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CHRNG Antibody

  • 中文名稱:
    CHRNG兔多克隆抗體
  • 貨號(hào):
    CSB-PA005401ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: CHRNG antibody at 5.5μg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 58, 53 kDa
      Observed band size: 58 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CHRNG Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CHRNG
  • 別名:
    Acetylcholine receptor muscle gamma subunit antibody; Acetylcholine receptor protein gamma chain precursor antibody; Acetylcholine receptor subunit gamma antibody; ACHG antibody; ACHG_HUMAN antibody; Achr 3 antibody; AChR antibody; Achr3 antibody; ACHRG antibody; ACRG antibody; Cholinergic receptor nicotinic gamma antibody; Cholinergic receptor nicotinic gamma polypeptide antibody; CHRNG antibody; MGC133376 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Acetylcholine receptor subunit gamma protein (328-517AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻(xiàn):
    1. CHRNG mutations associated with interfamilial variability of the severity of the Escobar variant of multiple pterygium syndrome PMID: 27245440
    2. Two siblings with Escobar syndrome caused by homozygous mutations of the CHRNG gene were identified. PMID: 25411939
    3. Rare cases of congenital arthrogryposis multiplex caused by novel recurrent CHRNG mutations. PMID: 25608830
    4. We did not identify a clear difference in mutation spectrum of the CHRNG gene between lethal form and non-lethal forms of multiple pterygium syndromes PMID: 22167768
    5. CHRNG mutations identified in families with Escobar syndrome show that the trait is a congenital dysmorphology caused by transient inactivation of the neuromuscular endplate. PMID: 16826520
    6. Mutations cxause lethal and nonlethal forms of multiple pterygium syndrome. PMID: 16826531
    7. constructed and characterized four AChR gamma extracellular domain variants PMID: 18502212
    8. This study suggests for the first time in humans, a possible role for genetic variation in the neuromuscular nicotinic acetylcholine receptor, particularly the gamma subunit, in systolic blood pressure regulation PMID: 18625075
    9. Detection of PAX3/7-FKHR fusion gene by one-step RT-PCR is useful in the diagnosis of rhabdomyosarcomas (RMS) and that AChR-gamma is overexpressed in Chinese RMS patients. PMID: 18988640

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  • 相關(guān)疾病:
    Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
  • 亞細(xì)胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Gamma/CHRNG sub-subfamily
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 1967

    OMIM: 100730

    KEGG: hsa:1146

    STRING: 9606.ENSP00000374145

    UniGene: Hs.248101



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