在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CDC27 Antibody

CDC27 Antibody

  • 中文名稱：
    CDC27兔多克隆抗體
  • 貨號：
    CSB-PA585818
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA585818(CDC27 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HepG2 cells, K562 cells, Primary antibody: CSB-PA585818(CDC27 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ANAPC3 antibody; Anaphase Promoting Complex 3 antibody; Anaphase promoting complex protein 3 antibody; Anaphase Promoting Complex Subunit 3 antibody; Anaphase-promoting complex subunit 3 antibody; APC 3 antibody; APC3 antibody; Cdc 27 antibody; Cdc27 antibody; CDC27 homolog antibody; CDC27_HUMAN antibody; CDC27Hs antibody; Cell Division Cycle 27 antibody; Cell division cycle protein 27 homolog antibody; D0S1430E antibody; D17S978E antibody; H NUC antibody; H-NUC antibody; HNUC antibody; Nuc2 homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CDC27
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能參考文獻：
    1. CDC27 facilitated cells invasion and metastasis via Twist pathway, leading to initiation of epithelial-mesenchymal transition and silencing of Twist expression could reverse this process. PMID: 30308498
    2. mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27 expression. PMID: 27974673
    3. The levels of CDC20 and CylinB1 increased and the levels of Ku70 and APC3 decreased after irradiation. APC/C(Cdh1) is involved in regulation of radiosensitivity in human NPC CNE-1 cells. PMID: 28004426
    4. Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system. PMID: 28257844
    5. Cdc27 is a novel binding partner of Elmo1.Cdc27-Elmo1 has a cellular role independent from the Elmo-Dock1-Rac signal module. PMID: 26882976
    6. miR-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR-27a and its downregulation conferred increased radioresistance of the cells. PMID: 25943633
    7. These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations PMID: 25680405
    8. The structures show how one APC16 binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 recruits APC7 to APC3. PMID: 25490258
    9. Low cdc27 and high securin expression predict short survival for breast cancer patients. PMID: 23755904
    10. Down-regulation of CDC27 protein is associated with radiation resistance. PMID: 23923534
    11. Data indicate that additional density present in the anaphase-promoting complex (APC/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7, a subunit specific to vertebrate APC/C. PMID: 23078409
    12. the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1-APC/C. PMID: 22139841
    13. phosphorylation of Cdc27 by CKII is involved in TGF-beta-induced activation of APC. PMID: 21209074
    14. the spindle checkpoint may regulate CDC27/APC activity at mitosis PMID: 12429948
    15. HOXC10 co-immunoprecipitates the APC subunit CDC27, and its in vitro degradation is reduced in APC-depleted extracts or by competition with the APC substrate cyclin A. PMID: 12853486
    16. The interaction is direct and is mediated by the tandem BRCA1 C-terminal domains of MDC1 and the C terminus of the Cdc27 (APC3) subunit of the anaphase-promoting complex/cyclosome. PMID: 17827148

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    APC3/CDC27 family
  • 數據庫鏈接：

    HGNC: 1728

    OMIM: 116946

    KEGG: hsa:996

    STRING: 9606.ENSP00000434614

    UniGene: Hs.463295



主站蜘蛛池模板： 亚洲 欧美 国产 动漫 综合| 日本久久综合久久综合| 成人午夜免费无码区| 亚洲人成77777在线播放网站不卡 国产 | 欧洲野花视频天堂视频p 亚洲aⅴ天堂av天堂无码 | 狠狠色丁香久久婷婷综合蜜芽五月| 中文字字幕人妻中文| 在线看片免费人成视频久网| 亚洲精品色无码av试看| 国产男女免费完整视频在线| 中文字幕亚洲综合久久菠萝蜜| 国精产品一区一区三区有限公司杨| 天堂资源中文最新版在线一区| 婷婷五月综合国产激情| 激情内射亚洲一区二区三区| 亚洲日本一区二区一本一道| 永久免费无码成人网站| 色94色欧美sute亚洲线路一| 内射老阿姨1区2区3区4区| 日日干夜夜干| 天堂官网在线资源网| 人妻三级日本三级日本三级极| 激情人妻另类人妻伦| 韩国三级中文字幕hd久久精品| 亚洲精品久久yy5099| 国产福利免费视频不卡| 无套内射在线无码播放| 一本之道高清乱码久久久| 久久久久久久久久久免费精品| 青青草原综合久久大伊人精品| 久久综合久久美利坚合众国| 蜜臀av色欲a片无人一区| 欧美乱码卡一卡二卡三新区| 亚洲国产成人乱码| 久久精品人妻无码一区二区三区v 国产薄丝脚交视频在线观看 | 3d动漫精品啪啪一区二区中 | 国产偷窥盗摄一区二区| 欧美黑人又粗又大的性格特点| 亚洲熟妇国产熟妇肥婆| 制服 丝袜 亚洲 中文 综合 | 99999久久久久久亚洲| 国产精品久久久久久久久久妞妞|