在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHRNA2 Antibody

  • 中文名稱:
    CHRNA2兔多克隆抗體
  • 貨號:
    CSB-PA168970
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA168970(CHRNA2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CHRNA2
  • 別名:
    ACHA2_HUMAN antibody; AChR antibody; Cholinergic receptor nicotinic alpha 2 antibody; Chrna2 antibody; Neuronal acetylcholine receptor protein subunit alpha 2 antibody; Neuronal acetylcholine receptor subunit alpha-2 antibody; Nicotinic Acetylcholine Receptor alpha 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human CHRNA2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻:
    1. A crystal structure of a human neuronal CHRNA2 extracellular domain in pentameric assembly has been reported. PMID: 27493220
    2. The rare variants in CHRNA2 were significantly associated with smoking status. PMID: 25450229
    3. a heterozygous single-nucleotide substitution in CHRNA2 gene (c.1126 C>T; p. Arg376Trp) in subjects with benign familial infantile seizures PMID: 25847220
    4. CHRNA2 mutations play a causative role in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). PMID: 25770198
    5. Results show that D478E variation in nAChR alpha2 subunit increases the peak current responses of both alpha2beta2- and alpha2beta4-nAChRs; but the D478N variation in nAChR alpha2 subunit only increases the peak current responses of alpha2beta2-nAChRs PMID: 24950454
    6. Level of cigarettes per day during adolescence and young adulthood is associated with CHRNB3A6, CHRNA5A3B4, and CHRNA2 PMID: 23943838
    7. Results indicate that the CHRNA2 signal peptide mutation T22I modulates the function of both alpha2beta2- and alpha2beta4-nAChR and decreases sensitivities to nicotine and acetylcholine, and quite possibly increasing susceptibility to nicotine dependence PMID: 24467848
    8. findings indicate that both CHRNA2 and CHRNA6 play a significant role in the etiology of ND in AA and EA smokers PMID: 24253422
    9. mutations of CHRNB2 and CHRNA2 genes may be rare in Chinese autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) population. PMID: 21287502
    10. How mutations in the nAChRs can cause autosomal dominant nocturnal frontal lobe epilepsy PMID: 12121305
    11. A new CHRNA2 mutation markedly increases the receptor sensitivity to acetylcholine, indicating that the nicotinic alpha 2 subunit alteration is the underlying cause. PMID: 16826524
    12. data demonstrate the rarity of the identified CHRNA2 mutations in nocturnal frontal lobe epilepsy patients, supporting the recently reported hypothesis of a restricted role for this gene in the disease PMID: 18226955
    13. The CHRNA2 rs2043063 SNP might be a risk factor for overweight/obesity in Koreans PMID: 18588430
    14. Results suggest that neither CHRNA4 nor CHRNB2 plays a major role in Japanese methamphetamine-use disorder. PMID: 18991851
    15. Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene PMID: 19383498

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Epilepsy, nocturnal frontal lobe, 4 (ENFL4)
  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-2/CHRNA2 sub-subfamily
  • 數據庫鏈接:

    HGNC: 1956

    OMIM: 118502

    KEGG: hsa:1135

    STRING: 9606.ENSP00000385026

    UniGene: Hs.57718



主站蜘蛛池模板: 成人免费无码大片a毛片小说 | 国产特级毛片aaaaaa高潮流水| 蜜桃一区二区三区| 亚洲国产精品一区二区动图| 18禁男女无遮挡啪啪网站| 无码人妻久久一区二区三区app| 麻豆成人精品国产免费| 久久久亚洲欧洲日产国产成人无码 | 欧美成人精品手机在线| 欧美亚洲日韩国产网站| 国产av影片麻豆精品传媒| 美女网站免费福利视频| 黑人巨大精品欧美黑寡妇| 国产精品久久久久久无码| 欧美成 人版中文字幕| 亚洲一区二区三区高清在线看| 亚洲线精品一区二区三区影音先锋| 艳妇臀荡乳欲伦交换h在线观看| 人妻少妇av无码一区二区| 清纯唯美经典一区二区| 中文字幕亚洲一区二区三区| 欧美丰满熟妇xx猛交| 国产午夜大地久久| 久久国产精品日本波多野结衣| 中文字幕无码免费久久99| 精品少妇ay一区二区三区| 久久99青青精品免费观看| 在线黑人抽搐潮喷| 精品人妻一区二区三区浪潮在线| 亚洲a片国产av一区无码| 狠狠色狠狠色五月激情| 精品无码专区亚洲| 精品黑人一区二区三区久久| 国产午夜鲁丝无码拍拍| 亚洲乱亚洲乱妇无码麻豆| 影音先锋每日av色资源站| 无码成人aaaaa毛片| 激情偷乱人伦小说视频| 国产一区二区丝袜高跟鞋| 亚洲老妇色熟女老太| 精品无码久久久久国产动漫3d|