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  4. CLTCL1 Antibody

CLTCL1 Antibody

  • 中文名稱：
    CLTCL1兔多克隆抗體
  • 貨號：
    CSB-PA005594LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: CLTCL1 antibody at 2µg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: NIH/3T3 whole cell lysate
      Lane 3: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 188, 181 kDa
      Observed band size: 188 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005594LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA005594LA01HU at dilution of 1:100
    • Immunofluorescence staining of A549 cells with CSB-PA005594LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CLTCL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CLTCL1 antibody; CLH22 antibody; CLTCL antibody; CLTDClathrin heavy chain 2 antibody; Clathrin heavy chain on chromosome 22 antibody; CLH-22 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Clathrin heavy chain 2 protein (1423-1566AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CLTCL1 Antibody (CSB-PA005594LA01HU)，的標記方式是Non-conjugated。對于CLTCL1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA005594LB01HU CLTCL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA005594LC01HU CLTCL1 Antibody, FITC conjugated
    Biotin CSB-PA005594LD01HU CLTCL1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
  • 基因功能參考文獻：
    1. Provide biochemical evidence for separate regulation and distinct functional niches for CHC17 and CHC22 in HeLa cells. Furthermore, the greater stability of the CHC22 coat relative to the CHC17 coat may be relevant to its excessive accumulation with GLUT4 during insulin resistance. PMID: 29097553
    2. Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development. Study suggests This suggests that a reduction in CHC22 expression in sensory neural precursors may license a step in neuron precursor neurodevelopment; and that this step is mediated through control of a novel neuropeptide processing pathway. PMID: 29402896
    3. CLTCL1 is significantly upregulated in the developing human brain PMID: 26068709
    4. Depletion of clathrin heavy chain (CHC)17, but not the CHC22 clathrin isoform, by ribonucleic acid interference (RNAi) induces centrosome amplification and multipolar spindles. PMID: 22891263
    5. CHC22 was required for retrograde trafficking of certain cargo molecules from endosomes to the trans-Golgi network. PMID: 20065094
    6. Clathrin isoform CHC22 binds to sorting nexin 5 through a coiled-coil domain. PMID: 15133132
    7. role for CHC22 in formation of insulin-responsive GLUT4 compartments in muscle & adipocytes; CHC22 associated with expanded GLUT4 compartments in muscle in type 2 diabetes PMID: 19478182

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  • 亞細胞定位：
    Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Clathrin heavy chain family
  • 組織特異性：
    Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.
  • 數據庫鏈接：

    HGNC: 2093

    OMIM: 601273

    KEGG: hsa:8218

    STRING: 9606.ENSP00000445677

    UniGene: Hs.368266



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