在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Cytotoxic and regulatory T-cell molecule(CRTAM) ELISA kit

  • 中文名稱:
    人細胞毒性和調節性T細胞分子(CRTAM)酶聯免疫試劑盒
  • 貨號:
    CSB-EL005998HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人細胞毒性和調節性T細胞分子(CRTAM)酶聯免疫試劑盒(CSB-EL005998HU)檢測樣本中的CRTAM含量。CRTAM是一個研究靶點。目前其作為免疫球蛋白超家族成員,在淋巴細胞發育、免疫反應調節等方面有重要作用。研究機制主要圍繞其與配體相互作用,調節T細胞活化遷移等,有望為免疫相關疾病治療提供新思路。本產品適用于科研領域,可助力探究CRTAM在免疫細胞激活、細胞間信號傳導及疾病模型中的表達變化與功能機制,為免疫學、腫瘤學等基礎研究提供可靠工具。CRTAM參與細胞間黏附及免疫調控,在炎癥反應、自身免疫性疾病及腫瘤免疫微環境研究中具有重要科研價值。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CRTAM; Cytotoxic and regulatory T-cell molecule; Class-I MHC-restricted T-cell-associated molecule; CD antigen CD355
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 檢測范圍:
    Request Information
  • 靈敏度:
    Request Information
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells.
  • 基因功能參考文獻:
    1. These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene. PMID: 26694968
    2. CRTAM is negatively regulated by ZEB1 in T cells. PMID: 25910959
    3. Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 genes. PMID: 23827383
    4. The cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM. PMID: 23871486
    5. The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 on tumor cells. PMID: 23530148
    6. Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level. PMID: 22051697
    7. Results show that CRTAM is a molecule involved in epithelial cell adhesion. PMID: 20556794
    8. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system PMID: 15781451
    9. NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 PMID: 15811952
    10. CRTAM expression is driven by the JNK-AP-1 signaling pathway. PMID: 19695707

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Nectin family
  • 組織特異性:
    In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 T-cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at
  • 數據庫鏈接:

    HGNC: 24313

    OMIM: 612597

    KEGG: hsa:56253

    STRING: 9606.ENSP00000227348

    UniGene: Hs.159523



主站蜘蛛池模板: 亚洲国产制服丝袜高清在线| 亚洲不乱码卡一卡二卡4卡5| 成 人 黄 色 大片| 成 人 网 站不卡在线观看| 色一情一乱一乱一区99av白浆| 精品人妻中文无码av在线| 人妻丰满熟妇无码区免费| 中文无码伦av中文字幕在线| 欧美成人午夜免费影院手机在线看 | 亚洲精品国产嫩草在线观看东京热| 一色屋精品视频在线观看免费| 日韩v亚洲v欧美v精品综合| 国模小黎自慰gogo人体| 日日噜噜夜夜狠狠久久蜜桃| 亚洲aⅴ在线无码播放毛片一线天| 麻豆精品国产熟妇aⅴ一区| 无码人妻av一区二区三区蜜臀| 精品国际久久久久999| av区无码字幕中文色| 少妇裸体性生交| 国产午夜精品无码| 一区二区三区高清日本vr| 在线视+欧美+亚洲日本| 无码熟妇αⅴ人妻又粗又大| 成a人片亚洲日本久久| 欧美成 人影片 aⅴ免费观看| 国产亚洲欧美日韩俺去了| 欧美刺激性大交| 亚洲精品1卡2卡三卡4卡乱码| 中文字幕av无码免费一区| 精品国内在视频线2019| 97国产精东麻豆人妻电影 | 九九综合九色综合网站| 国产八十老太另类| 精品香蕉99久久久久网站| 少妇粉嫩小泬喷水视频| 久热在线这里只有精品国产| 午夜影视免费x看| 麻豆亚洲一区| 亚洲综合小说专区图片| 欧美另类 自拍 亚洲 图区|