在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CERK Antibody

  • 中文名稱:
    CERK兔多克隆抗體
  • 貨號:
    CSB-PA549396
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA549396(CERK Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA549396(CERK Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CERK
  • 別名:
    Acylsphingosine kinase antibody; Ceramide kinase antibody; Cerk antibody; CERK1_HUMAN antibody; dA59H18.2 antibody; dA59H18.3 antibody; hCERK antibody; KIAA1646 antibody; Lipid kinase 4 antibody; Lipid kinase LK4 antibody; LK4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human CERK
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides. Binds phosphoinositides.
  • 基因功能參考文獻:
    1. our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway. PMID: 25164007
    2. Data suggest that inhibition of ceramide kinase (CerK) [by specific gene silencing or pharmacological inhibition] drastically reduced cell proliferation in a neuroblastoma cell line. PMID: 22579669
    3. TNF-alpha exposure of human SH-SY5Y neuroblastoma caused a profound increase in CERK activity. PMID: 22230689
    4. Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2+) ionophore-stimulated cells. PMID: 21621503
    5. We have identified a differential role for ceramide kinase in mast-cell activation PMID: 21255156
    6. Molecular cloning and functional characterization PMID: 11956206
    7. ceramide kinase and its product, C-1-P, have roles in arachidonic acid release and production of eicosanoids PMID: 12855693
    8. CERK translocates during activation from the cytosol to a lipid raft fraction PMID: 15899891
    9. Pleckstrin homology domain of CERK is not only indispensable for its activity but also act as a regulator of CERK activity. PMID: 16081073
    10. sphingoid chain was also required for substrate recognition by CERK PMID: 16170208
    11. Recombinant CERK was analyzed with regard to dependence on divalent cations, to substrate delivery, specificity, and stereoselectivity. CERK associated with the plasma membrane in CHO cells, which is mediated by the N-terminal putative pleckstrin domain. PMID: 16269826
    12. CERK-pleckstrin homology domain plays a crucial role in plasma membrane targeting through its binding to phosphatidylinositol 4,5-bisphosphate and subsequent induction of ceramide-1-phosphate production in the vicinity of the membrane. PMID: 16488390
    13. These results suggest that ceramide kinase determines the balance between pro-apoptotic ceramide and anti-apoptotic C1P to regulate cell fate, reminiscent of its function in plants. PMID: 17274985
    14. Results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT. PMID: 17392267
    15. HL-60 cells are useful for studying CerK functions in leukocyte differentiation, and they also suggest that CerK might have an important role in such differentiation. PMID: 17957442
    16. higher Ca2+ signal observed in hCERK transfected cells as well as the fact that CERK colocalized with EIgG during phagocytosis support hypothesis that Ca2+ signaling is an important factor for increasing phagocytosis and is regulated by CERK PMID: 18156590
    17. identification of a cluster of cysteines, C(347)XXXC(351)XXC(354), essential for CerK function PMID: 18662741
    18. ceramide kinase, was associated with poor pathohistological grading in breast cancer PMID: 19125296
    19. The Pleckstrin Homology (PH) domain of CERK, which is required for Golgi complex localization, can substitute for the N-terminal region of CERKL and allow for wild-type CERKL localization, which is typified by nucleolar accumulation. PMID: 19501188
    20. JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2 PMID: 19778898

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 組織特異性:
    High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
  • 數據庫鏈接:

    HGNC: 19256

    OMIM: 610307

    KEGG: hsa:64781

    STRING: 9606.ENSP00000216264

    UniGene: Hs.200668



主站蜘蛛池模板: 国产日产欧产美韩系列影片| 四虎影视成人永久免费观看视频| 久久久婷婷五月亚洲97号色| 亚洲精品无码av人在线观看| 国产精品国产三级国产剧情| 性色av一二三天美传媒| 99re在线播放| 少妇太爽了在线观看免费视频| 人禽无码视频在线观看| 亚洲 综合 欧美 动漫 丝袜| av网站的免费观看| 俄罗斯老熟妇色xxxx| 久久超乳爆乳中文字幕| 欧美一区二区三区视频在线观看| 亚洲人成无码网站18禁10| 东北妇女xx做爰视频| 国产成人精品日本亚洲第一区| 人妻丰满熟妇av无码区不卡| 国产欧美日韩视频怡春院| 亚洲人成黄网站69影院| 真人无码作爱免费视频| 精品少妇ay一区二区三区| 免费女人裸体视频无遮挡免费网站| 久久亚洲精品无码gv| 日本一本一区二区免费播放| 国产99在线 | 欧美| 解开人妻的裙子猛烈进入 | 久久天天躁狠狠躁夜夜网站| 色欲精品国产一区二区三区av| 波多老师无码av中字专区| 国产性生交xxxxx无码| 欧美老人巨大xxxx做受视频| 四虎永久在线精品视频免费观看| 成人无码一区二区三区网站| 国产精品毛片久久久久久久| 特级做a爰片毛片免费看108| 国产成人mv视频在线观看| 天堂亚洲国产中文在线| 日日噜噜噜噜夜夜爽亚洲精品| 中文在线中文资源| 国产做爰又粗又大又爽动漫|