在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CDC27 Antibody

CDC27 Antibody

  • 中文名稱：
    CDC27兔多克隆抗體
  • 貨號：
    CSB-PA585818
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA585818(CDC27 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HepG2 cells, K562 cells, Primary antibody: CSB-PA585818(CDC27 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ANAPC3 antibody; Anaphase Promoting Complex 3 antibody; Anaphase promoting complex protein 3 antibody; Anaphase Promoting Complex Subunit 3 antibody; Anaphase-promoting complex subunit 3 antibody; APC 3 antibody; APC3 antibody; Cdc 27 antibody; Cdc27 antibody; CDC27 homolog antibody; CDC27_HUMAN antibody; CDC27Hs antibody; Cell Division Cycle 27 antibody; Cell division cycle protein 27 homolog antibody; D0S1430E antibody; D17S978E antibody; H NUC antibody; H-NUC antibody; HNUC antibody; Nuc2 homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CDC27
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能參考文獻：
    1. CDC27 facilitated cells invasion and metastasis via Twist pathway, leading to initiation of epithelial-mesenchymal transition and silencing of Twist expression could reverse this process. PMID: 30308498
    2. mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27 expression. PMID: 27974673
    3. The levels of CDC20 and CylinB1 increased and the levels of Ku70 and APC3 decreased after irradiation. APC/C(Cdh1) is involved in regulation of radiosensitivity in human NPC CNE-1 cells. PMID: 28004426
    4. Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system. PMID: 28257844
    5. Cdc27 is a novel binding partner of Elmo1.Cdc27-Elmo1 has a cellular role independent from the Elmo-Dock1-Rac signal module. PMID: 26882976
    6. miR-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR-27a and its downregulation conferred increased radioresistance of the cells. PMID: 25943633
    7. These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations PMID: 25680405
    8. The structures show how one APC16 binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 recruits APC7 to APC3. PMID: 25490258
    9. Low cdc27 and high securin expression predict short survival for breast cancer patients. PMID: 23755904
    10. Down-regulation of CDC27 protein is associated with radiation resistance. PMID: 23923534
    11. Data indicate that additional density present in the anaphase-promoting complex (APC/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7, a subunit specific to vertebrate APC/C. PMID: 23078409
    12. the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1-APC/C. PMID: 22139841
    13. phosphorylation of Cdc27 by CKII is involved in TGF-beta-induced activation of APC. PMID: 21209074
    14. the spindle checkpoint may regulate CDC27/APC activity at mitosis PMID: 12429948
    15. HOXC10 co-immunoprecipitates the APC subunit CDC27, and its in vitro degradation is reduced in APC-depleted extracts or by competition with the APC substrate cyclin A. PMID: 12853486
    16. The interaction is direct and is mediated by the tandem BRCA1 C-terminal domains of MDC1 and the C terminus of the Cdc27 (APC3) subunit of the anaphase-promoting complex/cyclosome. PMID: 17827148

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    APC3/CDC27 family
  • 數據庫鏈接：

    HGNC: 1728

    OMIM: 116946

    KEGG: hsa:996

    STRING: 9606.ENSP00000434614

    UniGene: Hs.463295



主站蜘蛛池模板： 最新国产成人无码久久| 蜜臀av99无码精品国产专区| 天天摸天天摸天天天天看| 国产精品人妻熟女男人的天堂| 天天鲁在视频在线观看| av 日韩 人妻 黑人 综合 无码| www夜插内射视频网站| 久久国产精久久精产国| 国产成人免费97在线观看| 无码h黄动漫在线播放网站| 亚洲综合一区国产精品| 成人午夜亚洲精品无码区| 青青草大香焦在线综合视频 | 国产精品白浆一区二小说| 97久久久人妻一区精品| 久久大蕉香蕉免费| 再深点灬舒服灬太大了在线视频| av鲁丝一区鲁丝二区鲁丝三区| 国产又色又爽又黄刺激在线视频| 精品亚洲国产成av人片传媒| 亚洲中文字幕伊人久久无码| 日韩亚洲国产激情一区浪潮av| 中文字幕人成乱码在线观看| 狠狠爱亚洲五月婷婷av| 免费国产午夜视频在线观看| 国产av午夜精品一区二区三区| 国产欧美日韩综合精品二区| 无码内射中文字幕岛国片 | 尤物av无码色av无码| 中文午夜乱理片无码| 夜夜添无码试看一区二区三区| 婷婷伊人五月尤物| 亚州av综合色区无码一区 | 青青草无码免费一二三区| 亚洲乱码一卡二卡卡3卡4卡 | 亚洲另类激情综合偷自拍图| 亚洲精品成人无限看| 学生精品国产在线视频| 上海少妇高潮狂叫喷水了| 日韩av影院在线观看| 欧美人牲口杂交在线播放免费|