在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CRB2 Antibody, HRP conjugated

  • 中文名稱:
    CRB2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA692212LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CRB2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Crb2 antibody; CRUM2_HUMAN antibody; Crumbs homolog 2 (Drosophila) antibody; Crumbs homolog 2 antibody; Crumbs-like protein 2 antibody; RP11-230L22.2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein crumbs homolog 2 protein (253-483AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness. May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells. Also required for maintenance of the apical polarity complex during development of the cortex. Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription.
  • 基因功能參考文獻:
    1. Case Report: steroid-resistant nephrotic syndrome caused by a novel Crumbs homolog 2 mutation. PMID: 29473663
    2. These findings demonstrate that Crb2 abnormalities caused by these mutations are the mechanism of steroid-resistant nephrotic syndrome PMID: 27942854
    3. Clinically, CRB2 should be assessed when ciliopathy is suspected, especially in Ashkenazi Jews, where we found that p.N800K carrier frequency is 1 of 64. Patients harboring CRB2 mutations should be tested for the complete range of ciliopathy manifestations. PMID: 26925547
    4. Additional sequence variants in genes involved in kidney development were found in patients with CRB2-related syndrome, suggesting that these variants may modify the phenotype. PMID: 27004616
    5. We demonstrate that CRB2 mutations result in loss of function and therefore constitute causative mutations leading to Nephrotic syndrome in humans. PMID: 25557779
    6. The three families with six affected individuals present compelling evidence for the role of CRB2 in human disease, with a phenotype comprising severe, congenital neurological and renal involvement. PMID: 25557780
    7. Study showed that CRB1 and CRB2 in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 influences the severity of the murine Crb1-linked retinal dystrophies. PMID: 24565864
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 20583170
    9. results suggest that CRB2 functions as an inhibitory binding protein that is involved in the formation of a mature but inactive pool of the gamma-secretase complex PMID: 20299451
    10. Crumbs homolog 2 gene maps to human chromosome 9q33.3 PMID: 14767562
    11. This study shows that CRB2 sequence variants are not a common cause of autosomal recessive RP and LCA. PMID: 15851977
    12. Using X-ray crystallography and NMR spectroscopy, we show that, despite low amino acid sequence conservation, both 53BP1 and Crb2 contain tandem tudor domains that interact with histone H4 specifically dimethylated at Lys20 (H4-K20me2). PMID: 17190600
    13. overexpression of human CRB1 and related isoforms, CRB2 and CRB3, had no effect on the levels of presenilin complex components, on NCT maturation or on PS endoproteolysis PMID: 17988153
    14. The CRB2 gene encodes a transmembrane protein (1285 aa) and a secreted protein (1176 aa). The transmembrane isoform consists of 14 extracellular EGF-like domains, 3 extracellular laminin G-like domains, and a Crb cytoplasmic tail domain. PMID: 14767562

    顯示更多

    收起更多

  • 相關疾病:
    Focal segmental glomerulosclerosis 9 (FSGS9); Ventriculomegaly with cystic kidney disease (VMCKD)
  • 亞細胞定位:
    [Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell junction.; [Isoform 2]: Secreted.
  • 蛋白家族:
    Crumbs protein family
  • 組織特異性:
    Expressed in glomeruli, podocytes of the glomerular capillary loops, and parietal glomerular epithelial cells in the kidney (at protein level). Expressed in retina, fetal eye and brain. Also expressed in kidney, RPE/choroid, and at low levels in lung, pla
  • 數據庫鏈接:

    HGNC: 18688

    OMIM: 219730

    KEGG: hsa:286204

    STRING: 9606.ENSP00000362734

    UniGene: Hs.568340



主站蜘蛛池模板: 亚洲熟妇丰满xxxxx| 影音先锋人妻av中文字幕久久 | 亚洲成av人片天堂网站| 第九色区av天堂| 国产精品多人p群无码| 2019久久视频这里有精品15| 国产成人午夜精品影院| 亚洲中文字幕无码中文字| 98国产精品综合一区二区三区| 国产日韩制服丝袜第一页| 把腿张开老子臊烂你多p视频| 国产成人亚洲综合| 亚洲色欲久久久久综合网| 玩弄了裸睡少妇人妻野战| 国产免费网站看v片在线无遮挡| 成人精品一区日本无码网| 国产色产综合色产在线视频 | 亚洲 卡通 欧美 制服 中文| 欧美噜噜久久久xxx| 美女张开腿让男人桶爽| 午夜好爽好舒服免费视频| 97免费人妻在线视频| 精品国精品国产自在久国产应用| 亚洲精品美女久久久久99| 国内精品乱码卡一卡2卡| 久久国产精品无码网站| 亚洲色婷婷久久精品av蜜桃| 久久精品国产第一区二区三区| 天天影视性色香欲综合网| 成年美女黄网站色大片免费看 | 欧美 国产 日产 韩国 在线| 丝袜熟女国偷自产中文字幕亚洲| 中文字幕av无码一区二区三区电影| 成人区人妻精品一区二区不卡视频 | 中文字幕人妻偷伦在线视频| 成年美女黄网站色奶头大全| 亚洲精品亚洲人成在线观看| 少妇无码精油按摩专区| 国产丰满老熟妇乱xxx1区| 成av人片在线观看www| 国产 成人 综合 亚洲 网站|