在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CRB2 Antibody, FITC conjugated

  • 中文名稱:
    CRB2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA692212LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CRB2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Crb2 antibody; CRUM2_HUMAN antibody; Crumbs homolog 2 (Drosophila) antibody; Crumbs homolog 2 antibody; Crumbs-like protein 2 antibody; RP11-230L22.2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein crumbs homolog 2 protein (253-483AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness. May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells. Also required for maintenance of the apical polarity complex during development of the cortex. Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription.
  • 基因功能參考文獻:
    1. Case Report: steroid-resistant nephrotic syndrome caused by a novel Crumbs homolog 2 mutation. PMID: 29473663
    2. These findings demonstrate that Crb2 abnormalities caused by these mutations are the mechanism of steroid-resistant nephrotic syndrome PMID: 27942854
    3. Clinically, CRB2 should be assessed when ciliopathy is suspected, especially in Ashkenazi Jews, where we found that p.N800K carrier frequency is 1 of 64. Patients harboring CRB2 mutations should be tested for the complete range of ciliopathy manifestations. PMID: 26925547
    4. Additional sequence variants in genes involved in kidney development were found in patients with CRB2-related syndrome, suggesting that these variants may modify the phenotype. PMID: 27004616
    5. We demonstrate that CRB2 mutations result in loss of function and therefore constitute causative mutations leading to Nephrotic syndrome in humans. PMID: 25557779
    6. The three families with six affected individuals present compelling evidence for the role of CRB2 in human disease, with a phenotype comprising severe, congenital neurological and renal involvement. PMID: 25557780
    7. Study showed that CRB1 and CRB2 in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 influences the severity of the murine Crb1-linked retinal dystrophies. PMID: 24565864
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 20583170
    9. results suggest that CRB2 functions as an inhibitory binding protein that is involved in the formation of a mature but inactive pool of the gamma-secretase complex PMID: 20299451
    10. Crumbs homolog 2 gene maps to human chromosome 9q33.3 PMID: 14767562
    11. This study shows that CRB2 sequence variants are not a common cause of autosomal recessive RP and LCA. PMID: 15851977
    12. Using X-ray crystallography and NMR spectroscopy, we show that, despite low amino acid sequence conservation, both 53BP1 and Crb2 contain tandem tudor domains that interact with histone H4 specifically dimethylated at Lys20 (H4-K20me2). PMID: 17190600
    13. overexpression of human CRB1 and related isoforms, CRB2 and CRB3, had no effect on the levels of presenilin complex components, on NCT maturation or on PS endoproteolysis PMID: 17988153
    14. The CRB2 gene encodes a transmembrane protein (1285 aa) and a secreted protein (1176 aa). The transmembrane isoform consists of 14 extracellular EGF-like domains, 3 extracellular laminin G-like domains, and a Crb cytoplasmic tail domain. PMID: 14767562

    顯示更多

    收起更多

  • 相關疾病:
    Focal segmental glomerulosclerosis 9 (FSGS9); Ventriculomegaly with cystic kidney disease (VMCKD)
  • 亞細胞定位:
    [Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell junction.; [Isoform 2]: Secreted.
  • 蛋白家族:
    Crumbs protein family
  • 組織特異性:
    Expressed in glomeruli, podocytes of the glomerular capillary loops, and parietal glomerular epithelial cells in the kidney (at protein level). Expressed in retina, fetal eye and brain. Also expressed in kidney, RPE/choroid, and at low levels in lung, pla
  • 數據庫鏈接:

    HGNC: 18688

    OMIM: 219730

    KEGG: hsa:286204

    STRING: 9606.ENSP00000362734

    UniGene: Hs.568340



主站蜘蛛池模板: av中文字幕无码免费看| 久久天天躁狠狠躁夜夜2020一| 日韩人妻一区二区三区蜜桃视频| 蜜芽久久人人超碰爱香蕉| 欧美乱码精品一区二区三区| 亚洲性视频免费视频网站| 亚洲最新无码成av人| 亚洲色欲在线播放一区| 6080亚洲人久久精品| 亚洲色一区二区三区四区| 人人做人人爽人人爱| 国产区精品系列在线观看| 免费看撕开奶罩揉吮奶头视频| 玩50岁四川熟女大白屁股直播| 亚洲第一页综合图片自拍| 亚洲中文无码永久免费| 免费男人下部进女人下部视频| 亚洲乱码卡一卡二卡| 亚洲伦无码中文字幕另类| 永久免费无码av网站在线观看| 久久这里只精品国产免费10| 日本不卡不码高清视频| 国产99视频精品免费视频6| 亚洲熟女综合色一区二区三区| 亚洲精品蜜夜内射| 天天爽夜夜爽夜夜爽| 人人澡人人曰人人摸看| 狠狠亚洲狠狠欧洲2019| 黑人巨茎美女高潮视频| 色狠狠一区二区三区香蕉| 亚洲人禽杂交av片久久| 免费看又色又爽又黄的国产软件| 亚洲精品成人区在线观看| 另类老妇奶性生bbwbbw | 青青草原精品资源站久久| 福利cosplayh裸体の福利| 久久久久久国产精品免费免费男同 | 国产区精品系列在线观看| 国产精品久人妻精品老妇| 日韩在线不卡免费视频一区| 97久久综合区小说区图片区|