在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CERK Antibody

  • 中文名稱:
    CERK兔多克隆抗體
  • 貨號:
    CSB-PA005256LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate(30μg), LO2 whole cell lysate(30μg), SY5Y whole cell lysate(30μg), Hela whole cell lysate(30μg), Mouse Liver tissue lysate(30μg)
      All lanes: CERK antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 60,38 kDa
      Observed band size: 60 kDa
      Exposure time: 120s
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CERK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CERK
  • 別名:
    Acylsphingosine kinase antibody; Ceramide kinase antibody; Cerk antibody; CERK1_HUMAN antibody; dA59H18.2 antibody; dA59H18.3 antibody; hCERK antibody; KIAA1646 antibody; Lipid kinase 4 antibody; Lipid kinase LK4 antibody; LK4 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Synthesized peptide derived from human CERK
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides. Binds phosphoinositides.
  • 基因功能參考文獻(xiàn):
    1. our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway. PMID: 25164007
    2. Data suggest that inhibition of ceramide kinase (CerK) [by specific gene silencing or pharmacological inhibition] drastically reduced cell proliferation in a neuroblastoma cell line. PMID: 22579669
    3. TNF-alpha exposure of human SH-SY5Y neuroblastoma caused a profound increase in CERK activity. PMID: 22230689
    4. Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2+) ionophore-stimulated cells. PMID: 21621503
    5. We have identified a differential role for ceramide kinase in mast-cell activation PMID: 21255156
    6. Molecular cloning and functional characterization PMID: 11956206
    7. ceramide kinase and its product, C-1-P, have roles in arachidonic acid release and production of eicosanoids PMID: 12855693
    8. CERK translocates during activation from the cytosol to a lipid raft fraction PMID: 15899891
    9. Pleckstrin homology domain of CERK is not only indispensable for its activity but also act as a regulator of CERK activity. PMID: 16081073
    10. sphingoid chain was also required for substrate recognition by CERK PMID: 16170208
    11. Recombinant CERK was analyzed with regard to dependence on divalent cations, to substrate delivery, specificity, and stereoselectivity. CERK associated with the plasma membrane in CHO cells, which is mediated by the N-terminal putative pleckstrin domain. PMID: 16269826
    12. CERK-pleckstrin homology domain plays a crucial role in plasma membrane targeting through its binding to phosphatidylinositol 4,5-bisphosphate and subsequent induction of ceramide-1-phosphate production in the vicinity of the membrane. PMID: 16488390
    13. These results suggest that ceramide kinase determines the balance between pro-apoptotic ceramide and anti-apoptotic C1P to regulate cell fate, reminiscent of its function in plants. PMID: 17274985
    14. Results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT. PMID: 17392267
    15. HL-60 cells are useful for studying CerK functions in leukocyte differentiation, and they also suggest that CerK might have an important role in such differentiation. PMID: 17957442
    16. higher Ca2+ signal observed in hCERK transfected cells as well as the fact that CERK colocalized with EIgG during phagocytosis support hypothesis that Ca2+ signaling is an important factor for increasing phagocytosis and is regulated by CERK PMID: 18156590
    17. identification of a cluster of cysteines, C(347)XXXC(351)XXC(354), essential for CerK function PMID: 18662741
    18. ceramide kinase, was associated with poor pathohistological grading in breast cancer PMID: 19125296
    19. The Pleckstrin Homology (PH) domain of CERK, which is required for Golgi complex localization, can substitute for the N-terminal region of CERKL and allow for wild-type CERKL localization, which is typified by nucleolar accumulation. PMID: 19501188
    20. JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2 PMID: 19778898

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 組織特異性:
    High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 19256

    OMIM: 610307

    KEGG: hsa:64781

    STRING: 9606.ENSP00000216264

    UniGene: Hs.200668



主站蜘蛛池模板: 久久香综合精品久久伊人| 亚洲va国产va天堂va久久| 业余 自由 性别 成熟视频 视频| 国产高潮抽搐喷水高清| 欧美日韩亚洲国产综合乱| 香蕉久久人人爽人人爽人人片av| 国产成a人亚洲精品无码久久网| 少妇一夜三次一区二区| 成人无遮羞视频在线观看| 国产乱人伦偷精品视频aaa| 国产乱码二卡3卡四卡| 中文字幕人妻中文av不卡专区| 性无码免费一区二区三区在线| 国产无遮挡乱子伦免费精品| 又黄又爽的60分钟视频| 亚洲aⅴ天堂av天堂无码麻豆| 久久久免费精品re6| 国产精品内射视频免费| 久久99精品国产免费观观| 无码h肉动漫在线观看| 人妻在客厅被c的呻吟| 在线观看高h无码黄动漫| 一本一本久久a久久精品综合麻豆| 50路60路老熟妇啪啪| 丁香五月亚洲综合深深爱| 亚洲中文字幕国产综合| 77777_亚洲午夜久久多人| 51久久成人国产精品麻豆| 日日摸日日碰夜夜爽免费| 久久精品第九区免费观看| 国产美女极度色诱视频www| 欧美高清精品一区二区| 亚洲一区在线日韩在线尤物| 精品少妇爆乳无码av无码专区| 久久久久噜噜噜亚洲熟女综合| 麻豆果冻精东九一传媒mv| 欧美在线精彩视频免费播放| 久久国语露脸国产精品电影| 亚洲和欧洲一码二码区别7777| 风韵丰满熟妇啪啪区老老熟女百度| 欧美老熟妇乱子伦视频|