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CST1 Antibody

  • 中文名稱:
    CST1兔多克隆抗體
  • 貨號:
    CSB-PA007380
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of Jurkat cells using Cystatin SN Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CST1
  • 別名:
    CST1 antibody; Cystain SAI antibody; Cystain-SA-I antibody; Cystatin 1 antibody; Cystatin-1 antibody; Cystatin-SN antibody; Cystatin1 antibody; Cysteine proteinase inhibitor, type 2 family antibody; CYTN antibody; CYTN_HUMAN antibody; Salivary cystatin SA1 antibody; Salivary cystatin-SA-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Cystatin SN.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
  • 基因功能參考文獻:
    1. Results revealed that CST1 expression was upregulated in colon cancer (CC) compared with normal tissues and contributed to CC cell proliferation. PMID: 29845224
    2. High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer. PMID: 28523467
    3. this results identified cystatin 1 as a biomarker in patients with seasonal allergic rhinitis PMID: 28633877
    4. These results indicate that CST1-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence. PMID: 28383558
    5. interactions of human family 1 & 2 cystatins with cathepsin L1 PMID: 27764212
    6. high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk, and poor survival in patients with surgically resected NSCLCs. PMID: 25648368
    7. In conclusion, our data suggest that CST1 might contribute to the proliferation of pancreatic cancer cells and could be a potential biomarker for the early detection of pancreatic cancer. PMID: 25577248
    8. CST1 may contribute to inactivation of protease allergens and help re-establish homeostasis of the nasal membranes. PMID: 23950865
    9. CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts PMID: 21636832
    10. Murine monoclonal antibodies were made which can distinguish between CST1 and CST2. PMID: 15829315
    11. CST1 might be highly involved in gastric tumorigenesis and regulate the proteolytic activity of cysteine proteases. PMID: 19463800
    12. Identification of Cystatin SN as a novel tumor marker for colorectal cancer. PMID: 19513549

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  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Cystatin family
  • 組織特異性:
    Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.
  • 數據庫鏈接:

    HGNC: 2473

    OMIM: 123855

    KEGG: hsa:1469

    STRING: 9606.ENSP00000305731

    UniGene: Hs.123114



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