CFHR2 Antibody

說(shuō)明書(shū)

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) CFHR2 Polyclonal antibody
Uniprot No.：

P36980
基因名：

CFHR2
別名：

CFHL2 antibody; CFHR2 antibody; Complement factor H related protein 2 antibody; Complement factor H-related 2 antibody; Complement factor H-related protein 2 antibody; DDESK59 antibody; Factor H-related gene 2 antibody; FHR 2 antibody; FHR-2 antibody; FHR2 antibody; FHR2_HUMAN antibody; H factor (complement)-like 3 antibody; H factor like 3 antibody; H factor like protein 2 antibody; H factor-like 3 antibody; H factor-like protein 2 antibody; HFL3 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Complement factor H-related protein 2 protein (20-269AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，CFHR2 Antibody (CSB-PA13817A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于CFHR2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱(chēng)	應(yīng)用
HRP	CSB-PA13817B0Rb	CFHR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA13817C0Rb	CFHR2 Antibody, FITC conjugated
Biotin	CSB-PA13817D0Rb	CFHR2 Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
基因功能參考文獻(xiàn)：
1. Studies indicate an association between CFHR2-rs2986127 and acute anterior uveitis (AAU) diagnosis. PMID: 27306586
2. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR2] PMID: 27196323
3. Thus CFHR2 likely acts in concert with factor H, as CFHR2 inhibits convertases while simultaneously allowing factor H assisted degradation by factor I. PMID: 24260121
4. A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay. PMID: 24334459
亞細(xì)胞定位：

Secreted.
組織特異性：

Expressed by the liver and secreted in plasma.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 4890

OMIM: 600889

KEGG: hsa:3080

STRING: 9606.ENSP00000356385

UniGene: Hs.632450

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