在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CMTM6 Antibody

CMTM6 Antibody

  • 中文名稱：
    CMTM6兔多克隆抗體
  • 貨號：
    CSB-PA923454
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from RAW264.7 cells, using CKLF6 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CMTM6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CMTM6
  • 別名：
    CMTM6; CKLFSF6; CKLF-like MARVEL transmembrane domain-containing protein 6; Chemokine-like factor superfamily member 6
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human CKLF6.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
  • 基因功能參考文獻：
    1. CMTM6 is present at the cell surface, associates with the PD-L1 protein, reduces its ubiquitination and increases PD-L1 protein half-life; CMTM6 enhances the ability of PD-L1-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 relies on CMTM6/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway PMID: 28813410
    2. CMTM6 depletion, via the reduction of PD-L1, significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells PMID: 28813417
    3. Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized. PMID: 12782130
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chemokine-like factor family
  • 組織特異性：
    Expressed in the leukocytes, placenta and testis.
  • 數據庫鏈接：

    HGNC: 19177

    OMIM: 607889

    KEGG: hsa:54918

    STRING: 9606.ENSP00000205636

    UniGene: Hs.380627



主站蜘蛛池模板： 不卡av电影在线| 欧美另类精品xxxx人妖| а天堂中文最新一区二区三区| 国产精品户外野外| 日韩丝袜欧美人妻制服| 亚洲日韩色在线影院性色| 中日韩产精品1卡二卡三卡| 中文无码伦av中文字幕| 欧美丰满妇大ass| 国产亚洲熟妇在线视频| 在线天堂资源www| 欧美国产一区二区三区激情无套 | 国产麻豆精品久久一二三| 女学生14毛片视频片二毛| 国产99视频精品免费视看6| 色爽黄1000部免费软件下载| 国产成人a人亚洲精品无码| 日本丰满岳乱妇在线观看| 国产又黄又爽胸又大免费视频| 乱色熟女综合一区二区三区| 怡春院国产精品视频| 亚洲乱码卡一卡二卡新区仙踪木木 | 日韩成人无码一区二区三区| 久久精品成人无码观看不卡| 久久久亚洲精品av无码| 国产精品又黄又爽又色无遮挡| 内射毛片内射国产夫妻| 日韩精品真人荷官无码| 99久久精品费精品国产| 国产av一区二区三区传媒| 日韩在线永久免费播放| 激烈的性高湖波多野结衣| 国产98在线 | 免费、| 日本在线看片免费人成视频1000| 色综合天天天天综合狠狠爱| 亚洲成a人无码| 女人18片毛片60分钟| 成人一区二区免费中文字幕视频| 亚洲 欧洲 日韩 综合av| 久久99热人妻偷产国产| 国产成人av免费网址|