在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHCHD4 Antibody

  • 中文名稱:
    CHCHD4兔多克隆抗體
  • 貨號:
    CSB-PA005319GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CHCHD4
  • 別名:
    CHCHD4 antibody; MIA40Mitochondrial intermembrane space import and assembly protein 40 antibody; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CHCHD4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes. Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake.
  • 基因功能參考文獻:
    1. First group to discover the expression of the human CHCHD4 isoforms and first to call the human gene CHCHD4, and to clone and show the expression of its alternatively expressed CHCHD4 isoforms (CHCHD4.1 and CHCHD4.2). PMID: 22214851
    2. Compared to wild type control littermates, mice with a knockout of CHCHD4 exhibit reduced weight gain when fed a high-fat diet. PMID: 26178476
    3. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1) in the cytoplasm were directly observed with in-cell NMR spectroscopy. PMID: 26589182
    4. our findings suggest that MIA40 reduction contributes to the effects of AIF deficiency on OXPHOS, as it may impact on the correct assembly and maintenance of the respiratory subunits. PMID: 26158520
    5. results demonstrate an indispensable role for hMIA40 for the export of Fe-S clusters from mitochondria. PMID: 26275620
    6. Data indicate that poptosis-inducing factor (AIF) controls the mitochondrial import of mitochondrial membrane transport protein CHCHD4. PMID: 26004228
    7. In aggregate these data suggest that the Mia40/lfALR system has a broad sequence specificity and that potential substrates may be protected from adventitious oxidation by kinetic sequestration within the mitochondrial IMS. PMID: 26014136
    8. Import and oxidative folding of proteins are kinetically and functionally coupled and depend on the expression of Mia40, ALR, and the intracellular glutathione pool. PMID: 23676665
    9. Data indicate that decreased CHCHD4 expression prevents the mitochondrial translocation of p53 while augmenting its nuclear localization and activity. PMID: 24101517
    10. illustrate a very atypical behaviour for the Mia40 precursor compared to other substrates of the MIA pathway. By contrast, interaction with Erv1 occurs after 5 min of import and relies on a more stringent specificity PMID: 23937629
    11. mitochondrial localization of MIA40 requires sulfhydryl oxidase ALR in heterologous expression yeast system. PMID: 23186364
    12. Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. PMID: 21383138
    13. biogenesis and function of MIA40 in the mitochondrial intermembrane space is dependent on redox processes involving conserved cysteine residues PMID: 16185709
    14. After passage across the translocase of the mitochondrial outer membrane Erv1 interacts via disulfide bonds with Mia40. PMID: 17336303
    15. analysis of how mitochondrial biogenesis switches the sorting pathway of the intermembrane space receptor Mia40 PMID: 18779329
    16. Catalysis involves a flow of reducing equivalents from the reduced CxC cysteine motif of Mia40 to distal and then proximal CxxC motifs of long-form ALR to the flavin ring and, finally, to cytochrome c or molecular oxygen. PMID: 19397338

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion intermembrane space.
  • 組織特異性:
    Expressed in all tissues tested, suggesting an ubiquitous expression.
  • 數據庫鏈接:

    HGNC: 26467

    OMIM: 611077

    KEGG: hsa:131474

    STRING: 9606.ENSP00000295767

    UniGene: Hs.517815



主站蜘蛛池模板: 亚洲精品第一国产综合野草社区| 国产v片在线播放免费无遮挡| 亚洲人成网站18禁止| 国产精品二区一区二区aⅴ污介绍| 伦伦影院午夜理论片| 最近中文2019字幕第二页| 日韩国产网曝欧美第一页| 吃奶呻吟打开双腿做受视频| 国产成人av一区二区三区在线观看 | 思思久久精品一本到99热| 久久97超碰色中文字幕总站 | 婷婷色爱区综合五月激情| 免费视频爱爱太爽了网站| 国产3p露脸普通话对白| 少妇特黄a一区二区三区| 久久久精品久久久久久96| 久久99国产综合精品女同| 正在播放国产乱子伦最新视频| 牛牛视频一区二区三区| 欧美激欧美啪啪片免费看| 国产最新av在线播放不卡 | 在线不卡av片免费观看| 国产普通话对白刺激| 少妇愉情理伦片高潮日本| 五月丁香啪啪激情综合色九色| √最新版天堂资源网在线下载| 国产露脸150部国语对白| 人人澡超碰碰97碰碰碰| 亚洲精品无码久久千人斩| 日本三级欧美三级人妇视频 | 92国产精品午夜福利| 中文字幕av中文字无码亚| 欧美人与动性xxxxbbbb | 国产av巨作丝袜秘书| 日韩欧美在线综合网| 欧美破苞系列二十三| 一道精品视频一区二区三区| 麻豆国产成人av高清在线| 亚洲色成人网站www永久四虎| 免费国产乱理伦片在线观看| 欧美成人午夜免费影院手机在线看|