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  4. CHRNA2 Antibody

CHRNA2 Antibody

  • 中文名稱：
    CHRNA2兔多克隆抗體
  • 貨號：
    CSB-PA621886ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: HL-60 whole cell lysate(20μg), Hela whole cell lysate(20μg), Jurkat whole cell lysate(20μg), PC-3 whole cell lysate(20μg)
      All lanes: CHRNA2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 59 kDa
      Observed band size: 60 kDa
      Exposure time: 300s
    • Immunohistochemistry image of CSB-PA621886ESR1HU diluted at 1:50 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of PC-3 cell with CSB-PA621886ESR1HU at 1:25, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and and permeated by 0.2% TritonX-100 for 15 min. Then 10% normal goat serum to block non-specific protein-protein interactions . The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品描述：

    The peptide mapping within amino acids 27-264 of the recombinant human CHRNA2 is used to immunize rabbits to generate the anti-CHRNA2 antibody. The resulting antibody is a polyclonal antibody and occurs as an unconjugated IgG. It underwent antigen affinity purification. And it is only reactive with human CHRNA2 protein, a type of receptor best known for modulating nicotine dependence in brain cells. Recent findings have been shown that CHRNA2 plays a role in energy metabolism. This CHRNA2 antibody is suitable for the detection of the CHRNA2 protein in ELISA, WB, and IHC applications.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CHRNA2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CHRNA2
  • 別名：
    ACHA2_HUMAN antibody; AChR antibody; Cholinergic receptor nicotinic alpha 2 antibody; Chrna2 antibody; Neuronal acetylcholine receptor protein subunit alpha 2 antibody; Neuronal acetylcholine receptor subunit alpha-2 antibody; Nicotinic Acetylcholine Receptor alpha 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Neuronal acetylcholine receptor subunit alpha-2 protein (27-264AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻：
    1. A crystal structure of a human neuronal CHRNA2 extracellular domain in pentameric assembly has been reported. PMID: 27493220
    2. The rare variants in CHRNA2 were significantly associated with smoking status. PMID: 25450229
    3. a heterozygous single-nucleotide substitution in CHRNA2 gene (c.1126 C>T; p. Arg376Trp) in subjects with benign familial infantile seizures PMID: 25847220
    4. CHRNA2 mutations play a causative role in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). PMID: 25770198
    5. Results show that D478E variation in nAChR alpha2 subunit increases the peak current responses of both alpha2beta2- and alpha2beta4-nAChRs; but the D478N variation in nAChR alpha2 subunit only increases the peak current responses of alpha2beta2-nAChRs PMID: 24950454
    6. Level of cigarettes per day during adolescence and young adulthood is associated with CHRNB3A6, CHRNA5A3B4, and CHRNA2 PMID: 23943838
    7. Results indicate that the CHRNA2 signal peptide mutation T22I modulates the function of both alpha2beta2- and alpha2beta4-nAChR and decreases sensitivities to nicotine and acetylcholine, and quite possibly increasing susceptibility to nicotine dependence PMID: 24467848
    8. findings indicate that both CHRNA2 and CHRNA6 play a significant role in the etiology of ND in AA and EA smokers PMID: 24253422
    9. mutations of CHRNB2 and CHRNA2 genes may be rare in Chinese autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) population. PMID: 21287502
    10. How mutations in the nAChRs can cause autosomal dominant nocturnal frontal lobe epilepsy PMID: 12121305
    11. A new CHRNA2 mutation markedly increases the receptor sensitivity to acetylcholine, indicating that the nicotinic alpha 2 subunit alteration is the underlying cause. PMID: 16826524
    12. data demonstrate the rarity of the identified CHRNA2 mutations in nocturnal frontal lobe epilepsy patients, supporting the recently reported hypothesis of a restricted role for this gene in the disease PMID: 18226955
    13. The CHRNA2 rs2043063 SNP might be a risk factor for overweight/obesity in Koreans PMID: 18588430
    14. Results suggest that neither CHRNA4 nor CHRNB2 plays a major role in Japanese methamphetamine-use disorder. PMID: 18991851
    15. Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene PMID: 19383498

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  • 相關疾病：
    Epilepsy, nocturnal frontal lobe, 4 (ENFL4)
  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-2/CHRNA2 sub-subfamily
  • 數據庫鏈接：

    HGNC: 1956

    OMIM: 118502

    KEGG: hsa:1135

    STRING: 9606.ENSP00000385026

    UniGene: Hs.57718



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