在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Cytotoxic and regulatory T-cell molecule(CRTAM) ELISA kit

  • 中文名稱:
    人細胞毒性和調節性T細胞分子(CRTAM)酶聯免疫試劑盒
  • 貨號:
    CSB-EL005998HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人細胞毒性和調節性T細胞分子(CRTAM)酶聯免疫試劑盒(CSB-EL005998HU)檢測樣本中的CRTAM含量。CRTAM是一個研究靶點。目前其作為免疫球蛋白超家族成員,在淋巴細胞發育、免疫反應調節等方面有重要作用。研究機制主要圍繞其與配體相互作用,調節T細胞活化遷移等,有望為免疫相關疾病治療提供新思路。本產品適用于科研領域,可助力探究CRTAM在免疫細胞激活、細胞間信號傳導及疾病模型中的表達變化與功能機制,為免疫學、腫瘤學等基礎研究提供可靠工具。CRTAM參與細胞間黏附及免疫調控,在炎癥反應、自身免疫性疾病及腫瘤免疫微環境研究中具有重要科研價值。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CRTAM; Cytotoxic and regulatory T-cell molecule; Class-I MHC-restricted T-cell-associated molecule; CD antigen CD355
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 檢測范圍:
    Request Information
  • 靈敏度:
    Request Information
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells.
  • 基因功能參考文獻:
    1. These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene. PMID: 26694968
    2. CRTAM is negatively regulated by ZEB1 in T cells. PMID: 25910959
    3. Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 genes. PMID: 23827383
    4. The cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM. PMID: 23871486
    5. The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 on tumor cells. PMID: 23530148
    6. Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level. PMID: 22051697
    7. Results show that CRTAM is a molecule involved in epithelial cell adhesion. PMID: 20556794
    8. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system PMID: 15781451
    9. NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 PMID: 15811952
    10. CRTAM expression is driven by the JNK-AP-1 signaling pathway. PMID: 19695707

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Nectin family
  • 組織特異性:
    In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 T-cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at
  • 數據庫鏈接:

    HGNC: 24313

    OMIM: 612597

    KEGG: hsa:56253

    STRING: 9606.ENSP00000227348

    UniGene: Hs.159523



主站蜘蛛池模板: 欧美精品一产区二产区| 狠狠色丁香婷婷综合尤物| 青青草国产午夜精品| 2020精品自拍视频曝光| 精品国内综合一区二区| 亚洲人成黄网站69影院| 国产亚洲精品俞拍视频| 无码人妻精品一区二区三区东京热| 日本一道综合久久aⅴ久久| 丁香五月综合久久激情| 亚洲va欧美va国产va综合| 夜夜躁很很躁日日躁麻豆| 天堂а√在线中文在线| 日产幕无线码三区在线| 欧美孕妇xxxx做受欧美88| 99久re热视频这里只有精品6| 好大好硬好爽免费视频| 欧美三根一起进三p| 久久久久久a亚洲欧洲av| a 'v片欧美日韩在线| 欧美性大战xxxxx久久久√| 日韩激情无码不卡码| 国产suv精品一区二区6| 亚洲精品宾馆在线精品酒店| 中文字幕制服丝袜第57页| 久久综合久色欧美综合狠狠| 人妻另类 专区 欧美 制服| 亚洲国产成人超a在线播放| 国产精品久久久久影院色| 亚洲精品国产一区二区精华液| 国产精品亚洲片在线观看不卡| 国产一区二区亚洲精品 | 亚洲熟妇国产熟妇肥婆| 中文无码字幕中文有码字幕| 国产精品亚洲二区在线看| 欧美极品少妇×xxxbbb| 国产99久一区二区三区a片| 国产高清精品软件丝瓜软件| 日本中文一区二区三区亚洲| 国产免费内射又粗又爽密桃视频| 欧美成人h亚洲综合在线观看|