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  4. CDC14A Antibody

CDC14A Antibody

  • 中文名稱：
    CDC14A兔多克隆抗體
  • 貨號：
    CSB-PA070087
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CDC14A antibody; Dual specificity protein phosphatase CDC14A antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody; CDC14 cell division cycle 14 homolog A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Cdc14a phosphatase.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
  • 基因功能參考文獻：
    1. Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. Authors therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy. PMID: 28465438
    2. Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness. PMID: 27259055
    3. Overexpressed miR-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR- 301a may be useful for osteosarcoma diagnosis and therapy. PMID: 27323075
    4. hCDC14A is down-regulated in many tumor tissues and reduced hCDC14A expression is correlated with poorer survival of patients with cancer PMID: 26747605
    5. These findings indicated that ZIPK may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A. PMID: 25503649
    6. hCdc14A might be involved in cell cycle regulation in cultured human brain vascular endothelial cells during high glucose-, free fatty acids-, and hypoxia-induced injury. PMID: 25463242
    7. Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes. PMID: 21233601
    8. Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis. PMID: 20956543
    9. human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. PMID: 20479464
    10. human Cdc14A phosphatase disrupts centrosome separation PMID: 11901424
    11. Data suggest that hCdc14A phosphatase plays a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. PMID: 12134069
    12. analysis of iron-responsive elements in the 3'UTR of CDC14a protein PMID: 16760464
    13. hCdc14A is differentially expressed in human cancer cells and can interact with both p53 and the Cdk1/cyclin B complex; it may play a role in carcinogenesis PMID: 16784539
    14. Cdc14A may be involved in the cell cycle regulation of Cdc25A stability. PMID: 17172867
    15. RN-tre phosphorylation is critical for efficient hCdc14A association PMID: 17371873
    16. PLK1-HsCdc14A interaction provides a temporal regulation of HsCdc14A in chromosome segregation during mitosis. PMID: 17623655
    17. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225

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  • 相關疾病：
    Deafness, autosomal recessive, 105 (DFNB105)
  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Cell projection, kinocilium. Cell projection, stereocilium.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
  • 數據庫鏈接：

    HGNC: 1718

    OMIM: 603504

    KEGG: hsa:8556

    STRING: 9606.ENSP00000354916

    UniGene: Hs.127411



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