在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CPSF4 Antibody

CPSF4 Antibody

  • 中文名稱：
    CPSF4兔多克隆抗體
  • 貨號：
    CSB-PA282084
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA282084(CPSF4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA282084(CPSF4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CPSF4
  • 別名：
    cleavage and polyadenylation specific factor 4; 30kDa antibody; Cleavage and polyadenylation specificity factor 30 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 4 antibody; cleavage polyadenylation specificity factor; 30kD antibody; CPSF 30 kDa subunit antibody; CPSF30 antibody; Cpsf4 antibody; CPSF4_HUMAN antibody; NAR antibody; Neb-1 antibody; NEB1 antibody; No arches homolog antibody; no arches like zinc finger protein antibody; NS1 effector domain binding protein 1 antibody; NS1 effector domain-binding protein 1 antibody; OTTHUMP00000206235 antibody; OTTHUMP00000206237 antibody; OTTHUMP00000206239 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CPSF4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
  • 基因功能參考文獻：
    1. The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation. PMID: 29274231
    2. Residues F103 and M106 within the NS1-CPSF4 binding region are important for viral replication. PMID: 28554059
    3. Cleavage and polyadenylation specific factor 4 targets NF-kappaB/cyclooxygenase-2 signaling to promote the growth and survival of non-small cell lung carcinoma cells. PMID: 27450326
    4. These findings support a role for iron in some zinc-finger proteins. Using electrophoretic mobility shift assays and fluorescence anisotropy, we report that CPSF30 selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF30/RNA binding. PMID: 27071088
    5. unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA PMID: 25301780
    6. CPSF4 upregulates human TERT promoter activity, human TERT expression and telomerase activity. PMID: 24618080
    7. Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A). PMID: 24562912
    8. CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma. PMID: 24358221
    9. Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding. PMID: 17522219

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    CPSF4/YTH1 family
  • 數據庫鏈接：

    HGNC: 2327

    OMIM: 603052

    KEGG: hsa:10898

    STRING: 9606.ENSP00000292476

    UniGene: Hs.489287



主站蜘蛛池模板： 一卡二卡3卡4卡视频免费播放| 一道久久爱综合久久爱| 性色做爰片在线观看ww | 亚洲精品少妇高清30p| 国产交换配偶在线视频| 日日噜噜大屁股熟妇| 国产成人免费高清直播| 亚洲中文字幕aⅴ天堂| 人妻体内射精一区二区三四| 中文字幕日韩一区二区三区不卡| 中文字幕丰满乱孑伦无码专区| 日日噜噜夜夜狠狠久久丁香五月| а√天堂www在线а√天堂视频| 国产欧色美视频综合二区| 成人国产一区二区精品小说| 熟女少妇丰满一区二区| 隔壁邻居是巨爆乳寡妇| 97影院理论片手机在线观看| 午夜免费国产体验区免费的| 国产精品亚洲а∨怡红院| 成人亚洲a片v一区二区三区动漫| 99久久久无码国产精品免费砚床| 粗大的内捧猛烈进出| 无码少妇精品一区二区免费| 欧美96在线 | 欧| 欧美日韩国产亚洲沙发| 少妇人妻综合久久中文| 日本免费一区二区三区| 无套内内射视频网站| 中文字幕在线免费看线人| 久久婷婷五月综合97色直播 | 中文字幕av在线一二三区| 中文字幕人妻a片免费看| 亚洲v国产v天堂a无码二区| 日本xxxxx片免费观看喷水| 又色又爽又黄的视频网站| 亚洲中文字幕无码爆乳app| 国产精品国产三级国av麻豆| 国产精品美女久久久m| 国产aⅴ夜夜欢一区二区三区| 免费无码一区二区三区a片百度|