在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Cytotoxic and regulatory T-cell molecule(CRTAM) ELISA kit

  • 中文名稱:
    人細胞毒性和調節性T細胞分子(CRTAM)酶聯免疫試劑盒
  • 貨號:
    CSB-EL005998HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人細胞毒性和調節性T細胞分子(CRTAM)酶聯免疫試劑盒(CSB-EL005998HU)檢測樣本中的CRTAM含量。CRTAM是一個研究靶點。目前其作為免疫球蛋白超家族成員,在淋巴細胞發育、免疫反應調節等方面有重要作用。研究機制主要圍繞其與配體相互作用,調節T細胞活化遷移等,有望為免疫相關疾病治療提供新思路。本產品適用于科研領域,可助力探究CRTAM在免疫細胞激活、細胞間信號傳導及疾病模型中的表達變化與功能機制,為免疫學、腫瘤學等基礎研究提供可靠工具。CRTAM參與細胞間黏附及免疫調控,在炎癥反應、自身免疫性疾病及腫瘤免疫微環境研究中具有重要科研價值。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CRTAM; Cytotoxic and regulatory T-cell molecule; Class-I MHC-restricted T-cell-associated molecule; CD antigen CD355
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 檢測范圍:
    Request Information
  • 靈敏度:
    Request Information
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells.
  • 基因功能參考文獻:
    1. These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene. PMID: 26694968
    2. CRTAM is negatively regulated by ZEB1 in T cells. PMID: 25910959
    3. Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 genes. PMID: 23827383
    4. The cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM. PMID: 23871486
    5. The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 on tumor cells. PMID: 23530148
    6. Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level. PMID: 22051697
    7. Results show that CRTAM is a molecule involved in epithelial cell adhesion. PMID: 20556794
    8. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system PMID: 15781451
    9. NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 PMID: 15811952
    10. CRTAM expression is driven by the JNK-AP-1 signaling pathway. PMID: 19695707

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Nectin family
  • 組織特異性:
    In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 T-cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at
  • 數據庫鏈接:

    HGNC: 24313

    OMIM: 612597

    KEGG: hsa:56253

    STRING: 9606.ENSP00000227348

    UniGene: Hs.159523



主站蜘蛛池模板: 18禁成年无码免费网站| 播五月开心婷婷欧美综合| 亚洲成av大片大片在线播放| 白嫩少妇bbw撒尿视频| 无码一区二区三区在线| 四虎影视成人永久免费观看视频| 国产欧美日韩一区2区| 午夜视频在线观看免费完整版 | 亚洲欧美成人一区二区在线电影| 乱子伦一区二区三区| 国产亚洲精品久久久久5区| 国产综合视频一区二区三区| 亚洲精品中文字幕一区二区三区 | 影音先锋无码aⅴ男人资源站| 亚洲精品久久国产高清情趣图文 | 欧性猛交ⅹxxx乱大交| 日韩精品真人荷官无码| 一本大道大臿蕉视频无码| 国产网红无码精品视频| 色综合色狠狠天天综合色| 国产成人8x人网站视频| 久久九九国产精品怡红院| 国产999精品成人网站| 久久香蕉国产线看观看怡红院妓院 | 午夜在线a亚洲v天堂网2018| 久久国产欧美成人网站| av免费网站在线观看| 久久国产劲爆∧v内射-百度| www激情内射在线看| 在线天堂资源www中文| 中国女人做爰视频| 狠狠色噜噜狼狼狼色综合久| 亚洲精品久久久无码大桥未久| 香蕉久久精品日日躁夜夜躁夏| 好男人社区资源| 人妻一区二区三区高清av专区| 久久精品亚洲中文字幕无码麻豆| 亚洲va久久久噜噜噜久久| 国产揉捏爆乳巨胸挤奶视频| 午夜爱爱爱爱爽爽爽网站 | 婷婷亚洲久悠悠色悠在线播放|