在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CENPJ Antibody

  • 中文名稱:
    CENPJ兔多克隆抗體
  • 貨號:
    CSB-PA005213LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: CENPJ antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 154, 125 kDa
      Observed band size: 125 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA005213LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CENPJ Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CENPJ
  • 別名:
    BM032 antibody; CENP-J antibody; CENPJ antibody; CENPJ_HUMAN antibody; Centromere protein J antibody; Centrosomal P4.1-associated protein antibody; CPAP antibody; LAG-3-associated protein antibody; LAP antibody; LIP1 antibody; LYST interacting protein LIP1 antibody; LYST interacting protein LIP7 antibody; LYST-interacting protein 1 antibody; MCPH6 antibody; Sas 4 antibody; SASS4 antibody; SCKL4 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Centromere protein J protein (1082-1248AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,CENPJ Antibody (CSB-PA005213LA01HU),的標(biāo)記方式是Non-conjugated。對于CENPJ Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA005213LB01HU CENPJ Antibody, HRP conjugated ELISA
    FITC CSB-PA005213LC01HU CENPJ Antibody, FITC conjugated
    Biotin CSB-PA005213LD01HU CENPJ Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release.
  • 基因功能參考文獻:
    1. CPAP regulates delivery of its bound beta-tubulin to define the size of microtubule-based cellular structures using a "clutch-like" mechanism. PMID: 27306797
    2. Data suggest that alcohol/ethanol exposure diminishes pool of proliferative neurons (Neuro2a cell line) through disordering of spindle orientation and promotion of asymmetric cell division; these neuronal abnormalities appear to be due to reduced CENPJ protein expression level. PMID: 29778912
    3. CPAP-S467D protein has a low affinity for microtubule binding but a high affinity for pericentriolar material proteins. PMID: 26997271
    4. CPAP promotes timely cilium disassembly to maintain neural progenitor pool. CPAP mutation causes Seckel syndrome with microcephaly. PMID: 26929011
    5. Data suggest that the single G-box domain (that appears to fold into 14-20 antiparallel beta-strands) of CENPJ has stable but dynamic structure; CRAP forms multimers (in solution and in crystals) of elongated fibrils similar to amyloid fibrils. [REVIEW] PMID: 26517891
    6. Centrobin plays a role in the stability and centriole elongation function of CPAP and limits the centriole length. PMID: 25616662
    7. studies provide the first structural insight into how the malfunction of centriole proteins results in human disease and also reveal that the CPAP-STIL interaction constitutes a conserved key step in centriole biogenesis PMID: 24052813
    8. The results showed a human-specific hypomethylation in the 5' UTR of CENPJ in the brain, where methylation levels among humans are only about one-third of those found among nonhuman primates. PMID: 24288161
    9. Centrobin-CPAP interaction is critical for the recruitment of CPAP to procentrioles to promote the elongation of daughter centrioles and for the persistence of CPAP on preexisting mother centrioles. PMID: 24700465
    10. CPAP depletion results in asymmetric spindle poles with uneven distribution of pericentriolar material. PMID: 24491538
    11. Sas-4 acts as a vehicle to tether PCM complexes to centrioles independent of its well-known role in centriole duplication PMID: 24385583
    12. CEP120 associates with SPICE1 and CPAP, and depletion of any of these proteins results in short procentrioles. Furthermore, CEP120 or CPAP overexpression results in excessive centriole elongation, a process dependent on CEP120, SPICE1, and CPAP. PMID: 23810536
    13. SUMOylated CPAP could synergistically increase the HBx-induced NF-kappaB activity PMID: 23369793
    14. CEP120 is a CPAP-interacting protein that positively regulates centriole elongation. PMID: 23857771
    15. Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. PMID: 23511974
    16. CPAP degradation and function is controlled by the poly(ADP-ribose) polymerase tankyrase 1. PMID: 22699936
    17. STIL and CPAP are essential for centriole formation and for proper spindle position. PMID: 22100914
    18. Results suggest that Cep152 recruits Plk4 and CPAP to the centrosome to ensure a faithful centrosome duplication process. PMID: 21059844
    19. Data establishes that mutation of CENPJ can lead to Seckel syndrome and calls for further investigation of the role played by other microcephaly related genes in the pathogenesis of PD. PMID: 20522431
    20. Results identify centrosomal P4.1-associated protein (CPAP), a human homologue of SAS-4, as a substrate of PLK2 whose activity oscillates during the cell cycle. PMID: 20531387
    21. cell cycle-regulated phosphorylation orchestrates the dynamics of CPAP molecular interaction and centrosome splitting to ensure genomic stability in cell division PMID: 19889632
    22. CPAP was found to augment Stat5-mediated transcription PMID: 12198240
    23. CPAP carries a novel microtubule-destabilizing motif that not only inhibits microtubule nucleation from the centrosome but also depolymerizes taxol-stabilized microtubules. PMID: 15047868
    24. CPAP functions as a coactivator of NF-kappaB-mediated transcription PMID: 15687488
    25. Mutations in CENPJ gene is associated with autosomal recessive primary microcephaly PMID: 15793586
    26. Together, our results reveal a structural role for CPAP to maintain centrosome integrity and normal spindle morphology during cell division. PMID: 16316625
    27. In summary, our results show a direct interaction between CPAP and 14-3-3, and this interaction appears to be phosphorylation and cell cycle dependent. PMID: 16516142
    28. discuss CENPJ, which similarly exhibits higher rate of protein evolution in primates as compared to rodents and carnivores PMID: 16631324
    29. High levels of LIP1 were found in serum and synovial fluid of rheumatoid arthritis patients, providing evidence for a cytokine-like role. PMID: 18162190
    30. Mutations in this conserved sequence also eliminate d-SAS-4's microtubule-destabilizing activity, suggesting that d-SAS-4 and CPAP may play similar roles within cells. PMID: 18586240
    31. the PN2-3 fragment of CPAP as a protein with an unprecedented tubulin sequestering mechanism distinct from that of stathmin family proteins. PMID: 19131341
    32. Results suggest that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles. PMID: 19481458
    33. Data show that the CPAP is required for centrosome duplication in cycling human cells, and that CPAP overexpression results in the formation of abnormally long centrioles. PMID: 19481460
    34. Results suggest that CPAP is a new regulator of centriole length and its intrinsic tubulin-dimer binding activity is required for procentriole elongation. PMID: 19503075
    35. Identifies CENPJ as LYST-interacting proteins LIP1 and LIP7, which interact with the lysosomal trafficking regulator (LYST) protein. PMID: 11984006

