在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CPSF4 Antibody

CPSF4 Antibody

  • 中文名稱：
    CPSF4兔多克隆抗體
  • 貨號：
    CSB-PA913267
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, 293T cells, Primary antibody: CSB-PA913267(CPSF4 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CPSF4
  • 別名：
    cleavage and polyadenylation specific factor 4; 30kDa antibody; Cleavage and polyadenylation specificity factor 30 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 4 antibody; cleavage polyadenylation specificity factor; 30kD antibody; CPSF 30 kDa subunit antibody; CPSF30 antibody; Cpsf4 antibody; CPSF4_HUMAN antibody; NAR antibody; Neb-1 antibody; NEB1 antibody; No arches homolog antibody; no arches like zinc finger protein antibody; NS1 effector domain binding protein 1 antibody; NS1 effector domain-binding protein 1 antibody; OTTHUMP00000206235 antibody; OTTHUMP00000206237 antibody; OTTHUMP00000206239 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CPSF4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
  • 基因功能參考文獻(xiàn)：
    1. The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation. PMID: 29274231
    2. Residues F103 and M106 within the NS1-CPSF4 binding region are important for viral replication. PMID: 28554059
    3. Cleavage and polyadenylation specific factor 4 targets NF-kappaB/cyclooxygenase-2 signaling to promote the growth and survival of non-small cell lung carcinoma cells. PMID: 27450326
    4. These findings support a role for iron in some zinc-finger proteins. Using electrophoretic mobility shift assays and fluorescence anisotropy, we report that CPSF30 selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF30/RNA binding. PMID: 27071088
    5. unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA PMID: 25301780
    6. CPSF4 upregulates human TERT promoter activity, human TERT expression and telomerase activity. PMID: 24618080
    7. Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A). PMID: 24562912
    8. CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma. PMID: 24358221
    9. Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding. PMID: 17522219

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    CPSF4/YTH1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2327

    OMIM: 603052

    KEGG: hsa:10898

    STRING: 9606.ENSP00000292476

    UniGene: Hs.489287



主站蜘蛛池模板： 欧美日韩无线码在线观看| 日本va在线视频播放| 成人乱码一区二区三区av| 天堂www中文在线资源| 国产精品99久久免费黑人人妻| 风流少妇按摩来高潮| 一本一道vs无码中文字幕| 亚洲最大成人综合网720p| 天堂а√在线最新版中文| 日产精品卡2卡三卡乱码网站| 久久精品www人人做人人爽| 国产末成年女av片一区二区| 5d肉蒲团之性战奶水| 疯狂撞击丝袜人妻| 久久亚洲精品成人av无码网站| 人人妻人人澡人人爽人人精品97| 玩弄丰满熟妇xxxxx性60| 亚洲中文在线精品国产| 后入到高潮免费观看| 女人爽到高潮免费看视频| 国产性猛交╳xxx乱大交 | 超碰97人人射妻| 中文字幕人妻熟女人妻洋洋| 国产成人亚洲高清一区| 在线精品视频一区二区三四| 露脸内射熟女--69xx| 内射后入在线观看一区| 国产精品爆乳在线播放第一人称| 欧美毛多水多黑寡妇| 国产 日韩 欧美 视频 制服| 人妻av无码中文专区久久 | 野外做受又硬又粗又大视频| 欧美性猛交xxxx乱大交丰满| 日韩人妻潮喷中文在线视频| 婷婷五月综合色中文字幕| 熟妇人妻系列av无码一区二区| 久久久久人妻精品一区蜜桃| 亚洲精品久久久久久久观小说| 亚洲欧美成αⅴ人在线观看| 日韩人妻无码精品-专区| 成年无码av片|