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  4. CGGBP1 Antibody

CGGBP1 Antibody

  • 中文名稱：
    CGGBP1兔多克隆抗體
  • 貨號：
    CSB-PA005301GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CGGBP1
  • 別名：
    20 kDa CGG binding protein antibody; 20 kDa CGG-binding protein antibody; CGBP1_HUMAN antibody; CGG binding protein 1 antibody; CGG triplet repeat binding protein 1 antibody; CGG triplet repeat-binding protein 1 antibody; CGG-binding protein 1 antibody; CGGBP 1 antibody; CGGBP antibody; Cggbp1 antibody; OTTHUMP00000213853 antibody; OTTHUMP00000213877 antibody; p20 CGG binding protein antibody; p20 CGGBP antibody; p20 CGGBP DNA binding protein antibody; p20-CGGBP DNA-binding protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CGGBP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.
  • 基因功能參考文獻(xiàn)：
    1. By studying global gene expression patterns and genome-wide DNA-binding patterns of CGGBP1, it has been shown that a possible mechanism through which it affects the expression of RNA Pol II-transcribed genes in trans depends on Alu RNA. PMID: 25483050
    2. CGGBP1 has no direct effect on FMR1 transcription and CGG repeat stability. PMID: 26306647
    3. CGGBP1 protein play an important cytoprotective role in patients with cancer. PMID: 26482656
    4. CGGBP1 is a possible bidirectional regulator of CpG methylation at Alus, and acts as a repressor of methylation at L1 retrotransposons. PMID: 25981527
    5. Our results suggest that CGGBP1 phosphorylation at S164 is a novel telomere protection signal, which can affect telomere-protective function of the shelterin complex PMID: 24196442
    6. Over-expression of miR-7 could significantly inhibit the growth of human lung cancer cells in vivo and in vitro, which might be related to the down-regulated expression of tumor growth-associated protein CGGBP1 PMID: 24491049
    7. CGGBP1 depletion by RNA interference in tumor-derived cells caused an increase in the cell population at G0/G1 phase and reduced the number of cells in the S phase. PMID: 21733196
    8. CGGBP-20 downregulates the activity of 5'-region of FMR1 gene in the presence of GCC-triplets only. PMID: 20141036
    9. CGGBP1 was mapped to chromosome 3p and a sequence of 235 nucleotides 5' upstream of CGGBP1 is essential for promoter activity. PMID: 14667814
    10. Differences in factors implicated in CGG repeat instability--CGG repeat size, XS548/FRAXAC1 haplotypes, and AGG interspersion pattern-are present in the Basque populations analyzed. PMID: 19728537

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1888

    OMIM: 603363

    KEGG: hsa:8545

    STRING: 9606.ENSP00000381428

    UniGene: Hs.444818



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