在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDC27 Antibody

  • 中文名稱:
    CDC27兔多克隆抗體
  • 貨號:
    CSB-PA004999LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescent analysis of Hela cells using CSB-PA004999LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CDC27 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ANAPC3 antibody; Anaphase Promoting Complex 3 antibody; Anaphase promoting complex protein 3 antibody; Anaphase Promoting Complex Subunit 3 antibody; Anaphase-promoting complex subunit 3 antibody; APC 3 antibody; APC3 antibody; Cdc 27 antibody; Cdc27 antibody; CDC27 homolog antibody; CDC27_HUMAN antibody; CDC27Hs antibody; Cell Division Cycle 27 antibody; Cell division cycle protein 27 homolog antibody; D0S1430E antibody; D17S978E antibody; H NUC antibody; H-NUC antibody; HNUC antibody; Nuc2 homolog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cell division cycle protein 27 homolog protein (258-431AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CDC27 Antibody (CSB-PA004999LA01HU),的標記方式是Non-conjugated。對于CDC27 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA004999LB01HU CDC27 Antibody, HRP conjugated ELISA
    FITC CSB-PA004999LC01HU CDC27 Antibody, FITC conjugated
    Biotin CSB-PA004999LD01HU CDC27 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能參考文獻:
    1. CDC27 facilitated cells invasion and metastasis via Twist pathway, leading to initiation of epithelial-mesenchymal transition and silencing of Twist expression could reverse this process. PMID: 30308498
    2. mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27 expression. PMID: 27974673
    3. The levels of CDC20 and CylinB1 increased and the levels of Ku70 and APC3 decreased after irradiation. APC/C(Cdh1) is involved in regulation of radiosensitivity in human NPC CNE-1 cells. PMID: 28004426
    4. Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system. PMID: 28257844
    5. Cdc27 is a novel binding partner of Elmo1.Cdc27-Elmo1 has a cellular role independent from the Elmo-Dock1-Rac signal module. PMID: 26882976
    6. miR-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR-27a and its downregulation conferred increased radioresistance of the cells. PMID: 25943633
    7. These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations PMID: 25680405
    8. The structures show how one APC16 binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 recruits APC7 to APC3. PMID: 25490258
    9. Low cdc27 and high securin expression predict short survival for breast cancer patients. PMID: 23755904
    10. Down-regulation of CDC27 protein is associated with radiation resistance. PMID: 23923534
    11. Data indicate that additional density present in the anaphase-promoting complex (APC/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7, a subunit specific to vertebrate APC/C. PMID: 23078409
    12. the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1-APC/C. PMID: 22139841
    13. phosphorylation of Cdc27 by CKII is involved in TGF-beta-induced activation of APC. PMID: 21209074
    14. the spindle checkpoint may regulate CDC27/APC activity at mitosis PMID: 12429948
    15. HOXC10 co-immunoprecipitates the APC subunit CDC27, and its in vitro degradation is reduced in APC-depleted extracts or by competition with the APC substrate cyclin A. PMID: 12853486
    16. The interaction is direct and is mediated by the tandem BRCA1 C-terminal domains of MDC1 and the C terminus of the Cdc27 (APC3) subunit of the anaphase-promoting complex/cyclosome. PMID: 17827148

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族:
    APC3/CDC27 family
  • 數據庫鏈接:

    HGNC: 1728

    OMIM: 116946

    KEGG: hsa:996

    STRING: 9606.ENSP00000434614

    UniGene: Hs.463295



主站蜘蛛池模板: 亚洲欧美日韩国产精品一区二区| 国产啪精品视频网站免费尤物| 老熟妇性老熟妇性色| 国产成人三级一区二区在线观看一 | 亚洲国产精品无码中文字| 国产综合色在线精品| 4hu四虎永久免费地址ww416| 久久午夜夜伦鲁鲁片免费无码影视| 潮喷大喷水系列无码视频| 亚洲精品一区二区国产精华液| 国产精品免费久久久久影院仙踪林 | 婷婷激情综合色五月久久竹菊影视 | 一本大道东京热无码视频| 久久久精品人妻一区二区三区四 | 成人无码精品一区二区三区亚洲区 | 人人澡超碰碰97碰碰碰| 免费精品国偷自产在线在线 | 扒开双腿吃奶呻吟做受视频| 98色婷婷在线| 色婷婷亚洲精品综合影院| 漂亮人妻被中出中文字幕| 久久亚洲国产精品成人av秋霞| 小说区亚洲综合第1页| 久久天天躁狠狠躁夜夜躁app| 国精品无码一区二区三区左线| 精品一区二区三区无码免费视频| 无码高潮喷吹在线观看| 久久人妻夜夜做天天爽| 欧美黑人巨大xxxxx| 香港经典a毛片免费观看hd| 天堂√在线中文最新版| 免费人成视频在线观看网站| 中文字幕无码不卡免费视频| 久久永久免费专区人妻精品| 99精品国产一区二区三区不卡| 国产在线精品二区| 无码一区二区三区av免费| 国产9 9在线 | 免费| 亚洲成a人片在线观看中文无码| 艳妇乳肉豪妇荡乳xxx| 亚洲高清成人av电影网站 |