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  4. CST7 Antibody

CST7 Antibody

  • 中文名稱：
    CST7兔多克隆抗體
  • 貨號：
    CSB-PA006095ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA006095ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA006095ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CST7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CST7
  • 別名：
    CMAP antibody; CST 7 antibody; Cst7 antibody; Cystatin 7 antibody; cystatin F (leukocystatin) antibody; Cystatin like metastasis associated protein antibody; Cystatin-7 antibody; Cystatin-F antibody; Cystatin-like metastasis-associated protein antibody; Cystatin7 antibody; CystatinF antibody; CYTF_HUMAN antibody; dJ568C11.1 antibody; Leukocystatin antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Cystatin-F protein (20-145AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
  • 基因功能參考文獻：
    1. during monocyte to macrophage differentiation, the endosomal/lysosomal proteolytic activity can be regulated by cystatin F whose expression is under the control of transcriptional factor C/EBP alpha. PMID: 30033148
    2. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells. PMID: 22365146
    3. Transgenic cystatin F is expressed in model mice only during demyelination; in chronic demyelination, remyelinating ability is lost. PMID: 21344476
    4. cystatin F is an intracellular cysteine peptidase inhibitor with readily regulated expression PMID: 12423348
    5. CST7 is secreted, but artificial modification of its C-terminus can induce its endocytic targeting. PMID: 15212960
    6. Cystatin F was not colocalized with cystatin C shich suggests distinct functions for these two cysteine protease inhibitors in U937 cells. PMID: 15752368
    7. analysis of reduction-dependent activation of human cystatin F PMID: 16601115
    8. A latent protease inhibitor which is itself regulated by proteolysis in the endocytic pathway. PMID: 18256700
    9. Data demonstrate the addition of N-linked sugars to an Asn-X-Cys motif in cystatin F and suggest that the mannose 6-phosphate sorting machinery is used to divert cystatin F from the secretory pathway and to mediate its uptake from extracellular pools. PMID: 19192250

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  • 亞細胞定位：
    Secreted. Cytoplasm.
  • 蛋白家族：
    Cystatin family
  • 組織特異性：
    Primarily expressed in peripheral blood cells and spleen.
  • 數據庫鏈接：

    HGNC: 2479

    OMIM: 603253

    KEGG: hsa:8530

    STRING: 9606.ENSP00000420384

    UniGene: Hs.143212



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