在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CMTM6 Antibody

CMTM6 Antibody

  • 中文名稱：
    CMTM6兔多克隆抗體
  • 貨號：
    CSB-PA281322
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA281322(CMTM6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA281322(CMTM6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA281322(CMTM6 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CMTM6
  • 別名：
    CMTM6; CKLFSF6; CKLF-like MARVEL transmembrane domain-containing protein 6; Chemokine-like factor superfamily member 6
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human CMTM6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
  • 基因功能參考文獻：
    1. CMTM6 is present at the cell surface, associates with the PD-L1 protein, reduces its ubiquitination and increases PD-L1 protein half-life; CMTM6 enhances the ability of PD-L1-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 relies on CMTM6/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway PMID: 28813410
    2. CMTM6 depletion, via the reduction of PD-L1, significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells PMID: 28813417
    3. Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized. PMID: 12782130
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chemokine-like factor family
  • 組織特異性：
    Expressed in the leukocytes, placenta and testis.
  • 數據庫鏈接：

    HGNC: 19177

    OMIM: 607889

    KEGG: hsa:54918

    STRING: 9606.ENSP00000205636

    UniGene: Hs.380627



主站蜘蛛池模板： 狠狠躁夜夜躁人人爽超碰97香蕉 | 人人妻人人爽人人添夜夜欢视频 | 亚洲人色婷婷成人网站在线观看| 精品熟女日韩中文十区| 亚欧洲精品在线视频免费观看| 无码人妻精品丰满熟妇区| 久久99久久99久久综合| 亚洲色一区二区三区四区| 免费无码不卡视频在线观看| 久久综合九色综合欧美就去吻| 亚洲精品午夜一区二区电影院 | 一本大道东京热无码一区| 国产无遮挡又黄又爽免费网站| 亚洲成av人片在www| 裸体丰满白嫩大尺度尤物| 久久国产精品无码一区二区三区| 国产欧美久久一区二区三区| 欧美人与动人物牲交免费观看| 日韩视频 中文字幕 视频一区 | 无码成人一区二区三区| 中文字幕乱码一区av久久| 成年女人看片永久免费视频| gv天堂gv无码男同在线观看 | 精品一卡2卡三卡4卡乱码精品视频| 色欲av亚洲一区无码少妇| 丰满人妻熟妇乱又伦精品软件| 欧美亚洲日韩国产综合电影| 无码人妻一区二区三区免费n鬼逝| 女人被狂躁的高潮免费视频 | 在线观看国产成人av片| 熟妇无码熟妇毛片| 中文字幕日韩人妻在线视频| 成人做爰免费视频免费看| 理论片午午伦夜理片影院| 久久精晶国产99久久6| 噜妇插内射精品| 日本护士毛茸茸xx| 怡红院成永久免费人视频新的| 亚洲色偷拍另类无码专区| 国内精品久久久久久久久齐齐| av无码av在线a∨天堂app|