.ENSP00000390475

    UniGene: Hs.180933



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