在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CRTAM Antibody

CRTAM Antibody

  • 中文名稱：
    CRTAM兔多克隆抗體
  • 貨號(hào)：
    CSB-PA725805
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA725805(CRTAM Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CRTAM; Cytotoxic and regulatory T-cell molecule; Class-I MHC-restricted T-cell-associated molecule; CD antigen CD355
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human CRTAM
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells.
  • 基因功能參考文獻(xiàn)：
    1. These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene. PMID: 26694968
    2. CRTAM is negatively regulated by ZEB1 in T cells. PMID: 25910959
    3. Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 genes. PMID: 23827383
    4. The cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM. PMID: 23871486
    5. The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 on tumor cells. PMID: 23530148
    6. Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level. PMID: 22051697
    7. Results show that CRTAM is a molecule involved in epithelial cell adhesion. PMID: 20556794
    8. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system PMID: 15781451
    9. NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 PMID: 15811952
    10. CRTAM expression is driven by the JNK-AP-1 signaling pathway. PMID: 19695707

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Nectin family
  • 組織特異性：
    In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 T-cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24313

    OMIM: 612597

    KEGG: hsa:56253

    STRING: 9606.ENSP00000227348

    UniGene: Hs.159523



主站蜘蛛池模板： 亚洲欧洲自拍拍偷精品网| 亚洲综合一区二区三区无码 | 亚洲综合国产成人丁香五月激情| 无码精品一区二区三区在线| 日韩成人无码毛片一区二区| 少妇人妻综合久久中文| 亚洲国产综合在线区尤物| 性欧美大战久久久久久久| 国产在线观看码高清视频| www国产亚洲精品久久网站| 无码国产成人午夜电影观看| 亚洲精品无码久久久久秋霞| 粉色午夜视频| 4438xx亚洲最大五色丁香| 亚洲欧美在线人成最新| 国产粉嫩小泬在线观看泬| 久久www免费人成_看片老司机| 免费无码一区二区三区蜜桃| 国产精品沙发午睡系列990531| 在线播放真实国产乱子伦| 女人与公拘交酡全过程| 日韩一区精品视频一区二区| 国产精品久久..4399| 777米奇影视第四色| 热99re久久精品国产首页免费| 三级三级久久三级久久| 国产精品久久久久9999高清| 国产成人精品亚洲午夜麻豆| 国产白浆喷水在线视频| 久久精品人成免费| 午夜福利日本一区二区无码| 精品久久久久中文字幕一区| 久久久天堂国产精品女人| 色欲来吧来吧天天综合网| 成视频年人黄网站免费视频 | 久久久日韩精品一区二区三区| 精品久久久久久国产| 国产精品久久综合免费| 久青草久青草视频在线观看| 国产热の有码热の无码视频| 久久精品国产曰本波多野结衣|