在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. COX4I1 Antibody

COX4I1 Antibody

  • 中文名稱：
    COX4I1兔多克隆抗體
  • 貨號：
    CSB-PA001765
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of A549 cells using COX4 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AL024441 antibody; COX 4 antibody; COX IV 1 antibody; COX IV antibody; COX IV-1 antibody; Cox4 antibody; COX41_HUMAN antibody; Cox4a antibody; COX4B antibody; COX4I1 antibody; COX4I2 antibody; COX4L2 antibody; COXIV antibody; Cytochrome c oxidase polypeptide IV antibody; Cytochrome c oxidase subunit 4 isoform 1 mitochondrial antibody; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial antibody; Cytochrome C Oxidase subunit IV antibody; Cytochrome c oxidase subunit IV isoform 1 antibody; Cytochrome c oxidase subunit IV isoform 2 (lung) antibody; Cytochrome c oxydase subunit 4 antibody; dJ857M17.2 antibody; MGC105470 antibody; MGC72016 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human COX4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能參考文獻：
    1. In case of myocardial insufficiency and dilated cardiomyopathy, decreased expression of COX 4 results in an impaired CytOx activity. Higher enzymatic activity but equal oxygen consumption contribute to the pathophysiology of the myocardial insufficiency and appears as an indicator of oxidative stress. This kind of dysregulation should be in the focus for the development of diagnostic and therapy procedures PMID: 30223867
    2. COX4I1 variant K101N was identified in a patient with short stature, poor weight gain and increased chromosomal breaks, simulating Fanconi anemia. PMID: 28766551
    3. This cohort study showed that the COX411 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID: 28916538
    4. We provide evidence that COX4-1 controls BMI1 expression via a redox mechanism PMID: 25726526
    5. COXIV mRNA (1.6 fold; P<0.01) and COXIV protein expression (1.5 fold; P<0.05) were increased by training but COXIV protein expression was decreased (20%; P<0.01) by acute exercise pre- and post-training. PMID: 23285255
    6. COX activity (electron transport complex IV) is reduced by 29% in maternal history of Alzheimer's disease compared to normal controls, and by 30% compared to paternal history of Alzheimer's disease. PMID: 21841246
    7. Studies suggest a model that links cell signaling with the phosphorylation state of Cytochrome c (Cytc) and cytochrome c oxidase (COX). PMID: 21771582
    8. Studies suggest that the main function of nuclear encoded subunits of cytochrome c oxidase appears to be "only" to control the activity of the mitochondrial subunits. PMID: 21802404
    9. Studies indicate that the mechanism for proton pumping in cytochrome c oxidase is based on an electrostatic analysis of a kinetic experiment for the O to E transition. PMID: 21978537
    10. Studies indicate that nitric oxide (NO) inhibition of cytochrome c oxidase (CcOX) is rapid and reversible and may occur in competition with oxygen. PMID: 21939634
    11. Studies indicate that the cytochrome oxidase enzyme-substrate (ES) Michaelis complex of cell respiration, the dioxygen adduct of heme a(3), which he termed Compound A. PMID: 22079200
    12. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4 PMID: 20307258
    13. Data found that subunits Cox6a, Cox6b and Cox7a assembled into pre-existing complex IV, while Cox4-1 and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates. PMID: 19843159
    14. study points to a role for surfeit 1(SURF1) in promoting the association of cytochrome c oxidase II with the cytochrome c oxidase I.cytochrome c oxidase subunit 4.cytochrome c oxidase subunit 5A subassembly PMID: 14607829
    15. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation. PMID: 17418790

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase IV family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 2265

    OMIM: 123864

    KEGG: hsa:1327

    STRING: 9606.ENSP00000253452

    UniGene: Hs.433419



主站蜘蛛池模板： 少妇性l交大片7724com| 天天爽天天狠久久久综合麻豆 | 好爽别插了无码视频| 精品久久久久久无码国产| 亚洲电影天堂av2017 | 国产放荡对白视频在线观看| 亚洲无人区一区二区三区| 欧洲亚洲色一区二区色99| 秋霞鲁丝片av无码| 污污网站18禁在线永久免费观看| 欧美日韩一区二区三区在线观看视频 | 少妇被粗大的猛烈进出图片| 欧洲无码精品a码无人区| 在线播放国产麻豆va剧情| 男女啪啪进出阳道猛进| 99精品视频九九精品视频| 日本簧片在线观看| 人人玩人人添人人澡| 先锋影音av最新资源| 亚洲综合久久一区二区| 久久国产精品成人影院| 国产一区二区三区四区精华| 亚洲国产欧美在线人成aaaa| 午夜影视免费| 成人综合网站| av毛片无码中文字幕不卡| 亚洲色无码播放| 亚洲日韩成人av无码网站| 国产亚洲精品久久久久久小说| 国产成 人 综合 亚洲| 亚洲精品国偷拍自产在线麻豆| 久久天天躁狠狠躁夜夜avapp| 亚洲欧美日本久久综合网站点击| 国产欧美日韩亚洲精品专区| 午夜嘿嘿嘿影院| 曰韩内射六十七十老熟女影视 | 麻豆视传媒精品av| 久久精品超碰av无码| 乱女伦露脸对白在线播放| 三级久久试看3分钟| 亚洲a∨精品一区二区三区|