在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CHCHD4 Antibody

CHCHD4 Antibody

  • 中文名稱：
    CHCHD4兔多克隆抗體
  • 貨號：
    CSB-PA850802HA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA850802HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA850802HA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CHCHD4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CHCHD4
  • 別名：
    CHCHD4 antibody; MIA40Mitochondrial intermembrane space import and assembly protein 40 antibody; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mitochondrial intermembrane space import and assembly protein 40 protein (1-142AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CHCHD4 Antibody (CSB-PA850802HA01HU)，的標記方式是Non-conjugated。對于CHCHD4 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA850802HB01HU CHCHD4 Antibody, HRP conjugated ELISA
    FITC CSB-PA850802HC01HU CHCHD4 Antibody, FITC conjugated
    Biotin CSB-PA850802HD01HU CHCHD4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes. Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake.
  • 基因功能參考文獻：
    1. First group to discover the expression of the human CHCHD4 isoforms and first to call the human gene CHCHD4, and to clone and show the expression of its alternatively expressed CHCHD4 isoforms (CHCHD4.1 and CHCHD4.2). PMID: 22214851
    2. Compared to wild type control littermates, mice with a knockout of CHCHD4 exhibit reduced weight gain when fed a high-fat diet. PMID: 26178476
    3. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1) in the cytoplasm were directly observed with in-cell NMR spectroscopy. PMID: 26589182
    4. our findings suggest that MIA40 reduction contributes to the effects of AIF deficiency on OXPHOS, as it may impact on the correct assembly and maintenance of the respiratory subunits. PMID: 26158520
    5. results demonstrate an indispensable role for hMIA40 for the export of Fe-S clusters from mitochondria. PMID: 26275620
    6. Data indicate that poptosis-inducing factor (AIF) controls the mitochondrial import of mitochondrial membrane transport protein CHCHD4. PMID: 26004228
    7. In aggregate these data suggest that the Mia40/lfALR system has a broad sequence specificity and that potential substrates may be protected from adventitious oxidation by kinetic sequestration within the mitochondrial IMS. PMID: 26014136
    8. Import and oxidative folding of proteins are kinetically and functionally coupled and depend on the expression of Mia40, ALR, and the intracellular glutathione pool. PMID: 23676665
    9. Data indicate that decreased CHCHD4 expression prevents the mitochondrial translocation of p53 while augmenting its nuclear localization and activity. PMID: 24101517
    10. illustrate a very atypical behaviour for the Mia40 precursor compared to other substrates of the MIA pathway. By contrast, interaction with Erv1 occurs after 5 min of import and relies on a more stringent specificity PMID: 23937629
    11. mitochondrial localization of MIA40 requires sulfhydryl oxidase ALR in heterologous expression yeast system. PMID: 23186364
    12. Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. PMID: 21383138
    13. biogenesis and function of MIA40 in the mitochondrial intermembrane space is dependent on redox processes involving conserved cysteine residues PMID: 16185709
    14. After passage across the translocase of the mitochondrial outer membrane Erv1 interacts via disulfide bonds with Mia40. PMID: 17336303
    15. analysis of how mitochondrial biogenesis switches the sorting pathway of the intermembrane space receptor Mia40 PMID: 18779329
    16. Catalysis involves a flow of reducing equivalents from the reduced CxC cysteine motif of Mia40 to distal and then proximal CxxC motifs of long-form ALR to the flavin ring and, finally, to cytochrome c or molecular oxygen. PMID: 19397338

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion intermembrane space.
  • 組織特異性：
    Expressed in all tissues tested, suggesting an ubiquitous expression.
  • 數據庫鏈接：

    HGNC: 26467

    OMIM: 611077

    KEGG: hsa:131474

    STRING: 9606.ENSP00000295767

    UniGene: Hs.517815



主站蜘蛛池模板： 亚洲精品一区二区中文字幕| 无遮挡裸体免费视频尤物 | 天天爽天天摸天天碰| 日射精情感性色视频| 午夜少妇性影院私人影院在线| 一个人看的www视频免费观看| 99久久精品美女高潮喷水| 中国熟妇毛多多裸交视频| 国内精品久久久久久无码| 日本高清视频wwww色| 亚洲熟女一区二区三区| 久久久噜噜噜久噜久久| 欧美日韩人成视频在线播放| 国产精品无码一区二区三级| 亚洲熟妇色自偷自拍另类| 男女车车的车车网站w98免费| 精品午夜中文字幕熟女人妻在线| 久久精品国产网红主播| 岛国av无码免费无禁网站| 色伊人亚洲综合网站| 精品国产肉丝袜久久| 人妻av中文字幕久久| 久久国产精品成人影院| 欧美日韩亚洲tv不卡久久| 欧美肥老太牲交大战| 亚洲精品乱码久久久久久蜜桃图片| 亚洲人成在线观看网站不卡 | av第一福利网站| 99精品久久精品一区二区| 久久国产劲暴∨内射新川| 大伊香蕉在线精品视频75| 亚洲成av人片一区二区三区 | 日韩久久无码免费毛片软件| 全球成人中文在线| 亚洲国产日韩欧美综合a| 国产精品久久久久久久久电影网| 久久人人爽人人爽人人片av| 亚洲无av码在线中文字幕| 2019一級特黃色毛片免費看| 国产熟女一区二区三区四区五区| 四虎永久在线高清国产精品|