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Microcephaly 6, primary, autosomal recessive (MCPH6); Seckel syndrome 4 (SCKL4)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 蛋白家族:
    TCP10 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17272

    OMIM: 608393

    KEGG: hsa:55835

    STRING: 9606.ENSP00000371308

    UniGene: Hs.513379



主站蜘蛛池模板: 亚洲一区二区三区av无码| 婷婷色婷婷开心五月四房播播| 欧美性受xxxx狂喷水| аⅴ天堂中文在线网| 久久se精品一区精品二区| av天堂中av世界中文在线播放| 亚洲熟妇丰满xxxxx| 亚洲国产精品第一区二区| 天堂а√在线中文在线新版| 麻豆传煤入口免费进入2023| 精品999日本久久久影院| 国内揄拍国内精品少妇| 无码人妻精品一区二区在线视频| 国产精品进线69影院| 一本大道东京热无码视频| 国产精品久久久久久影视不卡| 国产成人精品123区免费视频| 久久人人爽人人爽人人片av| 中文日产乱幕九区无线码| 天天躁夜夜躁狠狠综合| 日韩av无码精品一二三区| 在厨房被c到高潮a毛片奶水| 国产av精品毛片一区二区三区| 久久久久国色av∨免费看| 久久人人爽人人爽人人片av高清 | 午夜国人精品av免费看| 熟妇无码熟妇毛片| 最新国产在线拍揄自揄视频| 国精产品一品二品国精品69xx| 97成人碰碰久久人人超级碰oo| 综合 欧美 小说 另类 图| 国产精品久久久久久久久久久免费看 | 少妇的肉体k8经典| 亚洲婷婷五月激情综合app| 免免费国产aaaaa片| 老熟女重囗味hdxx69| 久久视频这里只精品| 人妻熟妇乱又伦精品视频无广告 | 久久精品一区二区三区av| 国产voyeur精品偷窥222| 污污网站18禁在线永久免费观看|