在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. COX4I1 Antibody

COX4I1 Antibody

  • 中文名稱：
    COX4I1兔多克隆抗體
  • 貨號：
    CSB-PA246804
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA246804(COX4I1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA246804(COX4I1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AL024441 antibody; COX 4 antibody; COX IV 1 antibody; COX IV antibody; COX IV-1 antibody; Cox4 antibody; COX41_HUMAN antibody; Cox4a antibody; COX4B antibody; COX4I1 antibody; COX4I2 antibody; COX4L2 antibody; COXIV antibody; Cytochrome c oxidase polypeptide IV antibody; Cytochrome c oxidase subunit 4 isoform 1 mitochondrial antibody; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial antibody; Cytochrome C Oxidase subunit IV antibody; Cytochrome c oxidase subunit IV isoform 1 antibody; Cytochrome c oxidase subunit IV isoform 2 (lung) antibody; Cytochrome c oxydase subunit 4 antibody; dJ857M17.2 antibody; MGC105470 antibody; MGC72016 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human COX4I1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:20-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能參考文獻：
    1. In case of myocardial insufficiency and dilated cardiomyopathy, decreased expression of COX 4 results in an impaired CytOx activity. Higher enzymatic activity but equal oxygen consumption contribute to the pathophysiology of the myocardial insufficiency and appears as an indicator of oxidative stress. This kind of dysregulation should be in the focus for the development of diagnostic and therapy procedures PMID: 30223867
    2. COX4I1 variant K101N was identified in a patient with short stature, poor weight gain and increased chromosomal breaks, simulating Fanconi anemia. PMID: 28766551
    3. This cohort study showed that the COX411 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID: 28916538
    4. We provide evidence that COX4-1 controls BMI1 expression via a redox mechanism PMID: 25726526
    5. COXIV mRNA (1.6 fold; P<0.01) and COXIV protein expression (1.5 fold; P<0.05) were increased by training but COXIV protein expression was decreased (20%; P<0.01) by acute exercise pre- and post-training. PMID: 23285255
    6. COX activity (electron transport complex IV) is reduced by 29% in maternal history of Alzheimer's disease compared to normal controls, and by 30% compared to paternal history of Alzheimer's disease. PMID: 21841246
    7. Studies suggest a model that links cell signaling with the phosphorylation state of Cytochrome c (Cytc) and cytochrome c oxidase (COX). PMID: 21771582
    8. Studies suggest that the main function of nuclear encoded subunits of cytochrome c oxidase appears to be "only" to control the activity of the mitochondrial subunits. PMID: 21802404
    9. Studies indicate that the mechanism for proton pumping in cytochrome c oxidase is based on an electrostatic analysis of a kinetic experiment for the O to E transition. PMID: 21978537
    10. Studies indicate that nitric oxide (NO) inhibition of cytochrome c oxidase (CcOX) is rapid and reversible and may occur in competition with oxygen. PMID: 21939634
    11. Studies indicate that the cytochrome oxidase enzyme-substrate (ES) Michaelis complex of cell respiration, the dioxygen adduct of heme a(3), which he termed Compound A. PMID: 22079200
    12. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4 PMID: 20307258
    13. Data found that subunits Cox6a, Cox6b and Cox7a assembled into pre-existing complex IV, while Cox4-1 and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates. PMID: 19843159
    14. study points to a role for surfeit 1(SURF1) in promoting the association of cytochrome c oxidase II with the cytochrome c oxidase I.cytochrome c oxidase subunit 4.cytochrome c oxidase subunit 5A subassembly PMID: 14607829
    15. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation. PMID: 17418790

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase IV family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 2265

    OMIM: 123864

    KEGG: hsa:1327

    STRING: 9606.ENSP00000253452

    UniGene: Hs.433419



主站蜘蛛池模板： 97一区二区国产好的精华液| 国产女主播白浆在线观看| 亚洲综合最新无码专区| 亚洲精品天堂成人片av在线播放| 国产成人av在线播放影院| 日韩va中文字幕无码电影| 久青草久青草视频在线观看| 国产精品国产三级欧美二区| 亚洲vs成人无码人在线观看堂| 正在播放酒店约少妇高潮| 熟女无套内射线观56| 国产熟妇按摩3p高潮大叫| 日本亲子乱子伦xxxx50路| 狠狠狠狼鲁亚洲综合网| 少妇被多人c夜夜爽爽| 毛片免费观看天天干天天爽| 无码av大香线蕉| 少妇高潮av久久久久久| 美女黄网站18禁免费看| 饥渴少妇av无码影片| 自愉自愉产区二十四区| 日本无遮挡吸乳视频| 内射一区二区精品视频在线观看| 天堂资源中文最新版在线一区| 少妇特黄a一区二区三区| 久久成人国产精品| 人人爽久久久噜人人看| 亚洲综合色婷婷七月丁香| 无码人妻精品中文字幕| 国产良妇出轨视频在线观看| 2021无码最新国产在线观看| 国产成人精品av| 国产丝袜肉丝视频在线| 天天狠天天透天干天干| 热re99久久精品国产66热| 中文字幕亚洲无线码| 少妇高潮大叫好爽| 18禁无遮挡羞羞污污污污网站 | 浮妇高潮喷白浆视频| 在线观看免费人成视频色9| 欧美大荫蒂毛茸茸视频|